99mTc(I) carbonyl-radiolabeled lipid based drug carriers for temozolomide delivery and bioevaluation by in vitro and in vivo
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Kadir Arı
Abstract
In preclinical research radiolabeled nanoparticles have been attracting interest as a new class of imaging probes. Assuming good stability of solid lipid nanoparticles (SLNs) under physiological conditions, radiolabeled SLNs can be used for imaging and measuring uptake in target tissue. Present study was performed to evaluate biological behavior of temozolomide (TMZ) loaded solid lipid nanoparticles (SLN-TMZ) in vivo and in vitro. Lipid nanoparticles were prepared by emulsification and low-temperature solidification method. ζ potential, morphology and particle size of nanoparticles were determined. Biological behavior of 99mTc(CO)3+ radiolabeled SLN-TMZ were investigated in vitro on U87/Daoy cell lines and in vivo on female Wistar Albino rats. Obtained results of in vitro incorporation, in vivo biodistribution and gamma imaging studies on radiolabeled SLN-TMZ show that the radiolabeled solid lipid nanoparticles could have potential as a drug delivery system for TMZ.
Disclosure statement: This study was funded by The Scientific Technological Research Council of Turkey (TUBITAK, Project no: 113S369) and Ege University Science and Technology Centre (EBILTEM, Project no: 2014BIL035).
References
1. Kaur, I. P., Bhandari, R., Bhandari, S., Kakkar, V.: Potential of solid lipid nanoparticles in brain targeting. J. Control. Release. 127, 97 (2008).10.1016/j.jconrel.2007.12.018Search in Google Scholar PubMed
2. Qiao, R., Jia, Q., Hüwel, S., Xia, R., Liu, T., Gao, F., Galla, H.-J., Gao, M.: Receptor-Mediated Delivery of Magnetic Nanoparticles across the Blood–Brain Barrier. ACS Nano. 6, 3304 (2012).10.1021/nn300240pSearch in Google Scholar PubMed
3. Ucar, E., Teksoz, S., Ichedef, C., Kilcar, A. Y., Medine, E. I., Ari, K., Parlak, Y., Sayit Bilgin, B. E., Unak, P.: Synthesis, characterization and radiolabeling of folic acid modified nanostructured lipid carriers as a contrast agent and drug delivery system. Appl. Radiat. Isot. 119, 72 (2017).10.1016/j.apradiso.2016.11.002Search in Google Scholar PubMed
4. Wissing, S., Kayser, O., Müller, R.: Solid lipid nanoparticles for parenteral drug delivery. Adv. Drug Deliv. Rev. 56, 1257 (2004).10.1016/j.addr.2003.12.002Search in Google Scholar PubMed
5. Esteller, M.: Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes. Eur. J. Cancer. 36, 2294 (2000).10.1016/S0959-8049(00)00303-8Search in Google Scholar PubMed
6. Huang, G., Zhang, N., Bi, X., Dou, M.: Solid lipid nanoparticles of temozolomide: potential reduction of cardial and nephric toxicity. Int. J. Pharm. 355, 314 (2008).10.1016/j.ijpharm.2007.12.013Search in Google Scholar PubMed
7. Laquintana, V., Trapani, A., Denora, N., Wang, F., Gallo, J. M., Trapani, G.: New strategies to deliver anticancer drugs to brain tumors. Expert Opin. Drug Deliv. 6, 1017 (2009).10.1517/17425240903167942Search in Google Scholar PubMed PubMed Central
8. Kreuter, J.: Nanoparticulate systems for brain delivery of drugs. Adv. Drug Deliv. Rev. 64, 213 (2001).10.1016/j.addr.2012.09.015Search in Google Scholar
9. Bondì, M. L., Craparo, E. F., Giammona, G., Drago, F.: Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution. Nanomedicine 5, 25 (2010).10.2217/nnm.09.67Search in Google Scholar PubMed
10. Alberto, R., Schibli, R., Egli, A., Schubiger, A. P., Abram, U., Kaden, T. A.: A novel organometallic aqua complex of technetium for the labeling of biomolecules: synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in aqueous solution and its reaction with a bifunctional ligand. J. Am. Chem. Soc. 120, 7987 (1998).10.1021/ja980745tSearch in Google Scholar
11. Kim, H., Likhari, P., Parker, D., Statkevich, P., Marco, A., Lin, C. C., Nomeir, A. A.: High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma. J. Pharm. Biomed. Anal. 24, 461 (2001).10.1016/S0731-7085(00)00466-0Search in Google Scholar PubMed
12. Kovačević, A. B., Müller, R. H., Savić, S. D., Vuleta, G. M., Keck, C. M.: Solid lipid nanoparticles (SLN) stabilized with polyhydroxy surfactants: preparation, characterization and physical stability investigation. Colloids Surf. A Physicochem. Eng. Asp. 444, 15 (2014).10.1016/j.colsurfa.2013.12.023Search in Google Scholar
13. Venkateswarlu, V., Manjunath, K.: Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J. Control. Release. 95, 627 (2004).10.1016/j.jconrel.2004.01.005Search in Google Scholar PubMed
14. Schubert, M. A., Müller-Goymann, C. C.: Characterisation of surface-modified solid lipid nanoparticles (SLN): influence of lecithin and nonionic emulsifier. Eur. J. Pharm. Biopharm. 61, 77 (2005).10.1016/j.ejpb.2005.03.006Search in Google Scholar PubMed
15. Zhou, H., Rao, J., Lin, J., Yin, B., Sheng, H., Lin, F., Zhang, N., Yang, L.: The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy. Oncol. Rep. 25, 1565 (2011).Search in Google Scholar PubMed
16. Ferretti, M., Fabbiano, C., Di Bari, M., Conte, C., Castigli, E., Sciaccaluga, M., Ponti, D., Ruggieri, P., Raco, A., Ricordy, R., Calogero, A., Tata, A. M.: M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells. J. Cell. Mol. Med. 17, 552 (2013).10.1111/jcmm.12038Search in Google Scholar PubMed
17. Martins, S., Costa-Lima, S., Carneiro, T., Cordeiro-da-Silva, A., Souto, E. B., Ferreira, D. C.: Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway. Int. J. Pharm. 430, 216 (2012).10.1016/j.ijpharm.2012.03.032Search in Google Scholar PubMed
18. Clemente, N., Ferrara, B., Gigliotti, C. L., Boggio, E., Capucchio, M. T., Biasibetti, E., Schiffer, D., Mellai, M., Annovazzi, L., Cangemi, L., Muntoni, E., Miglio, G., Dianzani, U., Battaglia, L., Dianzani, C.: Solid lipid nanoparticles carrying temozolomide for melanoma treatment. Preliminary in vitro and in vivo studies. Int. J. Mol. Sci. 19, 255 (2018).10.3390/ijms19020255Search in Google Scholar
19. Reddy, L. H., Sharma, R. K., Chuttani, K., Mishra, A. K., Murthy, R. S. R.: Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton’s lymphoma tumor bearing mice. J. Control. Release 105, 185 (2005).10.1016/j.jconrel.2005.02.028Search in Google Scholar PubMed
20. Allen, T. M., Hansen, C. B., Guo, L. S. S.: Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection. Biochim. Biophys. Acta 1150, 9 (1993).10.1016/0005-2736(93)90115-GSearch in Google Scholar PubMed
21. Khan, A., Khan, K., Imam, S. S., Aqil, M., Ahad, A., Sultana, Y., Ali, A.: Brain targeting of temozolomide via the intranasal route using lipid-based nanoparticles: brain pharmacokinetic and scintigraphic analyses. Mol. Pharm. 13, 3773 (2016).10.1021/acs.molpharmaceut.6b00586Search in Google Scholar PubMed
©2019 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Dependence of UO2 surface morphology on processing history within a single synthetic route
- Novel diamide ligands with a central carbonyl group and their comparative evaluation with the diglycolamide ligand: synthesis, extraction, DFT and chromatographic studies
- Synthesis of porous resorcinol-formaldehyde resins and study of their sorption characteristics toward Cs in highly mineralized alkaline media
- Leaching of 137Cs from Chernobyl fuel debris: corium and “lava”
- Retention behavior of anionic radionuclides using metal hydroxide sludge
- Synthesis, thermogravimetric analysis and enthalpy determination of lanthanide β-diketonates
- 99mTc(I) carbonyl-radiolabeled lipid based drug carriers for temozolomide delivery and bioevaluation by in vitro and in vivo
- FLUKA simulation yields in a comparison with theoretical and experimental yields relevant to 89Zr produced in the 89Y(p,n) reaction
- Rapid Communication
- 225Ac/213Bi generator based on inorganic sorbents
Articles in the same Issue
- Frontmatter
- Dependence of UO2 surface morphology on processing history within a single synthetic route
- Novel diamide ligands with a central carbonyl group and their comparative evaluation with the diglycolamide ligand: synthesis, extraction, DFT and chromatographic studies
- Synthesis of porous resorcinol-formaldehyde resins and study of their sorption characteristics toward Cs in highly mineralized alkaline media
- Leaching of 137Cs from Chernobyl fuel debris: corium and “lava”
- Retention behavior of anionic radionuclides using metal hydroxide sludge
- Synthesis, thermogravimetric analysis and enthalpy determination of lanthanide β-diketonates
- 99mTc(I) carbonyl-radiolabeled lipid based drug carriers for temozolomide delivery and bioevaluation by in vitro and in vivo
- FLUKA simulation yields in a comparison with theoretical and experimental yields relevant to 89Zr produced in the 89Y(p,n) reaction
- Rapid Communication
- 225Ac/213Bi generator based on inorganic sorbents
