Abstract
The neurokinin 1 receptor with the natural substrate substance P is one of the intensely studied receptors among the neurokinin receptors. The intracellular signaling mechanism uses G protein-coupled transduction regulating various physiological processes from nausea to Alzheimer’s disease. The neurokinin 1 receptor plays a significant role in neuroinflammation-mediated alterations in neural circuitry. Neurokinin 1 receptor antagonists are selective, potent and exhibited efficacy in animal models of nervous system disorders. Evolving data now strengthen the viewpoint of brain substance P/neurokinin 1 receptor axis-mediated action in neural circuit dysfunction. Thus, a deep-rooted analysis of disease mechanism in which the neurokinin 1 receptor is involved is necessary for augmenting disease models which encourage the pharmaceutical industry to intensify the research pipeline. This review is an attempt to outline the concept of neurokinin 1 receptor signaling interlinked to the brain innate immune system. We also uncover the mechanisms of the neurokinin 1 receptor involved in neurological disorder and various methods of modulating the neurokinin 1 receptor, which may result in therapeutic action.
Acknowledgment
We thank Manipal Academy of Higher Education (MAHE), Manipal, India, for providing facilities to support the study.
Conflicts of interest statement: The authors have no conflicts of interest to declare.
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Cortical and meningeal pathology in progressive multiple sclerosis: a new therapeutic target?
- Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders
- The optimal choices of animal models of white matter injury
- Beta-propeller protein-associated neurodegeneration (BPAN) as a genetically simple model of multifaceted neuropathology resulting from defects in autophagy
- Progress in research on the role of Omi/HtrA2 in neurological diseases
- GABAergic modulation of serotonergic neurons in the dorsal raphe nucleus
- Vision impairment after traumatic brain injury: present knowledge and future directions
- Effects of stress on the auditory system: an approach to study a common origin for mood disorders and dementia
- Understanding the role of dopamine in conditioned and unconditioned fear
Artikel in diesem Heft
- Frontmatter
- Cortical and meningeal pathology in progressive multiple sclerosis: a new therapeutic target?
- Crosstalk between neurokinin receptor signaling and neuroinflammation in neurological disorders
- The optimal choices of animal models of white matter injury
- Beta-propeller protein-associated neurodegeneration (BPAN) as a genetically simple model of multifaceted neuropathology resulting from defects in autophagy
- Progress in research on the role of Omi/HtrA2 in neurological diseases
- GABAergic modulation of serotonergic neurons in the dorsal raphe nucleus
- Vision impairment after traumatic brain injury: present knowledge and future directions
- Effects of stress on the auditory system: an approach to study a common origin for mood disorders and dementia
- Understanding the role of dopamine in conditioned and unconditioned fear