Polyphosphoric acid (PPA): a new, highly efficient catalyst for the synthesis of functionalized azepino phthalazine hybrids
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Esma Lamera
Abstract
A new, convenient and efficient method for the construction of a new polycyclic condensed system containing an azepine and pyrazolophthalazine has been developed in the form of a two-step protocol comprising the condensation reaction of hydroxylamine with 1H-indazolo[1,2-b]phthalazine-1,6,11-trione derivative, followed by a Beckman rearrangement reaction using polyphosphoric acid (PPA) as catalyst. Various substituted substrates were successfully used, affording the azepino phthalazine hybrids in good yields and in short reaction times.
Acknowledgements
We are grateful to the Ministère de l’Enseignement Supérieur et de la Recherche Scientifique–Algérie (MESRS) for financial support.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: E. Lamera: Investigation, Methodology. A. Chibani: Investigation. Z. Bouaziz: Investigation, Formal analysis. M. Le Borgne: Investigation, Methodology, Validation. R. Maadadi: Investigation, Formal analysis. A. Bouraiou: Resources, Writing – original draft, Writing – review & editing, Visualization. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors declare no conflicts of interest regarding this article.
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Research funding: This research received no specific grant from any funding agency in the public, commercial, or not for profit sectors.
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Data availability: Not applicable.
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© 2024 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- In this issue
- Research Articles
- Polyphosphoric acid (PPA): a new, highly efficient catalyst for the synthesis of functionalized azepino phthalazine hybrids
- State-dependent gas chromatography based on flexible and tunable porous coordination polymers
- A novel samarium(III) orotate complex [NaSm(orotate)4(H2O)10]·3H2O – crystal structure and vibrational spectra
- (NH4)4[SO4][CB11H12]2: a new double salt with carbaborate anions crystallizing in a monoclinic variant of the anti-K2NiF4-type structure
- K[Hg(CN)2][H3CCOO]: a pseudo-double salt with mercury(II)-cyanide molecules imbedded into an ionic matrix of potassium acetate
- An aminosilyl-functionalized zincocene
- The stannide SrPd2.23Sn1.73 with CaBe2Ge2-type structure
- Note
- Revisiting Na[C(CN)3] – refinement of the crystal structure from X-ray powder diffraction data, the Raman and IR spectra
- Corrigendum
- Corrigendum zu: Die Serie caesiumhaltiger Thioarsenate(V) der Lanthanoide vom Formeltyp Cs3 Ln[AsS4]2 mit Ln = La–Nd und Sm
Articles in the same Issue
- Frontmatter
- In this issue
- Research Articles
- Polyphosphoric acid (PPA): a new, highly efficient catalyst for the synthesis of functionalized azepino phthalazine hybrids
- State-dependent gas chromatography based on flexible and tunable porous coordination polymers
- A novel samarium(III) orotate complex [NaSm(orotate)4(H2O)10]·3H2O – crystal structure and vibrational spectra
- (NH4)4[SO4][CB11H12]2: a new double salt with carbaborate anions crystallizing in a monoclinic variant of the anti-K2NiF4-type structure
- K[Hg(CN)2][H3CCOO]: a pseudo-double salt with mercury(II)-cyanide molecules imbedded into an ionic matrix of potassium acetate
- An aminosilyl-functionalized zincocene
- The stannide SrPd2.23Sn1.73 with CaBe2Ge2-type structure
- Note
- Revisiting Na[C(CN)3] – refinement of the crystal structure from X-ray powder diffraction data, the Raman and IR spectra
- Corrigendum
- Corrigendum zu: Die Serie caesiumhaltiger Thioarsenate(V) der Lanthanoide vom Formeltyp Cs3 Ln[AsS4]2 mit Ln = La–Nd und Sm
