Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
-
Muhammad S. Ali
,
Ghafoor Ahmed
Abstract
Structure-activity relationship studies on oleanolic acid (1) have resulted in facile syntheses of its new C-28 esters 2–7 by way of one-pot reaction of 1 with a variety of alkylating agents. Oleanolic acid and its new esters were studied for their in vitro antiproliferative effect on healthy human peripheral blood mononuclear cell isolated phytohemagglutinin activated T cells. Results showed that compounds 1, 3, and 5 exhibited significant inhibitory activity on T-cell proliferation. Compound 5 was found to be the most potent, with an IC50 value of 4.249 μg/mL, among all tested compounds, and its activity could be attributed to the presence of bromine atom in the molecule.
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Articles in the same Issue
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Articles in the same Issue
- Frontmatter
- Research Articles
- Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima
- Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
- Biodiversity and full genome sequence of potato viruses Alfalfa mosaic virus and potato leaf roll virus in Egypt
- Carotenoids, tocopherols, organic acids, charbohydrate and mineral content in different medicinal plant extracts
- Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.
- Antimicrobial activity and active compounds of a Rhus verniciflua Stokes extract
- Benzimidazole – Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor
