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Co-transplantation of autologous OM-MSCs and OM-OECs: a novel approach for spinal cord injury

  • Lite Ge , Kai Liu , Zhonghua Liu EMAIL logo and Ming Lu EMAIL logo
Published/Copyright: November 17, 2015
Become an author with De Gruyter Brill

Abstract

Spinal cord injury (SCI) is a disastrous injury that leads to motor and sensory dysfunctions in patients. In recent years, co-transplantation has become an increasingly used therapeutic treatment for patients with SCI. Both mesenchymal stem cells (MSCs) and olfactory-ensheathing cells (OECs) have been adopted to ameliorate SCI, with promising outcomes. Remarkable effects on the rehabilitation of patients with SCI have been achieved using MSCs. Olfactory mucosa (OM) MSCs from human OM are one of the most ideal cell resources for auto-transplantation in clinical application owing to their a high proliferation rate and multipotent capability. In addition, OECs derived from OM have been used to improve functional recovery of SCI and resulted in promising functional recovery in years. Accordingly, co-transplantation of OM-MSCs coupled with OM-OECs has been adopted to improve the recovery of SCI. Here we reviewed the reported applications of OM-MSCs and OM-OECs for SCI treatment and proposed that a novel combined strategy using both autologous OM-MSCs and OM-OECs would achieve a better approach for the treatment of SCI.


Corresponding authors: Zhonghua Liu, College of Life Sciences, Hunan Normal University, Changsha 410008, P.R. China, e-mail: ; and Ming Lu, Department of Neurosurgery, Second Affiliated Hospital of Hunan Normal University (163 Hospital of PLA), Changsha 410003, P.R. China, e-mail:
aLite Ge and Kai Liu: These authors contributed equally to this article.

Acknowledgments

The authors thank all the contract grant sponsors: National Natural Science Foundation of China (contract grant number 81371358), Hunan Provincial Natural Science of Foundation of China (contract grant number 14JJ2060), and Hunan Provincial Innovation Foundation for Postgraduate (contract grant number CX2014B237).

Conflict of interest statement: L.G., K.L., ZH.L. and M.L. have no financial and personal relationships with other people or organizations that could inappropriately influence (bias) this work.

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Received: 2015-7-15
Accepted: 2015-10-9
Published Online: 2015-11-17
Published in Print: 2016-4-1

©2016 by De Gruyter

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