Production, quality control, biodistribution and imaging studies of 177Lu-PSMA-617 in breast adenocarcinoma model
-
Mehdi Sharifi
,
Amir Reza Jalilian
Abstract
177Lu-PSMA-617 therapeutic agent was prepared successfully under optimized condition of pH=4.5, molar ratio of metal to ligand 1:10, temperature of 95°C and 40 min reaction time. 177LuCl3 was obtained with specific activity of 70–80 GBq/mg by the thermal neutron irradiation (5×1013 n cm−2 s−1) of the enriched Lu2O3 (52% 176Lu) samples. The radionuclidic purity of 177LuCl3 (>99%) was checked by a HPGe detector. The radiochemical purities of 177LuCl3 solution and 177Lu-PSMA-617 compound (>98%) were checked by ITLC and HPLC techniques and stability studies were assayed in the presence of human serum. Biodistribution and imaging assessments in the breast adenocarcinoma-bearing mice showed a major accumulation of activity in the tumor and kidneys tissues, as the expression site of PSMA molecule and the main route of excretion, respectively.
Author’s statement: The authors declare no conflict of interest.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Adsorption behavior of U(VI) on doped polyaniline: the effects of carbonate and its complexes
- Comparison of univariate and multivariate data analysis models for uranium quantification in Trombay historical nuclear waste glass
- Efficient decontamination of naturally occurring radionuclide from aqueous carbonate solutions by ion flotation process
- Partitioning of Cs+ and Na+ ions by dibenzo-18-crown-6 ionophore in biphasic aqueous systems of octanol and ionic liquid
- Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene
- Production, quality control, biodistribution and imaging studies of 177Lu-PSMA-617 in breast adenocarcinoma model
- Assessment of rare earth elements, Th and U profile of a site for a potential coal based power plant by instrumental neutron activation analysis
- Neutron activation analysis of major and trace elements in Arabica and Robusta coffee beans samples consumed in Algeria
Articles in the same Issue
- Frontmatter
- Adsorption behavior of U(VI) on doped polyaniline: the effects of carbonate and its complexes
- Comparison of univariate and multivariate data analysis models for uranium quantification in Trombay historical nuclear waste glass
- Efficient decontamination of naturally occurring radionuclide from aqueous carbonate solutions by ion flotation process
- Partitioning of Cs+ and Na+ ions by dibenzo-18-crown-6 ionophore in biphasic aqueous systems of octanol and ionic liquid
- Isolation of high purity 73Se using solid phase extraction after selective 4,5-[73Se]benzopiazselenol formation with aminonaphthalene
- Production, quality control, biodistribution and imaging studies of 177Lu-PSMA-617 in breast adenocarcinoma model
- Assessment of rare earth elements, Th and U profile of a site for a potential coal based power plant by instrumental neutron activation analysis
- Neutron activation analysis of major and trace elements in Arabica and Robusta coffee beans samples consumed in Algeria
