Home Dynamic light scattering study on quercetin/surfactant/solvent system
Article
Licensed
Unlicensed Requires Authentication

Dynamic light scattering study on quercetin/surfactant/solvent system

  • Alişan Güzeloğlu

    Alişan Güzeloğlu did Master of Science in Chemistry at Warsaw University. He has published three articles in the reputed journals.

    , Ajaya Bhattarai

    Dr. Ajaya Bhattarai is the Head and Professor of the Department of Chemistry, Mahendra Morang Adarsh Multiple Campus, Tribhuvan University, Biratnagar, Nepal. He received his M.Sc. degree in Physical Chemistry from Tribhuvan University in 1998 and Ph.D. degree in Polymer Chemistry from North Bengal University, India in 2010. He has been working at Tribhuvan University since 2002. Prof. Bhattarai visited the University of Warsaw, Poland, for Erasmus Mundus post-doctoral research in nanomaterials as well as surface chemistry in 2013. His current research interests are in polymer chemistry, nanomaterials, surface chemistry, liquid alloys, crystallography, and theoretical chemistry. He has served as the Fulbright post-doctoral researcher for “Theoretical Studies on Glass-Forming Liquids” at Boston College in the USA in 2019. He has been featured in the “World’s Top 2 % Scientists 2023” list by Stanford University, USA.

    EMAIL logo
    and Hanna Wilczura-Wachnik

    Dr. Hanna Wilczura-Wachnik is a Polish chemist as well as researcher and faculty member of Chemistry of Warsaw University, Poland. She received her Master of Science in Chemistry, Warsaw University, 1977, Doctor of Philosophy in Chemistry, Warsaw University, 1992. She has also received Didactics award, Warsaw University, 2000, 2005, Research award, 2001, 2004. She is the member solidarity, Warsaw, since 1980; member of Polish Society Calorimetry and Thermal Analysis, Polish Chemical Society.

    EMAIL logo
Published/Copyright: August 13, 2024
Become an author with De Gruyter Brill

Abstract

The Dynamic Light Scattering (DLS) measurements have been performed on quercetin with dioctyl sodium sulfosuccinate (Aerosol OT, AOT), Triton X-100 in 1,4-dioxane, as well as on the solutions containing water in the core of suitable reversed micelles; the water amount was calculated using the relation R = [H2O]/[surfactant], defining the ratio of water to surfactant concentration. The amount of quercetin in the studied systems as well as the effects of the water presence on the size of the micelles and diffusion effects were discussed. A significant effect of the research was the determination of the maximum amount of water that can be introduced into the AOT micelles in the studied systems.


Corresponding authors: Ajaya Bhattarai, Department of Chemistry, M.M.A.M.C., Tribhuvan University, Biratnagar, Nepal; and Department of Chemistry, Indian Institute of Technology, Madras, Chennai, India, E-mail: ; and Hanna Wilczura-Wachnik, Faculty of Chemistry, University of Warsaw, Warsaw, Poland, E-mail:

About the authors

Alişan Güzeloğlu

Alişan Güzeloğlu did Master of Science in Chemistry at Warsaw University. He has published three articles in the reputed journals.

Ajaya Bhattarai

Dr. Ajaya Bhattarai is the Head and Professor of the Department of Chemistry, Mahendra Morang Adarsh Multiple Campus, Tribhuvan University, Biratnagar, Nepal. He received his M.Sc. degree in Physical Chemistry from Tribhuvan University in 1998 and Ph.D. degree in Polymer Chemistry from North Bengal University, India in 2010. He has been working at Tribhuvan University since 2002. Prof. Bhattarai visited the University of Warsaw, Poland, for Erasmus Mundus post-doctoral research in nanomaterials as well as surface chemistry in 2013. His current research interests are in polymer chemistry, nanomaterials, surface chemistry, liquid alloys, crystallography, and theoretical chemistry. He has served as the Fulbright post-doctoral researcher for “Theoretical Studies on Glass-Forming Liquids” at Boston College in the USA in 2019. He has been featured in the “World’s Top 2 % Scientists 2023” list by Stanford University, USA.

Hanna Wilczura-Wachnik

Dr. Hanna Wilczura-Wachnik is a Polish chemist as well as researcher and faculty member of Chemistry of Warsaw University, Poland. She received her Master of Science in Chemistry, Warsaw University, 1977, Doctor of Philosophy in Chemistry, Warsaw University, 1992. She has also received Didactics award, Warsaw University, 2000, 2005, Research award, 2001, 2004. She is the member solidarity, Warsaw, since 1980; member of Polish Society Calorimetry and Thermal Analysis, Polish Chemical Society.

Acknowledgements

Authors are greatly thankful to Department of Chemistry, University of Warsaw, Poland, for support and infrastructure facilities. AB acknowledges TWAS-UNESCO Associateship-Ref.3240321550 for providing opportunities to visit Department of Chemistry, Indian Institute of Technology Madras, Chennai, India.

  1. Research ethics: Not applicable.

  2. Author contributions: Alişan Güzeloğlu: Conceptualization, Data curation, Investigation, Methodology, Project administration. Ajaya Bhattarai: Formal analysis, Resources, Software, Writing-Original draft. Hanna Wilczura-Wachnik: Funding acquisition, Validation, Visualization, Writing-review & editing.

  3. Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.

  4. Research funding: None declared.

  5. Data availability: Data will be made available on request.

References

1. Lesjak, M.; Beara, I.; Simin, N.; Pintać, D.; Majkić, T.; Bekvalac, K.; Orčić, D.; Mimica-Dukić, N. Antioxidant and Anti-inflammatory Activities of Quercetin and its Derivatives. J. Funct. Foods, 2018, 40, 68–75. https://doi.org/10.1016/j.jff.2017.10.047.Search in Google Scholar

2. Kaur, C.; Kapoor, H. C. Antioxidants in Fruits and Vegetables – the Millennium’s Health. Int. J. Food Sci. Tech. 2001, 36 (7), 703–725. https://doi.org/10.1111/j.1365-2621.2001.00513.x.Search in Google Scholar

3. Shebis, Y.; Iluz, D.; Kinel-Tahan, Y.; Dubinsky, Z.; Yehoshua, Y. Natural Antioxidants: Function and Sources. Food Nutr. Sci. 2013, 4 (6), 643–649. https://doi.org/10.4236/fns.2013.46083.Search in Google Scholar

4. Chirumbolo, S. The Role of Quercetin, Flavonol and Flavones in Modulating Inflammatory Cell Function. Inflammation Allergy: Drug Targets. 2010, 9 (4), 263–285. https://doi.org/10.2174/187152810793358741.Search in Google Scholar PubMed

5. D’Andrea, G. Quercetin: A Flavonol with Multifaceted Therapeutic Applications? Fititerapia 2015, 106, 256–271. https://doi.org/10.1016/j.fitote.2015.09.018.Search in Google Scholar PubMed

6. Mocek, M.; Richardson, P. J. Kinetics and Mechanism of Quercetin Oxidation. J. Inst. Brew. 1972, 78, 459–465. https://doi.org/10.1002/j.2050-0416.1972.tb03481.x.Search in Google Scholar

7. Giada, M. L. R. Food Phenolic Compounds: Main Classes, Sources and Their Antioxidant Power. In Oxidative Stress and Chronic Degenerative Diseases; Morales-González, J. A., ed.; IntechOpen: Rijeka, Chapter 4, 2023; pp 87–112.Search in Google Scholar

8. Parasuraman, S.; Anand David, A.; Arulmoli, R. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn. Rev. 2016, 10, 84–89. https://doi.org/10.4103/0973-7847.194044.Search in Google Scholar PubMed PubMed Central

9. Burda, S.; Oleszek, W. Antioxidant and Antiradical Activities of Flavonoids. J. Agric. Food Chem 2001, 49, 2774–2779. https://doi.org/10.1021/jf001413m.Search in Google Scholar PubMed

10. Bukhari, S. B.; Memon, S.; Mahroof-Tahir, M.; Bhanger, M. I. Synthesis, Characterization and Antioxidant Activity Copper–Quercetin Complex. Spectrochim. Acta A Mol. Biomol. Spectrosc 2009, 71, 1901–1906. https://doi.org/10.1016/j.saa.2008.07.030.Search in Google Scholar PubMed

11. Ghosh, N.; Chakraborty, T.; Mallick, S.; Mana, S.; Singha, D.; Ghosh, B.; Roy, S. Synthesis, Characterization and Study of Antioxidant Activity of Quercetin–Magnesium Complex. Spectrochim. Acta A Mol. Biomol. Spectrosc 2015, 151, 807–813. https://doi.org/10.1016/j.saa.2015.07.050.Search in Google Scholar PubMed

12. Kim, M.; Park, Y.; Cho, S.; Burapan, S.; Han, J. Synthesis of Alkyl Quercetin Derivatives. J. Korean Soc. Appl. Biol. Chem. 2015, 58, 343–348. https://doi.org/10.1007/s13765-015-0050-x.Search in Google Scholar

13. Ezzati, M.; Yousefi, B.; Velaei, K.; Safa, A. A Review on Anti-cancer Properties of Quercetin in Breast Cancer. Life Sci. 2020, 248, 117463. https://doi.org/10.1016/j.lfs.2020.117463.Search in Google Scholar PubMed

14. Karimi, A.; Naeini, F.; Asghari Azar, V.; Hasanzadeh, M.; Ostadrahimi, A.; Niazkar, H. R.; Mobasseri, M.; Tutunchi, H. A Comprehensive Systematic Review of the Therapeutic Effects and Mechanisms of Action of Quercetin in Sepsis. Phytomedicine 2021, 86, 153567. https://doi.org/10.1016/j.phymed.2021.153567.Search in Google Scholar PubMed

15. Deepika; Maurya, P. K. Health Benefits of Quercetin in Age-Related Diseases. Molecules 2022, 27, 2498–2512. https://doi.org/10.3390/molecules27082498.Search in Google Scholar PubMed PubMed Central

16. Khaerunnisa, S.; Kurniawan, H.; Awaluddin, R.; Suhartati, S.; Soetjipto, S. Potential Inhibitor of COVID-19 Main Protease (Mpro) From Several Medicinal Plant Compounds by Molecular Docking Study 2020. https://doi.org/10.20944/preprints202003.0226.v1.Search in Google Scholar

17. Im, S.-E.; Seo, J.-J.; Park, H. R.; Bark, K. M. Spectroscopic Properties of Quercetin in AOT Reverse Micelles. Bull. Korean Chem. Soc. 2014, 35 (3), 828–832. https://doi.org/10.5012/BKCS.2014.35.3.828.Search in Google Scholar

18. Alva-Ensastegui, J. C.; Palomar-Pardavé, M.; Romero-Romo, M.; Ramírez-Silva, M. T. Quercetin Spectrofluorometric Quantification in Aqueous Media Using Different Surfactants as Fluorescence Promoters. RSC Adv. 2018, 8, 10980–10986. https://doi.org/10.1039/c8ra01213j.Search in Google Scholar PubMed PubMed Central

19. Labidi, S.; Jia, Z.; Amar, M. B.; Chhor, K.; Kanaev, A. Nucleation and Growth Kinetics of Zirconium-Oxo-Alkoxy Nanoparticles. Phys. Chem Chem. Phys. 2015, 17, 2651–2659. https://doi.org/10.1039/c4cp05149a.Search in Google Scholar PubMed

20. Sanchez Mendez, M.; Jia, Z.; Traore, M.; Ben Amar, M.; Nikravech, M.; Kanaev, A. Nucleation and Growth of Mixed Vanadium-Titanium Oxo-Alkoxy Nanoparticles in Sol-Gel Synthesis. Colloids Surf. A: Physicochem. Eng. Asp. 2021, 610, 125636. https://doi.org/10.1016/j.colsurfa.2020.125636.Search in Google Scholar

21. Jia, Z.; Li, J.; Gao, L.; Yang, D.; Kanaev, A. Dynamic Light Scattering: A Powerful Tool for In Situ Nanoparticle Sizing. Colloid Interfac. 2023, 7, 15. https://doi.org/10.3390/colloids7010015.Search in Google Scholar

22. Dynamic Light Scattering, 1993.Search in Google Scholar

23. Yeap, S. P.; Lim, J.; Ngang, H. P.; Ooi, B. S.; Ahmad, A. L. Role of Particle–Particle Interaction towards Effective Interpretation of Z-Average and Particle Size Distributions from Dynamic Light Scattering (DLS) Analysis. J. Nanosci. Nanotechnol. 2018, 18, 6957–6964. https://doi.org/10.1166/jnn.2018.15458.Search in Google Scholar PubMed

24. Stetefeld, J.; McKenna, S. A.; Patel, T. R. Dynamic Light Scattering: A Practical Guide and Applications in Biomedical Sciences. Biophys. Rev. 2016, 8, 409–427. https://doi.org/10.1007/s12551-016-0218-6.Search in Google Scholar PubMed PubMed Central

25. Fischer, K.; Schmidt, M. Pitfalls and Novel Applications of Particle Sizing by Dynamic Light Scattering. Biomaterials 2016, 98, 79–91. https://doi.org/10.1016/j.biomaterials.2016.05.003.Search in Google Scholar PubMed

26. Koppel, D. E. Analysis of Macromolecular Polydispersity in Intensity Correlation Spectroscopy: The Method of Cumulants. J. Chem. Phys. 1972, 57, 4814–4820. https://doi.org/10.1063/1.1678153.Search in Google Scholar

27. Berne, B. J.; Pecora, R. Dynamic Light Scattering: With Applications to Chemistry, Biology, and Physics; Dover Publications, INC.: Mineola, New York, 2000.Search in Google Scholar

28. Eskici, G.; Axelsen, P. H. The Size of AOT Reverse Micelles. J. Phys. Chem. B 2016, 120, 11337–11347. https://doi.org/10.1021/acs.jpcb.6b06420.Search in Google Scholar PubMed PubMed Central

29. Bohidar, H. B.; Behboudnia, M. Characterization of Reverse Micelles by Dynamic Light Scattering. Colloids Surf. A: Physicochem. Eng. Asp. 2001, 178, 313–323. https://doi.org/10.1016/s0927-7757(00)00736-6.Search in Google Scholar

30. Vasquez, V. R.; Williams, B. C.; Graeve, O. A. Stability and Comparative Analysis of AOT/Water/Isooctane Reverse Micelle System Using Dynamic Light Scattering and Molecular Dynamics. J. Phys. Chem. B 2011, 115, 2979–2987. https://doi.org/10.1021/jp109202f.Search in Google Scholar PubMed

31. Van Dijk, M. A.; Joosten, J. G. H.; Levine, Y. K.; Bedeaux, D. Dielectric Study of Temperature-dependent Aerosol OT/Water/Isooctane Microemulsion Structure. J. Phys. Chem. 1989, 93, 2506–2512. https://doi.org/10.1021/j100343a054.Search in Google Scholar

32. Güzeloğlu, A.; Bhattarai, A.; Wilczura-Wachnik, H. Interactions between Quercetin and Surfactants/solvents. Results in Chemistry 2024, 8, 101573. https://doi.org/10.1016/j.rechem.2024.101573.Search in Google Scholar

Received: 2024-03-29
Accepted: 2024-07-13
Published Online: 2024-08-13
Published in Print: 2024-09-25

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 18.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/tsd-2024-2596/html?lang=en
Scroll to top button