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Water soluble biguanide salts and their 1,3,5-triazine derivatives as inhibitors of acetylcholinesterase and α-glucosidase

  • Ozge Gungor , Seda Nur Kertmen Kurtar and Muhammet Kose EMAIL logo
Published/Copyright: August 31, 2020
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Zeitschrift für Kristallographie - Crystalline Materials
From the journal Zeitschrift für Kristallographie - Crystalline Materials Volume 235 Issue 10

Abstract

Seven biguanide derivatives were prepared by the nucleophilic reaction between dicyandiamide and p-substitute aniline derivatives or memantine or adamantine under acidic conditions. The cyclization of the biguanide compounds were also conducted via acetone to give 1,3,5-triazine derivatives. The structures of the synthesized compounds were characterized by analytical methods. The solid state structures of [HL5]Cl, [H2L7]Cl2, [HL1a]Cl and [HL5a]Cl were investigated by X-ray diffraction study. The acetylcholinesterase and α-glucosidase inhibitor properties of the compounds were then evaluated by the spectroscopic method. The compounds were found to show considerable acetylcholinesterase and α-glucosidase inhibitory activities compared to the approved drugs. The cyclization of biguanide derivatives with acetone did not affect inhibition of acetylcholinesterase, yet increased the α-glucosidase inhibition.

Keywords: acetylcholinesterase (AChE); biguanide; inhibitor; molecular structure; α-glucosidase; 1,3,5-triazine
Corresponding author: Muhammet Kose, Chemistry Department, Kahramanmaras Sutcu Imam University, Kahramanmaras, 46050, Turkey, Email:

Funding source: The Research Unit of Kahramanmaras Sutcu Imam University, Turkey

Award Identifier / Grant number: 2018/5-17M

Award Identifier / Grant number: 2019/6-22M

Funding source: Turkish Council of Higher Education

Award Identifier / Grant number: YOK 100/2000

Acknowledgments

We are grateful to The Research Unit of Kahramanmaras Sutcu Imam University, Turkey, for the financial support of this work (Project numbers: 2018/5-17M, 2019/6-22M). We also thank to the Turkish Council of Higher Education for the award (YOK 100/2000) of a postgraduate scholarship (to SNKK and OG).

  1. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  2. Research funding: This work was supported by The Research Unit of Kahramanmaras Sutcu Imam University, Turkey, for the financial support of this work (Project numbers: 2018/5-17M, 2019/6-22M). We also thank to the Turkish Council of Higher Education for the award (YOK 100/2000) of a postgraduate scholarship (to SNKK and OG).

  3. Conflict of interest statement: Authors state no conflict of interest.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/zkri-2020-0025).

Received: 2020-03-09
Accepted: 2020-06-19
Published Online: 2020-08-31
Published in Print: 2020-10-25

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Graphical Synopsis
  3. Miscellaneous
  4. Wolfgang Jeitschko, 27.05.1936--05.08.2020
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  6. Superstructure formation in Sc5Cu2In4
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https://doi.org/10.1515/zkri-2020-0025
Keywords for this article
acetylcholinesterase (AChE); biguanide; inhibitor; molecular structure; α-glucosidase; 1,3,5-triazine

Articles in the same Issue

  1. Frontmatter
  2. Graphical Synopsis
  3. Miscellaneous
  4. Wolfgang Jeitschko, 27.05.1936--05.08.2020
  5. Original papers
  6. Superstructure formation in Sc5Cu2In4
  7. Cd2 and Co2 dumbbell formation in the yttrium-rich intermetallic compounds Y14Ni3Cd3 and Y6Co2Zn
  8. Crystal structure of the synthetic analogue of iwateite, Na2BaMn(PO4)2: an X-ray powder diffraction and Raman study
  9. Layered calcium hydrogen selenite chlorides Ca(HSeO3)Cl and Ca(HSeO3)Cl(H2O), the first halides obtained in СaCl2–H2SeO3–H2O system
  10. Crystal structure of incommensurate ηʺ-Cu1.235Sn intermetallic
  11. Synthesis, properties and crystal structure of novel Copper(II) ammine complex with [Pd(CN)4]2− building blocks
  12. Water soluble biguanide salts and their 1,3,5-triazine derivatives as inhibitors of acetylcholinesterase and α-glucosidase
  13. Letter
  14. Attractive halogen···halogen interactions in crystal structure of trans-dibromogold(III) complex
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