Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling
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Su Mi Park
Dr. Su Mi Park received her BS degree in psychology from the University of Maryland and her PhD degree from the Department of Psychology at the University of Virginia in 2012. She studied the role of neuroimmune interactions with behavior for her MA degree. Dr. Park has examined the role of norepinephrine and serotonin in neural circuits underlying the development of conditioned fear and in extinction learning. Her current research interests are in molecular signal interactions under pathological neuronal conditions that can lead to emotional and cognitive problems.
Dr. Cedric L. Williams is a professor in the Neuroscience and Behavior Division of the Psychology Department at the University of Virginia. A major focus of his research is to understand how brainstem nuclei that receive synaptic input regarding changes in peripheral autonomic states after emotional arousal affect memory formation. Experiments conducted in his laboratory use neurochemical, behavioral, and immunohistochemical techniques to examine the functional relevance of anatomical connections between the nucleus of the solitary tract, the amygdala, the prefrontal cortex, and the hippocampus during the memory storage processes. Dr. Williams has received the Alumni Achievement Award from APA’s Diversity in Neuroscience Program and the Director’s Achievement Award for Broadening Participation from the National Science Foundation and is a current National Advisory Board member for Broadening the Representation of Academic Investigators in Neuroscience (BRAINS).
Abstract
The changes in serotonin type 3 (5-HT3) receptor activity influence memory and emotional regulation, the two essential components underlying the successful extinction of conditioned fear. These studies determined if blocking 5-HT3 receptors with granisetron influences the extinction of fear in male Sprague-Dawley rats. In Experiment 1, preextinction granisetron (0.5 or 1.0 mg/kg intraperitoneally) did not affect cued extinction learning but enhanced memory for the extinction session on retention test given 24 and 48 h later. In Experiment 2, granisetron injections given on days 1 and 4 during 6 days of extinction training reduced fear produced by contextual fear conditioning. Experiments 3 and 4 examined if 5-HT3 antagonists influence extinction memory by interactions with γ-aminobutyric acid (GABA). The expression of the GABAA receptor clustering protein gephyrin was significantly elevated in the amygdala after cued fear extinction training and a subsequent extinction retention test given 24 h later. Gephyrin expression in the hippocampus but not in the amygdala or the medial prefrontal cortex was significantly reduced after contextual fear extinction sessions given 1 or 5 days after training. The current studies reveal the beneficial effects of 5-HT3 receptor activity in improving new learning associated with extinction of fearful memories and suggest that these actions could be mediated through influences on central GABAergic systems.
About the authors
Dr. Su Mi Park received her BS degree in psychology from the University of Maryland and her PhD degree from the Department of Psychology at the University of Virginia in 2012. She studied the role of neuroimmune interactions with behavior for her MA degree. Dr. Park has examined the role of norepinephrine and serotonin in neural circuits underlying the development of conditioned fear and in extinction learning. Her current research interests are in molecular signal interactions under pathological neuronal conditions that can lead to emotional and cognitive problems.
Dr. Cedric L. Williams is a professor in the Neuroscience and Behavior Division of the Psychology Department at the University of Virginia. A major focus of his research is to understand how brainstem nuclei that receive synaptic input regarding changes in peripheral autonomic states after emotional arousal affect memory formation. Experiments conducted in his laboratory use neurochemical, behavioral, and immunohistochemical techniques to examine the functional relevance of anatomical connections between the nucleus of the solitary tract, the amygdala, the prefrontal cortex, and the hippocampus during the memory storage processes. Dr. Williams has received the Alumni Achievement Award from APA’s Diversity in Neuroscience Program and the Director’s Achievement Award for Broadening Participation from the National Science Foundation and is a current National Advisory Board member for Broadening the Representation of Academic Investigators in Neuroscience (BRAINS).
©2012 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
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- Guest Editorial
- Special Issue: The emotional brain and its relation to psychopathology
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- Serotonin and emotion, learning and memory
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- Estrogen, cognitive functions and emotion: an overview on humans, non-human primates and rodents in reproductive years
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- Emotional modulation of multiple memory systems: implications for the neurobiology of post-traumatic stress disorder
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