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The science of genetically modified poultry

  • Mariam Ibrahim ORCID logo EMAIL logo and Katarzyna Stadnicka
Published/Copyright: January 16, 2023
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Physical Sciences Reviews
From the journal Physical Sciences Reviews Volume 9 Issue 2

Abstract

The exuberant development of targeted genome editing has revolutionized research on the chicken genome, generating chickens with beneficial parameters. The chicken model is a crucial experimental tool that can be utilized for drug manufacture, preclinical research, pathological observation, and other applications. In essence, tweaking the chicken’s genome has enabled the poultry industry to get more done with less, generating genetically modified chickens that lay eggs containing large amounts of lifesaving humanized drugs. The transition of gene editing from concept to practical application has been dramatically hastened by the development of programmable nucleases, bringing scientists closer than ever to the efficient producers of tomorrow’s medicines. Combining the developmental and physiological characteristics of the chicken with cutting-edge genome editing, the chicken furnishes a potent frontier that is foreseen to be actively pursued in the future. Herein we review the current and future prospects of gene editing in chickens and the contributions to the development of humanized pharmaceuticals.

Keywords: bioreactor; chicken; genome editing; pharmaceuticals; primordial germ cells
Corresponding author: Mariam Ibrahim, Department of Animal Biotechnology and Genetics, PBS University of Science and Technology, 85-084 Bydgoszcz, Poland, E-mail:

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-12-04
Accepted: 2022-12-07
Published Online: 2023-01-16

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/psr-2022-0352
Keywords for this article
bioreactor; chicken; genome editing; pharmaceuticals; primordial germ cells

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Topology and applications of 2D Dirac and semi-Dirac materials
  4. Landscape ecological modeling to identify ecologically significant regions in Tumkur district, Karnataka
  5. Surfactants-surface active agents behind sustainable living
  6. Ecological footprint of poultry production and effect of environment on poultry genes
  7. Fluoride in water, health implications and plant-based remediation strategies
  8. Poultry nutrition
  9. Synthesis of N-containing heterocycles in water
  10. Inorganic nanoparticles promoted synthesis of heterocycles
  11. The role of analytical chemistry in poultry science
  12. Antibiotics in avian care and husbandry-status and alternative antimicrobials
  13. Removal of heavy metals from wastewater using synthetic chelating agents
  14. Azadirachtin in the aquatic environment: Fate and effects on non-target fauna
  15. Intensification of bioprocesses with filamentous microorganisms
  16. The science of genetically modified poultry
  17. Emerging in ovo technologies in poultry production and the re-discovered chicken model in preclinical research
  18. The Cambridge structural database (CSD): important resources for teaching concepts in structural chemistry and intermolecular interactions
  19. Microbial production of lactic acid using organic wastes as low-cost substrates
  20. Oxalic acid: recent developments for cost-effective microbial production
  21. Immobilization of α-amylase from Aspergillus fumigatus using adsorption method onto zeolite
  22. A comparative assessment of potentially harmful metals in the Lagos Lagoon and Ogun river catchment
  23. Formulation of a herbal topical cream against Tinea capitis using flavonoids glycosides from Dicerocaryum senecioides and Diospyros mespiliformis
  24. Biodegradable polymers – research and applications
  25. Adsorption of trichloroacetic acid from drinking water using polyethylene terephthalate waste carbon and periwinkle shells–based chitosan
  26. The vital use of isocyanide-based multicomponent reactions (MCR) in chemical synthesis
  27. Pine bark crosslinked to cyclodextrin for the adsorption of 2-nitrophenol from an aqueous solution
  28. Computational study of propene selectivity and yield in the dehydrogenation of propane via process simulation approach
  29. A mini review on the prospects of Fagara zanthoxyloides extract based composites: a remedy for COVID-19 and associated replica?
  30. Physicochemical assessment and insilico studies on the interaction of 5-HT2c receptor with herbal medication bioactive compounds used in the treatment of premature ejaculation
  31. Horse chestnut thermoplastic starch nanocomposite films reinforced with nanocellulose
  32. Rice thermoplastic starch nanocomposite films reinforced with nanocellulose
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