Abstract
97Ru is a key radionuclide sought for diagnostic imaging due to its low-energy and intense γ-rays of 215.7 keV and 324.5 keV. New reaction routes to produce this radionuclide are constantly being investigated. A crucial step in carrying out such reactions is a reliable beforehand estimate of the production cross section of radionuclide and optimization conditions through robust theoretical frameworks. Existing literature on α + 95Mo reaction has been freshly examined to understand the excitation function of 97Ru. The data have been compared to other reactions of different projectiles on medium-mass targets. The reaction codes pace4, empire-3.2.2, and talys-1.96 have been employed to decipher the reaction mechanism and check the predictive ability of underlying theoretical models. The yield of 97Ru at different projectile energies and thick target yield in the optimum energy range has also been determined from the theoretical modeling.
Acknowledgment
MS sincerely thanks the Ministry of Human Resource Development, Government of India, for providing financial support during research.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: Malvika Sagwal: Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft. Moumita Maiti: Conceptualization, Investigation, Visualization, Supervision, Writing – review & editing.
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Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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Research funding: None declared.
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Data availability: Not applicable
References
1. Srivastava, S. C., Som, P., Meinken, G., Sewatkar, A., Ku, T. H. Ruthenium-97 Labeled Compounds – A New Class of Radiopharmaceuticals; Brookhaven National Laboratory Report BNL 24614, 1978.Search in Google Scholar
2. Oster, Z. H., Som, P., Gil, M. C., Fairchild, R. G., Goldman, A. G., Schachner, E. R., Sacker, D. F., Atkins, H. L., Brill, A. B. Ruthenium-97 DTPA: a new radiopharmaceutical for cisternography. J. Nucl. Med. 1981, 22, 269.Search in Google Scholar
3. Schachner, E. R., Gil, M. C., Atkins, H. L., Som, P., Srivastava, S. C., Badia, J., Sacker, D. F., Fairchild, R. G., Richards, P. Ruthenium-97 hepatobiliary agents for delayed studies of the biliary track I: Ru-97 PIPIDA: concise communication. J. Nucl. Med. 1981, 22, 352.Search in Google Scholar
4. Zanzi, I., Srivastava, S. C., Meinken, G. E., Robeson, W., Mausner, L. F., Fairchild, R. G., Margouleff, D. A new cholescintigraphic agent: ruthenium-97-DISIDA. Nucl. Med. 1989, 16, 397; https://doi.org/10.1016/0883-2897(89)90107-4.Search in Google Scholar PubMed
5. Som, P., Oster, Z. H., Matsui, K., Guglielmi, G., Persson, B. R. R., Pellettieri, M. L., Srivastava, S. C., Richards, P., Atkins, H. L., Brill, A. B. 97Ru-transferrin uptake in tumor and abscess. Eur. J. Nucl. Med. 1983, 8, 491; https://doi.org/10.1007/bf00598908.Search in Google Scholar
6. Lagunas-Solar, M. C., Avila, M. J., Nvarro, N. J., Johnson, P. C. Cyclotron production of no-carrier-added 97Ru by proton bombardment of 103Rh targets. Int. J. Appl. Radiat. Isot. 1983, 34, 915; https://doi.org/10.1016/0020-708x(83)90154-0.Search in Google Scholar
7. Kofstad, K. Spallation and Fission of Silver; Lawrence Berkeley National Laboratory Report UCRL 2265, 1953.10.2172/4422757Search in Google Scholar
8. Zaitseva, N. G., Rurarz, E., Vobecky, M., Hwan, K. H., Nowak, K., Tethal, T., Khalkin, V. A., Popinenkova, L. M. Excitation function and yield for 97Ru production in 99Tc(p, 3n) 97Ru reaction in 20–100 MeV proton energy range. Radiochim. Acta 1992, 56, 59; https://doi.org/10.1524/ract.1992.56.2.59.Search in Google Scholar
9. Zaitseva, N. G., Stegailov, V. I., Khalkin, V. A., Shakun, N. G., Shishlyannikov, P. T., Bukov, K. G. Metal technetium target and target chemistry for the production of 97Ru via the 99Tc(p, 3n) 97Ru reaction. Appl. Radiat. Isot. 1996, 47, 145; https://doi.org/10.1016/0969-8043(95)00272-3.Search in Google Scholar
10. Comparetto, G., Qaim, S. M. A comparative study of production of short-lived neutron deficient isotopes 94,95,97Ru in α- and 3He-particle induced nuclear reactions on natural molybdenum. Radiochim. Acta 1980, 27, 177; https://doi.org/10.1524/ract.1980.27.4.177.Search in Google Scholar
11. Comar, D., Crouzel, C. Ruthenium-97 preparation with a compact cyclotron. Radiochem. Radioanal. Lett. 1976, 27, 307.Search in Google Scholar
12. Pao, P. J., Zhou, J. L., Silvester, D. J., Waters, S. L. A rapid and simple separation of 97Ru from irradiated molybdenum. Radiochem. Radioanal. Lett. 1981, 46, 21.Search in Google Scholar
13. Ditrói, F., Hermanne, A., Tárkányi, F., Takács, S., Ignatyuk, A. V. Investigation of α-particle induced reactions on natural molybdenum. Nucl. Instrum. Methods Phys. Res., Sect. B 2012, 285, 125; https://doi.org/10.1016/j.nimb.2012.05.030.Search in Google Scholar
14. Tárkányi, F., Hermanne, A., Ditrói, F., Takács, S., Ignatyuk, A. Investigation of activation cross section data of alpha particle induced nuclear reaction on molybdenum up to 40 MeV: review of production routes of medically relevant 97,103Ru. Nucl. Instrum. Methods Phys. Res., Sect. B 2017, 399, 83; https://doi.org/10.1016/j.nimb.2017.03.043.Search in Google Scholar
15. Sitarz, M., Nigron, E., Guertin, A., Haddad, F., Matulewicz, T. New cross-sections for natMo(α, x) reactions and medical 97Ru production estimations with radionuclide yield calculator. Instruments 2019, 3, 7; https://doi.org/10.3390/instruments3010007.Search in Google Scholar
16. Graf, H. P., Münzel, H. Excitation functions for α-particle reactions with molybdenum isotopes. J. Inorg. Nucl. Chem. 1974, 36, 3647; https://doi.org/10.1016/0022-1902(74)80143-0.Search in Google Scholar
17. Levkovski, V. N. Cross Sections of Medium Mass Nuclide Activation (A=40-100) by Medium Energy Protons and Alpha-Particles (E = 10–50 MeV) (Experiments and systematics), Inter-Vesi :Moscow, USSR,1991 (EXFOR A0510532).Search in Google Scholar
18. Cyclotron Produced Radionuclides. Physical Characteristics and Production Methods; Technical Reports Series No. 468: IAEA, Vienna, 2009; pp. 1–266.Search in Google Scholar
19. Kumar, D., Maiti, M., Lahiri, S. Experimental probe for the production of 97Ru from the 7Li+93Nb reaction: a study of precompound emissions. Phys. Rev. C 2016, 94, 044603; https://doi.org/10.1103/physrevc.94.044603.Search in Google Scholar
20. Pandit, S. K., Shrivastava, A., Mahata, K., Parkar, V. V., Palit, R., Keeley, N., Rout, P. C., Kumar, A., Ramachandran, K., Bhattacharyya, S., Nanal, V., Palshetkar, C. S., Nag, T. N., Gupta, S., Biswas, S., Saha, S., Sethi, J., Singh, P., Chatterjee, A., Kailas, S. Investigation of large α production in reactions involving weakly bound 7Li. Phys. Rev. C 2017, 96, 044616; https://doi.org/10.1103/physrevc.96.044616.Search in Google Scholar
21. Kumar, D., Maiti, M. Measurement of the cross section of the residues from the 11B-induced reaction on 89Y and 93Nb: production of 97Ru and 101mRh. Phys. Rev. C 2017, 95, 064602.Search in Google Scholar
22. Chauhan, A., Maiti, M. Measurement and analysis of excitation functions of the residues from 12C+89Y: a major production route for 97Ru. Phys. Rev. C 2019, 99, 064609; https://doi.org/10.1103/physrevc.99.064609.Search in Google Scholar
23. Sagwal, M., Maiti, M., Nag, T. N., Sodaye, S. New measurement of residues from 12C+93Nb by the activation technique: a closer look at the reaction mechanisms. Eur. Phys. J. Plus 2021, 136, 1057; https://doi.org/10.1140/epjp/s13360-021-01981-0.Search in Google Scholar
24. Maiti, M., Lahiri, S. Production and separation of 97Ru from 7Li activated natural niobium. Radiochim. Acta 2011, 99, 359; https://doi.org/10.1524/ract.2011.1831.Search in Google Scholar
25. Maiti, M. Production and separation of 97Ru and coproduced 95Tc from 12C-induced reaction on yttrium target. Radiochim. Acta 2013, 101, 437; https://doi.org/10.1524/ract.2013.2048.Search in Google Scholar
26. Maiti, M., Lahiri, S. Measurement of yield of residues produced in 12C+natY reaction and subsequent separation of 97Ru from Y target using cation exchange resin. Radiochim. Acta 2015, 103, 7; https://doi.org/10.1515/ract-2014-2277.Search in Google Scholar
27. Kumar, D., Maiti, M., Lahiri, S. Production of no-carrier-added 97Ru from 11B activated natural yttrium target and its subsequent separation using liquid-liquid extraction. Sep. Sci. Technol. 2017, 52, 2372; https://doi.org/10.1080/01496395.2017.1279179.Search in Google Scholar
28. Maiti, M. Nuclear and chemical data for life sciences. J. Radioanal. Nucl. Chem. 2013, 297, 319; https://doi.org/10.1007/s10967-012-2345-2.Search in Google Scholar
29. Hauser, W., Feshbach, H. The inelastic scattering of neutrons. Phys. Rev. 1952, 87, 2; https://doi.org/10.1103/physrev.87.366.Search in Google Scholar
30. Perey, C. M., Perey, F. G. Compilation of phenomenological optical-model parameters. At. Data Nucl. Data Tables 1976, 17, 1; https://doi.org/10.1016/0092-640x(76)90007-3.Search in Google Scholar
31. Bass, R. Nucleus-nucleus potential deduced from experimental fusion cross sections. Phys. Rev. Lett. 1977, 39, 265; https://doi.org/10.1103/physrevlett.39.265.Search in Google Scholar
32. Gavron, A. Statistical model calculations in heavy ion reactions. Phys. Rev. C 1980, 21, 230; https://doi.org/10.1103/physrevc.21.230.Search in Google Scholar
33. Gilbert, A., Cameron, A. G. W. A composite nuclear-level density formula with shell corrections. Can. J. Phys. 1965, 43, 1446; https://doi.org/10.1139/p65-139.Search in Google Scholar
34. Sierk, A. J. Macroscopic model of rotating nuclei. Phys. Rev. C 1986, 33, 2039; https://doi.org/10.1103/physrevc.33.2039.Search in Google Scholar PubMed
35. Hill, D. L., Wheeler, J. A. Nuclear constitution and the interpretation of fission phenomena. Phys. Rev. 1953, 89, 1102; https://doi.org/10.1103/physrev.89.1102.Search in Google Scholar
36. Herman, M., Capote, R., Carlson, B. V., Obložinský, P., Sin, M., Trkov, A., Wienke, H., Zerkin, V. EMPIRE: nuclear reaction model code system for data evaluation. Nucl. Data Sheets 2007, 108, 2655; https://doi.org/10.1016/j.nds.2007.11.003.Search in Google Scholar
37. Griffin, J. J. Statistical model of intermediate structure. Phys. Rev. Lett. 1966, 17, 478; https://doi.org/10.1103/physrevlett.17.478.Search in Google Scholar
38. Cline, C. K., Blann, M. The preequilibrium statistical model: description of the nuclear equilibration process and parameterization of the model. Nucl. Phys. A 1971, 172, 225; https://doi.org/10.1016/0375-9474(71)90713-5.Search in Google Scholar
39. Ignatyuk, A. V., Weil, J. L., Raman, S., Kahane, S. Density of discrete levels in 116Sn. Phys. Rev. C 1993, 47, 1504; https://doi.org/10.1103/physrevc.47.1504.Search in Google Scholar PubMed
40. Capote, R., Herman, M., Obložinský, P., Young, P. G., Goriely, S., Belgya, T., Ignatyuk, A. V., Koning, A. J., Hilaire, S., Plujko, V. A., Avrigeanu, M., Bersillon, O., Chadwick, M. B., Fukahori, T., Ge, Z., Han, Y., Kailas, S., Kopecky, J., Maslov, V. M., Reffo, G., Sin, M., Soukhovitskii, E. S., Talou, P. RIPL – reference Input Parameter Library for calculation of nuclear reactions and nuclear data evaluation. Nucl. Data Sheets 2009, 110, 3107; https://doi.org/10.1016/j.nds.2009.10.004.Search in Google Scholar
41. Koning, A. J., Hilaire, S., Goriely, S. User Manual-talys-1.96/2.0/Simulation of Nuclear Data; Tech. rep.: Vienna, 2021.Search in Google Scholar
42. Avrigeanu, V., Avrigeanu, M., Mihaelescu, C. Further explorations of the α-particle optical model potential at low energies for the mass range A ≈ 45–209. Phys. Rev. C 2014, 90, 044612; https://doi.org/10.1103/physrevc.90.044612.Search in Google Scholar
43. Weisskopf, V. Statistics and nuclear reactions. Phys. Rev. 1937, 52, 295; https://doi.org/10.1103/physrev.52.295.Search in Google Scholar
44. Sharma, M. K., Singh, P. P., Singh, D. P., Yadav, A., Sharma, V. R., Bala, I., Kumar, R., UnnatiSingh, B. P., Prasad, R. Systematic study of preequilibrium emission at low energies in 12C- and 16O-induced reactions. Phys. Rev. C 2015, 91, 014603; https://doi.org/10.1103/physrevc.91.014603.Search in Google Scholar
45. Otuka, N., Takács, S. Definitions of radioisotope thick target yields. Radiochim. Acta 2015, 103, 1; https://doi.org/10.1515/ract-2013-2234.Search in Google Scholar
46. Qaim, S. M. Nuclear data relevant to cyclotron produced short-lived medical radioisotopes. Radiochim. Acta 1982, 30, 147.Search in Google Scholar
© 2023 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Preface
- NUCAR-2023: Foreword
- Research Articles
- Theoretical analysis of light and heavy-ion induced reactions: production of medically relevant 97Ru
- Excitation functions of alpha-particle induced nuclear reactions on nat Sn
- Non-destructive assay of plutonium in absence of gamma-ray spectrometry
- Catalytic destruction of oxalate in the supernatant stream generated during plutonium reconversion process
- Quantification of Zr in simulated dissolver solution of U–Zr fuel by laser-induced breakdown spectroscopy
- Radiochemical and chemical characterization of fuel, salt, and deposit from the electrorefining of irradiated U-6 wt% Zr in hot cells
- Zirconium sponge production: an integrated approach for chemical characterization of process intermediates using ICP-OES
- Determination of 10B/11B in boric acid and B4C using LA-ICPMS
- Evaluating sustainability of Bhuj aquifer system, Western India using nuclear dating techniques
- Nanocrystalline Ce(OH)4-based materials: ruthenium selective adsorbent for highly alkaline radioactive liquid waste
- Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron
- Preparation of [64Cu]Cu–NOTA complex as a potential renal PET imaging agent using 64Cu produced via the direct activation route
- Total chemical synthesis of PSMA-617: an API for prostate cancer endotherapeutic applications
- Rapid screening technique for gross α and gross β estimations in aqueous samples during radiation emergency
- Development of Dy3+ doped lithium magnesium borate glass system for thermoluminescence based neutron dosimetry applications
Articles in the same Issue
- Frontmatter
- Preface
- NUCAR-2023: Foreword
- Research Articles
- Theoretical analysis of light and heavy-ion induced reactions: production of medically relevant 97Ru
- Excitation functions of alpha-particle induced nuclear reactions on nat Sn
- Non-destructive assay of plutonium in absence of gamma-ray spectrometry
- Catalytic destruction of oxalate in the supernatant stream generated during plutonium reconversion process
- Quantification of Zr in simulated dissolver solution of U–Zr fuel by laser-induced breakdown spectroscopy
- Radiochemical and chemical characterization of fuel, salt, and deposit from the electrorefining of irradiated U-6 wt% Zr in hot cells
- Zirconium sponge production: an integrated approach for chemical characterization of process intermediates using ICP-OES
- Determination of 10B/11B in boric acid and B4C using LA-ICPMS
- Evaluating sustainability of Bhuj aquifer system, Western India using nuclear dating techniques
- Nanocrystalline Ce(OH)4-based materials: ruthenium selective adsorbent for highly alkaline radioactive liquid waste
- Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron
- Preparation of [64Cu]Cu–NOTA complex as a potential renal PET imaging agent using 64Cu produced via the direct activation route
- Total chemical synthesis of PSMA-617: an API for prostate cancer endotherapeutic applications
- Rapid screening technique for gross α and gross β estimations in aqueous samples during radiation emergency
- Development of Dy3+ doped lithium magnesium borate glass system for thermoluminescence based neutron dosimetry applications