Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae)
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Juliane C. Silva
Abstract
Annona vepretorum Mart. (Annonaceae) is a species popularly known in Brazil as “araticum” and “pinha da Caatinga”. We have evaluated the antinociceptive effects of A. vepretorum in formalin-, capsaicin-, and glutamate-induced orofacial nociception in mice. Male Swiss mice were pretreated with either saline (p.o.), A. vepretorum ethanol extract (Av-EtOH 25, 50 and 100 mg/kg, p.o.), or morphine (10 mg/kg, i.p.), before formalin, capsaicin, or glutamate was injected into the right upper lip. Pre-treatment with Av-EtOH at all doses produced a reduction in face-rubbing behavior induced by formalin in both phases, and these pre-treatments also produced a significant antinociceptive effect in the capsaicin and glutamate tests. Pre-treatment with naloxone (1.5 mg/kg, i.p.) did not reverse the antinociceptive activity of the extract at the dose of 100 mg/kg in the first phase of this test. Our results suggest that Av-EtOH might be useful in the treatment of orofacial pain.
Acknowledgments
This work was supported by grants from the Brazilian agencies CAPES, CNPq and FACEPE. The authors wish to express their thanks to R. Mello Silva of Centro de Referência para Recuperação de Áreas Degradadas (CRAD) for botanical identification of the plant material.
References
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- In vitro neuroprotective potential of the monoterpenes α-pinene and 1,8-cineole against H2O2-induced oxidative stress in PC12 cells
- Neem tree (Azadirachta indica) extract specifically suppresses the growth of tumors in H22-bearing Kunming mice
- Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae)
- Identification and characterization of microRNAs and their target genes from Nile tilapia (Oreochromis niloticus)
- Chemotherapeutic effect of Berberis integerrima hydroalcoholic extract on colon cancer development in the 1,2-dimethyl hydrazine rat model
- New flavonoid C–O–C dimers and other chemical constituents from Garcinia brevipedicellata stem heartwood
- GDP-D-mannose pyrophosphorylase from Pogonatherum paniceum enhances salinity and drought tolerance of transgenic tobacco
- Hypoglycemic activity of Gleditsia caspica extract and its saponin-containing fraction in streptozotocin-induced diabetic rats
- Antinociceptive activity of Tibouchina pereirae, an endemic plant from the Brazilian semiarid region
- Heteroplasmy and atrazine resistance in Chenopodium album and Senecio vulgaris
- Extremely high boron tolerance in Puccinellia distans (Jacq.) Parl. related to root boron exclusion and a well-regulated antioxidant system
Articles in the same Issue
- Frontmatter
- In vitro neuroprotective potential of the monoterpenes α-pinene and 1,8-cineole against H2O2-induced oxidative stress in PC12 cells
- Neem tree (Azadirachta indica) extract specifically suppresses the growth of tumors in H22-bearing Kunming mice
- Orofacial antinociceptive effect of the ethanolic extract of Annona vepretorum Mart. (Annonaceae)
- Identification and characterization of microRNAs and their target genes from Nile tilapia (Oreochromis niloticus)
- Chemotherapeutic effect of Berberis integerrima hydroalcoholic extract on colon cancer development in the 1,2-dimethyl hydrazine rat model
- New flavonoid C–O–C dimers and other chemical constituents from Garcinia brevipedicellata stem heartwood
- GDP-D-mannose pyrophosphorylase from Pogonatherum paniceum enhances salinity and drought tolerance of transgenic tobacco
- Hypoglycemic activity of Gleditsia caspica extract and its saponin-containing fraction in streptozotocin-induced diabetic rats
- Antinociceptive activity of Tibouchina pereirae, an endemic plant from the Brazilian semiarid region
- Heteroplasmy and atrazine resistance in Chenopodium album and Senecio vulgaris
- Extremely high boron tolerance in Puccinellia distans (Jacq.) Parl. related to root boron exclusion and a well-regulated antioxidant system
