Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes
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Abstract
A new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-triazolidine-3-thiones, and Knoevenagel condensation products was synthesized from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested in vitro for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans in comparison with imipenem (intravenous β-lactam antibiotic) and clotrimazole (antifungal medication) as reference drugs by using the agar diffusion technique. 3-Aryl-1-phenyl-1H-pyrazole-4-carbonitriles 8b, 8c, and 8d showed significant antifungal activity against the fungus C. albicans.
References
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Articles in the same Issue
- Frontmatter
- In this Issue
- Influence of different metal ions on the assembly, structures, and properties of two complexes based on the semi-rigid bis(pyridyl)-bis(amide) ligand and 4,4′-oxybis(benzoic acid)
- Structural, spectral and docking studies of a coordination polymer of zinc(II) formed by a pyridine-derived linker
- The isolation and structural elucidation of a new iridoid glycoside from Cymbaria dahurica L.
- Two new alkylresorcinol derivatives from the leaves of Scyphocephalium ochocoa
- Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes
- Studying the reactivity of N-2-(2-aminobenzoyl)-N-phenyl-hydrazinecarbothioamide toward some selected carbonyl compounds
- A Zn(II) complex from an imidazolyl-thiophene ligand: synthesis, structural characterization, and fluorescence
- A study on the reaction of 3-alkyl(aryl)imidazo[1,5-a]pyridines with ninhydrin
- Synthesis, structural characterization, and properties of Ag(I) complexes with N-donor ligands
Articles in the same Issue
- Frontmatter
- In this Issue
- Influence of different metal ions on the assembly, structures, and properties of two complexes based on the semi-rigid bis(pyridyl)-bis(amide) ligand and 4,4′-oxybis(benzoic acid)
- Structural, spectral and docking studies of a coordination polymer of zinc(II) formed by a pyridine-derived linker
- The isolation and structural elucidation of a new iridoid glycoside from Cymbaria dahurica L.
- Two new alkylresorcinol derivatives from the leaves of Scyphocephalium ochocoa
- Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes
- Studying the reactivity of N-2-(2-aminobenzoyl)-N-phenyl-hydrazinecarbothioamide toward some selected carbonyl compounds
- A Zn(II) complex from an imidazolyl-thiophene ligand: synthesis, structural characterization, and fluorescence
- A study on the reaction of 3-alkyl(aryl)imidazo[1,5-a]pyridines with ninhydrin
- Synthesis, structural characterization, and properties of Ag(I) complexes with N-donor ligands
