Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima
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Abdur Rauf
Abstract
The aim of the current work was to explore the muscle relaxant effect of pistagremic acid (PA) isolated from Pistacia integerrima in various animal paradigms. In a rotarod test, PA caused a significant (p<0.05) muscle relaxant potential in a dose-dependent manner. When studied in the inclined plane test, pretreatment with PA (5 and 10 mg/kg) caused promising activity (p<0.05) after treatment for 30, 60 and 90 min. The muscle relaxant potential of PA was strongly complimented by the traction and chimney tests, showing a dominant effect after 60 min of treatment. In conclusion, PA possesses strong muscle relaxant activity in various animal-based models.
Acknowledgments
The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for the continuous support. This work was supported financially by the Deanship of Scientific Research at Umm Al-Qura University to Dr. Saud Bawazeer (Grant Code: 15-MED-3-2-0001). The authors would also like to extend their sincere appreciation to the Deanship of Scientific Research (Group No. RG-007-2016).
Declaration of interest: The authors report no declarations of interest.
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Articles in the same Issue
- Frontmatter
- Research Articles
- Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima
- Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
- Biodiversity and full genome sequence of potato viruses Alfalfa mosaic virus and potato leaf roll virus in Egypt
- Carotenoids, tocopherols, organic acids, charbohydrate and mineral content in different medicinal plant extracts
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Articles in the same Issue
- Frontmatter
- Research Articles
- Muscle relaxant activities of pistagremic acid isolated from Pistacia integerrima
- Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
- Biodiversity and full genome sequence of potato viruses Alfalfa mosaic virus and potato leaf roll virus in Egypt
- Carotenoids, tocopherols, organic acids, charbohydrate and mineral content in different medicinal plant extracts
- Two new usnic acid derivatives from the endophytic fungus Mycosphaerella sp.
- Antimicrobial activity and active compounds of a Rhus verniciflua Stokes extract
- Benzimidazole – Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor
