Determination of resveratrol in nanoformulations using UV-spectroscopy: forced degradation and drug entrapment
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Bhavna Sonule
Miss Bhavna Sonule pursuing her M.S. (Pharm.) in Pharmaceutics from National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. She is now in her final semester and will be completing her master’s in June 2024. Her area of research work is novel drug delivery systems especially drug targeting to the breast tumor.
Mr Nikhil Mehetre pursuing his M.S. (Pharm.) in Pharmaceutics from National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. He is now in his final semester and will be completing his master’s in June 2024. His area of research work is drug targeting in the brain.
Dr. Lalit Kumar obtained his PhD in Pharmaceutical Sciences from Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India in 2016. He has 2 Indian patents, filed 6 patents, published 2 books, published more than 30 book chapters and around 120 articles in peer reviewed journals. He has about 15 years of teaching and research experience. His work includes novel drug delivery systems (especially nanoformulations), analytical methods development, and QbD. He has successfully completed more than ten research projects funded by the AICTE, New Delhi, Karnataka state VGST, Bengaluru, ICMR, New Delhi, SERB, New Delhi. Presently, he is an Assistant Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India.
Abstract
Dietary polyphenols from plant sources play an important role in the human diet. They have various biological effects, such as protein kinase inhibition, antibacterial, anticancer, antiulcer, antiarthritic, and anti-angiogenic properties. Among the various phenolic chemicals found in plants, resveratrol (trans-3,5,4′-trihydroxystilbene) (RVT) is a non-flavonoid polyphenolic compound that has been extensively studied for its health-promoting advantages, including its anti-cancer, neuroprotective, anti-inflammatory, antioxidant, and cardio-protective activities. Considering its potential in pharmaceutical nanoformulations, a rapid, economical, sensitive, and robust UV spectrophotometric method was developed and validated. The proposed method was developed in phosphate buffer at pH 7.4 to estimate the RVT content in the pharmaceutical nanoformulation. The method was developed at a reported wavelength of 306 nm. The developed method was validated according to ICH Q2A (R1) guidelines and was applied for the estimation of RVT in prepared nanoformulations. The method showed exceptional linearity in the range of (1–6) μg mL−1 with a coefficient of determinant value of 0.9998. The study proves that the developed method is linear, precise, sensitive, robust, reproducible, and accurate. This method can be applied for the estimation of RVT in nanoformulations and other bulk dosage forms.
About the authors
Miss Bhavna Sonule pursuing her M.S. (Pharm.) in Pharmaceutics from National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. She is now in her final semester and will be completing her master’s in June 2024. Her area of research work is novel drug delivery systems especially drug targeting to the breast tumor.
Mr Nikhil Mehetre pursuing his M.S. (Pharm.) in Pharmaceutics from National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India. He is now in his final semester and will be completing his master’s in June 2024. His area of research work is drug targeting in the brain.
Dr. Lalit Kumar obtained his PhD in Pharmaceutical Sciences from Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India in 2016. He has 2 Indian patents, filed 6 patents, published 2 books, published more than 30 book chapters and around 120 articles in peer reviewed journals. He has about 15 years of teaching and research experience. His work includes novel drug delivery systems (especially nanoformulations), analytical methods development, and QbD. He has successfully completed more than ten research projects funded by the AICTE, New Delhi, Karnataka state VGST, Bengaluru, ICMR, New Delhi, SERB, New Delhi. Presently, he is an Assistant Professor in the Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hajipur, Bihar, India.
Acknowledgments
The authors are thankful to National Institute of Pharmaceutical Education and Research (NIPER), Hajipur, Vaishali, Bihar, India, for providing all the necessary facilities to complete this work.
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Research ethics: Not applicable.
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Author contributions: Bhavna Sonule: Literature search, data collection, analysis or interpretation, manuscript writing; Nikhil Mehetre: Data collection or processing, analysis or interpretation; Lalit Kumar: Conceptualization, concept, design, writing-review and editing, supervision, resources.
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Competing interests: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The raw data may be obtained on request basis.
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Articles in the same Issue
- Frontmatter
- Review Articles
- A mini review on the applications of artificial intelligence (AI) in surface chemistry and catalysis
- A critical review on scale-up strategies of biosurfactant production and its applications
- Physical Chemistry
- Adsorption of single and mixed surfactants consisting of cocoamidopropyl betaine (CAPB) and sodium dodecyl benzene sulfonate (SDBS) onto zinc surface
- Application
- Study on modified graphene oxide-based emulsion cleaner for oily sludge
- Gemini Surfactants
- Interactions between diester amide Gemini surfactants and polymers, and their application in hair dyes
- Surface Active Ionic Liquids
- Thermodynamic characteristics and aggregation behavior of surface active ionic liquids in presence of vitamin B7 (biotin)
- Drug Delivery System
- Determination of resveratrol in nanoformulations using UV-spectroscopy: forced degradation and drug entrapment
- Detergent Ingredients
- Thermodynamic and surface active investigations of aqueous solution of sodium dodecylbenzene sulfonate in presence of builders: sequestration of Ca2+ ions and interaction with H2O2
Articles in the same Issue
- Frontmatter
- Review Articles
- A mini review on the applications of artificial intelligence (AI) in surface chemistry and catalysis
- A critical review on scale-up strategies of biosurfactant production and its applications
- Physical Chemistry
- Adsorption of single and mixed surfactants consisting of cocoamidopropyl betaine (CAPB) and sodium dodecyl benzene sulfonate (SDBS) onto zinc surface
- Application
- Study on modified graphene oxide-based emulsion cleaner for oily sludge
- Gemini Surfactants
- Interactions between diester amide Gemini surfactants and polymers, and their application in hair dyes
- Surface Active Ionic Liquids
- Thermodynamic characteristics and aggregation behavior of surface active ionic liquids in presence of vitamin B7 (biotin)
- Drug Delivery System
- Determination of resveratrol in nanoformulations using UV-spectroscopy: forced degradation and drug entrapment
- Detergent Ingredients
- Thermodynamic and surface active investigations of aqueous solution of sodium dodecylbenzene sulfonate in presence of builders: sequestration of Ca2+ ions and interaction with H2O2
