Unguisin F, a new cyclic peptide from the endophytic fungus Mucor irregularis
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Sergi H. Akone
Abstract
The new cyclic heptapeptide unguisin F (1) and the known congener unguisin E (2), were obtained from the endophytic fungus Mucor irregularis, isolated from the medicinal plant Moringa stenopetala, collected in Cameroon. The structure of the new compound was unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configuration of the amino acid residues of 1 and 2 was determined using Marfey’s analysis. Compounds 1 and 2 were evaluated for their antibacterial and antifungal potential, but failed to display significant activities.
Acknowledgments
The financial support by the German Federal Ministry of Education and Support (BMBF; Bundesministerium für Bildung und Forschung) granted to P.P. is gratefully acknowledged. S. A. wishes to thank the German Academic Exchange Service (DAAD; Deutscher Akademischer Austauschdienst) for a doctoral scholarship. We are indebted to Prof. H. Brötz-Oesterhelt (Heinrich-Heine University, Duesseldorf, Germany) for antibacterial assays and to Mrs. Rini Muharini (Heinrich-Heine University, Duesseldorf, Germany) for antifungal tests.
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Articles in the same Issue
- Frontmatter
- Synergistic inhibitory effect of scopoletin and bisdemethoxycurcumin on Tetranychus cinnabarinus (Boisduval) (Acari: Tetranychidae)
- Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria
- Unguisin F, a new cyclic peptide from the endophytic fungus Mucor irregularis
- The protective effect of daidzein on high glucose-induced oxidative stress in human umbilical vein endothelial cells
- Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp., on human hepatic and colorectal cancer cells
- Obituary
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Articles in the same Issue
- Frontmatter
- Synergistic inhibitory effect of scopoletin and bisdemethoxycurcumin on Tetranychus cinnabarinus (Boisduval) (Acari: Tetranychidae)
- Alkaloid profiles and acetylcholinesterase inhibitory activities of Fumaria species from Bulgaria
- Unguisin F, a new cyclic peptide from the endophytic fungus Mucor irregularis
- The protective effect of daidzein on high glucose-induced oxidative stress in human umbilical vein endothelial cells
- Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp., on human hepatic and colorectal cancer cells
- Obituary
- Professor Peter Böger (23.03.1935 – 22.10.2015)
