Serotonin and emotion, learning and memory
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Alfredo Meneses
Alfredo Meneses received his Ph.D. on Physiological sciences (1996) from UNAM. He held a postdoctoral position in the NIA, USA from 1997 to 1998. Currently, he is a full Professor in the Department of Pharmacobiology of CINVESTAV and was a visiting Professor at the Laboratory of Neurobiology of Behavior, Universite de Provence Aix-Marseille I, France (1999) and at the Department of Basic and Applied Biology, University of L'Aquila, Italy (2004). His main topics of research are neuropharmacology and neurobiology of memory. He has been a project referee for the Neuroscience and Mental Health Board Medical Research Council, London UK July 2006 and for the Earth & Life Sciences Veni in Holland since 2012. He was a guest editor for a special issue of
Behavioral Brain Research about 5-HT and cognition (2007–2008). He is an Editorial Board member ofFrontiers in Psychopharmacology (2010) andNeuropharmacology (2012). He is a member of the US Society for Neuroscience (since 1991), the Serotonin Club (since 1993), and the Collegium Internationale Neuro-Psychopharmacologicum (since 2002).
and
Gustavo Liy-Salmeron
Abstract
Serotonin (5-hydroxytryptamien, 5-HT) has been linked to emotional and motivational aspects of human behavior, including anxiety, depression, impulsivity, etc. Several clinically effective drugs exert effects via 5-HT systems. Growing evidence suggests that those effects play an important role in learning and memory. Whether the role of serotonin is related to memory and/or behavioral or emotional aspects remains an important question. A key question that remains is whether 5-HT markers (e.g., receptors) directly or indirectly participate and/or contribute to the physiological and pharmacological basis of memory and its pathogenesis. The major aim of this paper is to re-examine some recent advances regarding mammalian 5-HT receptors and transporter in light of their physiological, pathophysiological and therapeutic implications for memory. We particularly address evidence involving 5-HT systems in behavioral, pharmacological, molecular, genetic and imaging results and memory. Finally, this paper aims to summarize a portion of the evidence about serotonin, memory and emotion from animal and human studies and provide an overview of potential tools, markers and cellular and molecular candidate mechanisms. It should be noted that there are several subjects that this paper only briefly touches upon, presenting only what may be the most salient findings in the context of memory, emotion and serotonin.
About the author
Alfredo Meneses received his Ph.D. on Physiological sciences (1996) from UNAM. He held a postdoctoral position in the NIA, USA from 1997 to 1998. Currently, he is a full Professor in the Department of Pharmacobiology of CINVESTAV and was a visiting Professor at the Laboratory of Neurobiology of Behavior, Universite de Provence Aix-Marseille I, France (1999) and at the Department of Basic and Applied Biology, University of L'Aquila, Italy (2004). His main topics of research are neuropharmacology and neurobiology of memory. He has been a project referee for the Neuroscience and Mental Health Board Medical Research Council, London UK July 2006 and for the Earth & Life Sciences Veni in Holland since 2012. He was a guest editor for a special issue of Behavioral Brain Research about 5-HT and cognition (2007–2008). He is an Editorial Board member of Frontiers in Psychopharmacology (2010) and Neuropharmacology (2012). He is a member of the US Society for Neuroscience (since 1991), the Serotonin Club (since 1993), and the Collegium Internationale Neuro-Psychopharmacologicum (since 2002).
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Special Issue: The emotional brain and its relation to psychopathology
- Emotional modulation of the synapse
- Interplay of amygdala and insular cortex during and after associative taste aversion memory formation
- PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo
- Taste and odor recognition memory: the emotional flavor of life
- Intense emotional experiences and enhanced training prevent memory loss induced by post-training amnesic treatments administered to the striatum, amygdala, hippocampus or substantia nigra
- Prefrontal/accumbal catecholamine system processes emotionally driven attribution of motivational salience
- Spatial memory, plasticity and nucleus accumbens
- Serotonin and emotion, learning and memory
- Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling
- Bombesin receptor regulation of emotional memory
- Estrogen, cognitive functions and emotion: an overview on humans, non-human primates and rodents in reproductive years
- Molecular brake pad hypothesis: pulling off the brakes for emotional memory
- Emotional modulation of multiple memory systems: implications for the neurobiology of post-traumatic stress disorder
- Modeling specific phobias and posttraumatic stress disorder in rodents: the challenge to convey both cognitive and emotional features
- Learning to cope with stress: psychobiological mechanisms of stress resilience
- Effects of parabolic flight and spaceflight on the endocannabinoid system in humans
- Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression
- Differences between the aging process and the chronic cerebrovascular impairment of memory functioning: the emotional and cognitive interaction
- A role for the superior colliculus in the modulation of threat responsiveness in primates: toward the ontogenesis of the social brain
- Cannabinoid modulation of mother-infant interaction: is it just about milk?
- Maternal exposure to low levels of corticosterone during lactation increases social play behavior in rat adolescent offspring
- Compulsive drug use and its neural substrates
- The role of the basal ganglia in motivated behavior
- The role of setting for ketamine abuse: clinical and preclinical evidence
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Special Issue: The emotional brain and its relation to psychopathology
- Emotional modulation of the synapse
- Interplay of amygdala and insular cortex during and after associative taste aversion memory formation
- PKMζ inhibition prevents the metaplastic change induced by conditioned taste aversion on insular cortex long-term potentiation in vivo
- Taste and odor recognition memory: the emotional flavor of life
- Intense emotional experiences and enhanced training prevent memory loss induced by post-training amnesic treatments administered to the striatum, amygdala, hippocampus or substantia nigra
- Prefrontal/accumbal catecholamine system processes emotionally driven attribution of motivational salience
- Spatial memory, plasticity and nucleus accumbens
- Serotonin and emotion, learning and memory
- Contribution of serotonin type 3 receptors in the successful extinction of cued or contextual fear conditioned responses: interactions with GABAergic signaling
- Bombesin receptor regulation of emotional memory
- Estrogen, cognitive functions and emotion: an overview on humans, non-human primates and rodents in reproductive years
- Molecular brake pad hypothesis: pulling off the brakes for emotional memory
- Emotional modulation of multiple memory systems: implications for the neurobiology of post-traumatic stress disorder
- Modeling specific phobias and posttraumatic stress disorder in rodents: the challenge to convey both cognitive and emotional features
- Learning to cope with stress: psychobiological mechanisms of stress resilience
- Effects of parabolic flight and spaceflight on the endocannabinoid system in humans
- Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression
- Differences between the aging process and the chronic cerebrovascular impairment of memory functioning: the emotional and cognitive interaction
- A role for the superior colliculus in the modulation of threat responsiveness in primates: toward the ontogenesis of the social brain
- Cannabinoid modulation of mother-infant interaction: is it just about milk?
- Maternal exposure to low levels of corticosterone during lactation increases social play behavior in rat adolescent offspring
- Compulsive drug use and its neural substrates
- The role of the basal ganglia in motivated behavior
- The role of setting for ketamine abuse: clinical and preclinical evidence
