Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene
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Uwe Königs
Abstract
A fast and efficient process for the production of the PET radionuclide 73Se was developed using 75Se as a surrogate. 75Se was separated from proton irradiated arsenic trioxide by reaction with 2,3-diaminonaphthalene to 4,5-[75Se]benzopiazelenol. This compound was purified using SPE column chromatography and subsequently decomposed with hydrogen peroxide. For further chemical conversions [75Se]selenite was reduced to elemental [75Se]selenium by either using thiosulfate or sulfur dioxide. The recovery yield of 75Se from the target amounted to 43%. The utility of the isolated 75Se for radiosyntheses was demonstrated by the successful preparation of [75Se]selenomethionine. The methodology developed using 75Se was successfully transformed to 73Se.
Acknowledgement
The authors thank B. Kolter for initial studies on the reaction of 75Se with DAN; K. Giesen and B. Scholten for their continuous support; M. Holschbach for the NMR measurements; S. Spellerberg and the cyclotron crew for the many hours of irradiation.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Adsorption behavior of U(VI) on doped polyaniline: the effects of carbonate and its complexes
- Comparison of univariate and multivariate data analysis models for uranium quantification in Trombay historical nuclear waste glass
- Efficient decontamination of naturally occurring radionuclide from aqueous carbonate solutions by ion flotation process
- Partitioning of Cs+ and Na+ ions by dibenzo-18-crown-6 ionophore in biphasic aqueous systems of octanol and ionic liquid
- Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene
- Production, quality control, biodistribution and imaging studies of 177Lu-PSMA-617 in breast adenocarcinoma model
- Assessment of rare earth elements, Th and U profile of a site for a potential coal based power plant by instrumental neutron activation analysis
- Neutron activation analysis of major and trace elements in Arabica and Robusta coffee beans samples consumed in Algeria
Artikel in diesem Heft
- Frontmatter
- Adsorption behavior of U(VI) on doped polyaniline: the effects of carbonate and its complexes
- Comparison of univariate and multivariate data analysis models for uranium quantification in Trombay historical nuclear waste glass
- Efficient decontamination of naturally occurring radionuclide from aqueous carbonate solutions by ion flotation process
- Partitioning of Cs+ and Na+ ions by dibenzo-18-crown-6 ionophore in biphasic aqueous systems of octanol and ionic liquid
- Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene
- Production, quality control, biodistribution and imaging studies of 177Lu-PSMA-617 in breast adenocarcinoma model
- Assessment of rare earth elements, Th and U profile of a site for a potential coal based power plant by instrumental neutron activation analysis
- Neutron activation analysis of major and trace elements in Arabica and Robusta coffee beans samples consumed in Algeria
