Interplay of amygdala and insular cortex during and after associative taste aversion memory formation
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Kioko Guzmán-Ramos
Kioko Guzmán-Ramos received her BS in Biopharmaceutical Chemistry from the National University of Mexico and later she received a PhD in Biomedical Sciences from the same university in 2010. She is currently a postdoctoral fellow at the Texas A&M University in Dr. Federico Bermudez-Rattoni’s lab, where her studies have focused on the mechanisms underlying memory formation, storage, and retrieval, specially under taste memory paradigms using
in vivo microdialysis as the main tool to relate neurochemical changes in the brain with the acquisition of information. A very important part of understanding such mechanisms is to analyze how memory can be impaired in some cognitive dysfunctions such as Alzheimer’s disease.Federico Bermúdez-Rattoni studied medicine at the Universidad Nacional Autónoma de México (UNAM) in Mexico City and received his PhD from the University of California, Los Angeles, in 1984. He then established his own laboratory at the Department of Neuroscience in the Instituto de Fisiología Celular at UNAM in Mexico City. Ever since, he has worked on the molecular mechanisms involved in recognition memory formation. During his career, he has written more than 120 papers and four books. He serves on several scientific advisory committees and editorial boards. He was the president of the Mexican Society for Neuroscience from 2008 to 2011. He became a Visiting Fellow in the Center for The Neurobiology of Learning and Memory at the University of California, Irvine, in 2007, and recently, he has been working at the Interdisciplinary Life Science Building at Texas A&M University in Texas, USA.
Abstract
The formation and storage of aversively motivated memories is based on plastic changes within the amygdala and other brain structures that are modulated by its activity. One of these structures is the insular cortex, which integrates environmental and interoceptive information such that memory traces can be efficient and rapidly stored. A great example of an aversively motivated learning is the taste aversion paradigm, which involves several changes at the cellular level of the amygdala and the insular cortex in order to be acquired and consolidated. So far, the interplay of these structures was described in terms of their participation during exposure to the stimuli to be associated; however, because of the cellular properties and interconnections between them, their functional interplay may go beyond the acquisition stage and the learning experience might trigger an ongoing engagement of amygdala-insular cortex reactivations in order to store the information.
About the authors
Kioko Guzmán-Ramos received her BS in Biopharmaceutical Chemistry from the National University of Mexico and later she received a PhD in Biomedical Sciences from the same university in 2010. She is currently a postdoctoral fellow at the Texas A&M University in Dr. Federico Bermudez-Rattoni’s lab, where her studies have focused on the mechanisms underlying memory formation, storage, and retrieval, specially under taste memory paradigms using in vivo microdialysis as the main tool to relate neurochemical changes in the brain with the acquisition of information. A very important part of understanding such mechanisms is to analyze how memory can be impaired in some cognitive dysfunctions such as Alzheimer’s disease.
Federico Bermúdez-Rattoni studied medicine at the Universidad Nacional Autónoma de México (UNAM) in Mexico City and received his PhD from the University of California, Los Angeles, in 1984. He then established his own laboratory at the Department of Neuroscience in the Instituto de Fisiología Celular at UNAM in Mexico City. Ever since, he has worked on the molecular mechanisms involved in recognition memory formation. During his career, he has written more than 120 papers and four books. He serves on several scientific advisory committees and editorial boards. He was the president of the Mexican Society for Neuroscience from 2008 to 2011. He became a Visiting Fellow in the Center for The Neurobiology of Learning and Memory at the University of California, Irvine, in 2007, and recently, he has been working at the Interdisciplinary Life Science Building at Texas A&M University in Texas, USA.
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Special Issue: The emotional brain and its relation to psychopathology
- Emotional modulation of the synapse
- Interplay of amygdala and insular cortex during and after associative taste aversion memory formation
- PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo
- Taste and odor recognition memory: the emotional flavor of life
- Intense emotional experiences and enhanced training prevent memory loss induced by post-training amnesic treatments administered to the striatum, amygdala, hippocampus or substantia nigra
- Prefrontal/accumbal catecholamine system processes emotionally driven attribution of motivational salience
- Spatial memory, plasticity and nucleus accumbens
- Serotonin and emotion, learning and memory
- Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling
- Bombesin receptor regulation of emotional memory
- Estrogen, cognitive functions and emotion: an overview on humans, non-human primates and rodents in reproductive years
- Molecular brake pad hypothesis: pulling off the brakes for emotional memory
- Emotional modulation of multiple memory systems: implications for the neurobiology of post-traumatic stress disorder
- Modeling specific phobias and posttraumatic stress disorder in rodents: the challenge to convey both cognitive and emotional features
- Learning to cope with stress: psychobiological mechanisms of stress resilience
- Effects of parabolic flight and spaceflight on the endocannabinoid system in humans
- Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression
- Differences between the aging process and the chronic cerebrovascular impairment of memory functioning: the emotional and cognitive interaction
- A role for the superior colliculus in the modulation of threat responsiveness in primates: toward the ontogenesis of the social brain
- Cannabinoid modulation of mother-infant interaction: is it just about milk?
- Maternal exposure to low levels of corticosterone during lactation increases social play behavior in rat adolescent offspring
- Compulsive drug use and its neural substrates
- The role of the basal ganglia in motivated behavior
- The role of setting for ketamine abuse: clinical and preclinical evidence
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Special Issue: The emotional brain and its relation to psychopathology
- Emotional modulation of the synapse
- Interplay of amygdala and insular cortex during and after associative taste aversion memory formation
- PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo
- Taste and odor recognition memory: the emotional flavor of life
- Intense emotional experiences and enhanced training prevent memory loss induced by post-training amnesic treatments administered to the striatum, amygdala, hippocampus or substantia nigra
- Prefrontal/accumbal catecholamine system processes emotionally driven attribution of motivational salience
- Spatial memory, plasticity and nucleus accumbens
- Serotonin and emotion, learning and memory
- Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling
- Bombesin receptor regulation of emotional memory
- Estrogen, cognitive functions and emotion: an overview on humans, non-human primates and rodents in reproductive years
- Molecular brake pad hypothesis: pulling off the brakes for emotional memory
- Emotional modulation of multiple memory systems: implications for the neurobiology of post-traumatic stress disorder
- Modeling specific phobias and posttraumatic stress disorder in rodents: the challenge to convey both cognitive and emotional features
- Learning to cope with stress: psychobiological mechanisms of stress resilience
- Effects of parabolic flight and spaceflight on the endocannabinoid system in humans
- Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression
- Differences between the aging process and the chronic cerebrovascular impairment of memory functioning: the emotional and cognitive interaction
- A role for the superior colliculus in the modulation of threat responsiveness in primates: toward the ontogenesis of the social brain
- Cannabinoid modulation of mother-infant interaction: is it just about milk?
- Maternal exposure to low levels of corticosterone during lactation increases social play behavior in rat adolescent offspring
- Compulsive drug use and its neural substrates
- The role of the basal ganglia in motivated behavior
- The role of setting for ketamine abuse: clinical and preclinical evidence
