Formulation of a herbal topical cream against Tinea capitis using flavonoids glycosides from Dicerocaryum senecioides and Diospyros mespiliformis
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Rudo Zhou
,
Pamhidzai Dzomba
and
Luke Gwatidzo
Abstract
Topical fungal infections including, Tinea capitis with escalating resistance to conventional therapies are a rising concern globally. Studies have shown substantial in vitro efficacy of plant compounds against fungal pathogens. This study utilized flavonoid glycosides from Dicerocaryum senecioides and Diospyros mespiliformis as active compounds to formulate a topical cream against Tinea capitis. The in vitro test utilized disc diffusion assay prepared from fungal isolates obtained from individuals showing resistance to topical miconazole. Clinical trials were performed using volunteers. Both isolated strains exhibited substantial in vitro susceptibility to the cream formulation with inhibition zones ranging between 10 and 18 mm. MIC values for both test organisms ranged between 85 mg/ml and 120 mg/ml. The cream showed stability both physico-chemically and against microbial contamination. Physicochemical parameters evaluated include colour, pH, appearance, particle size, phase separation, phase inversion, creaming, spread-ability, electrical conductivity and in vitro occlusivity test and were within the accepted range. In limited clinical trials using volunteers, Tinea capitis started disappearing as from day 5 by topically applying the cream twice per day. All the patients were completely healed by the 7th day. The results of the study showed that flavonoid glycosides from D. senecioides and D. mespiliformis are good candidates to be utilized as active natural compounds against Tinea capitis resistant strains. Therefore more clinical trials and structural elucidations are recommended.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: None declared.
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/PSR-2022-0273).
© 2023 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Reviews
- Topology and applications of 2D Dirac and semi-Dirac materials
- Landscape ecological modeling to identify ecologically significant regions in Tumkur district, Karnataka
- Surfactants-surface active agents behind sustainable living
- Ecological footprint of poultry production and effect of environment on poultry genes
- Fluoride in water, health implications and plant-based remediation strategies
- Poultry nutrition
- Synthesis of N-containing heterocycles in water
- Inorganic nanoparticles promoted synthesis of heterocycles
- The role of analytical chemistry in poultry science
- Antibiotics in avian care and husbandry-status and alternative antimicrobials
- Removal of heavy metals from wastewater using synthetic chelating agents
- Azadirachtin in the aquatic environment: Fate and effects on non-target fauna
- Intensification of bioprocesses with filamentous microorganisms
- The science of genetically modified poultry
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- Microbial production of lactic acid using organic wastes as low-cost substrates
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- A comparative assessment of potentially harmful metals in the Lagos Lagoon and Ogun river catchment
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- Computational study of propene selectivity and yield in the dehydrogenation of propane via process simulation approach
- A mini review on the prospects of Fagara zanthoxyloides extract based composites: a remedy for COVID-19 and associated replica?
- Physicochemical assessment and insilico studies on the interaction of 5-HT2c receptor with herbal medication bioactive compounds used in the treatment of premature ejaculation
- Horse chestnut thermoplastic starch nanocomposite films reinforced with nanocellulose
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