Startseite Vision impairment after traumatic brain injury: present knowledge and future directions
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Vision impairment after traumatic brain injury: present knowledge and future directions

  • Mahasweta Das ORCID logo , Xiaolan Tang , Shyam S. Mohapatra und Subhra Mohapatra EMAIL logo
Veröffentlicht/Copyright: 18. September 2018
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Abstract

Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the USA as well as in the world. As a result of TBI, the visual system is also affected often causing complete or partial visual loss, which in turn affects the quality of life. It may also lead to ocular motor dysfunction, defective accommodation, and impaired visual perception. As a part of the therapeutic strategy, early rehabilitative optometric intervention is important. Orthoptic therapy, medication, stem cell therapy, motor and attention trainings are the available treatment options. Gene therapy is one of the most promising emerging strategies. Use of state-of-the-art nanomedicine approaches to deliver drug(s) and/or gene(s) might enhance the therapeutic efficacy of the present and future modalities. More research is needed in these fields to improve the outcome of this debilitating condition. This review focuses on different visual pathologies caused by TBI, advances in pre-clinical and clinical research, and available treatment options.

Acknowledgments

This work is supported by Veterans Affairs Merit Review grant (BX002668) to Subhra Mohapatra, and Research Career Scientist Awards to Dr. Subhra Mohapatra (IK6BX004212) and Dr. Shyam Mohapatra (IK6 BX003778). Though this report is based upon work supported in part by the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, the contents of this report do not represent the views of the Department of Veterans Affairs or the United States Government.

  1. Conflict of interest statement: The authors of this article have no competing interest to declare.

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Received: 2018-02-15
Accepted: 2018-06-15
Published Online: 2018-09-18
Published in Print: 2019-04-24

©2019 Walter de Gruyter GmbH, Berlin/Boston

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