Spectral peak areas do not vary according to spectral averaging scheme used in functional MRS experiments at 3 T with interleaved visual stimulation
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Abdul Nashirudeen Mumuni
,
John McLean
Abstract
Brain response to visual stimulation can be probed quantitatively using functional magnetic resonance spectroscopy (fMRS), which relies on the blood oxygenation level dependent (BOLD) contrast mechanism. BOLD effect in fMRS is associated with changes in the areas, widths, and heights of the MR spectra. This study investigated the effect of spectral averaging scheme (NEX value) on BOLD changes in the spectra. Using a visual stimulus at 8 Hz in single and interleaved stimulation paradigms, the BOLD effects in spectra acquired from the occipital brain region of three healthy volunteers (mean age ± SD = 32.7 ± 3.5 years) were compared for two fMRS data sets acquired with two NEX values (“2” and “8”) available on a 3 T MR scanner. BOLD signal changes were estimated as percentage changes in spectral areas, heights, and widths of six cerebral metabolites and water using the SAGE software package (version 7). There was a general trend of lower BOLD effects with NEX = 8 in both stimulation paradigms. In the single stimulation paradigm, NEX = 8 was associated with significantly lower N-acetyl aspartate (NAA) spectral height (p = 0.03), creatine (p = 0.04) and choline (p = 0.02) spectral widths, and NAA (p = 0.03), water (p < 0.01), and glutamate (p = 0.02) spectral areas. In the interleaved stimulation paradigm, NEX = 8 was associated with significantly lower glutamate spectral height (p = 0.02), water (p = 0.03), and glutamine (p = 0.03) spectral widths, but there was no significant difference in all spectral areas between the two NEX values. Even though the two NEX values offered some differences in observable BOLD effects, their spectral areas were not significantly different in the interleaved visual stimulation experiments.
Funding source: University of Glasgow
Award Identifier / Grant number: 11145801
Funding source: Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE)
Award Identifier / Grant number: HR07020
Funding source: Sackler Institute of Psychological Research
Award Identifier / Grant number: 32660
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: This study was part of a larger research funded jointly at various stages by the Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE, “Scottish Funding Council HR07020”), University of Glasgow (grant number: 11145801), and Sackler Institute of Psychological Research (grant number: 32660).
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Conflict of interest statement: The authors declare no conflicts of interest regarding this article.
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Artikel in diesem Heft
- Frontmatter
- Reviews
- Modern analytical approach in biopolymer characterization
- Development of nanocellulose fiber reinforced starch biopolymer composites: a review
- Recent developments in sago starch thermoplastic bio-composites
- Mechanical degradation of sugar palm crystalline nanocellulose reinforced thermoplastic sugar palm starch (TPS)/poly (lactic acid) (PLA) blend bionanocomposites in aqueous environments
- Computational design of the novel building blocks for the metal-organic frameworks based on the organic ligand protected Cu4 cluster
- Highly functional nanocellulose-reinforced thermoplastic starch-based nanocomposites
- Spectral peak areas do not vary according to spectral averaging scheme used in functional MRS experiments at 3 T with interleaved visual stimulation
- Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica Fresen (Francoaceae)
- Immediate effects of atrazine application on soil organic carbon and selected macronutrients and amelioration by sawdust biochar pretreatment
- Process configuration of combined ozonolysis and anaerobic digestion for wastewater treatment
- Concentration levels and risk assessment of organochlorine and organophosphate pesticide residue in selected cereals and legumes sold in Anambra State, south-eastern Nigeria
- XRD and cytotoxicity assay of submitted nanomaterial industrial samples in the Philippines
- Comparative study of the photocatalytic degradation of tetracycline under visible light irradiation using Bi24O31Br11-anchored carbonaceous and silicates catalyst support
- Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer
- Barley thermoplastic starch nanocomposite films reinforced with nanocellulose
- Integration of chemo- and bio-catalysis to intensify bioprocesses
- Fabrication of starch-based packaging materials
- Potato thermoplastic starch nanocomposite films reinforced with nanocellulose
- Review on sago thermoplastic starch composite films reinforced with nanocellulose
- Wheat thermoplastic starch composite films reinforced with nanocellulose
- Synergistic effect in bimetallic gold catalysts: recent trends and prospects
- Simultaneous removal of methylene blue, copper Cu(II), and cadmium Cd(II) from synthetic wastewater using fennel-based adsorbents
- The investigation of the physical properties of an electrical porcelain insulator manufactured from locally sourced materials
- Concentration evaluation and risk assessment of pesticide residues in selected vegetables sold in major markets of Port Harcourt South-South Nigeria
- Detection of iodine in aqueous extract of plants through modified Mohr’s method
- Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management
- A new sphingoid derivative from Acacia hockii De Wild (Fabaceae) with antimicrobial and insecticidal properties
- Protection of wood against bio-attack and research of new effective and environmental friendly fungicides
- Computational investigation of Arbutus serratifolia Salisb molecules as new potential SARS-CoV-2 inhibitors
- Exploring the solvation of water molecules around radioactive elements in nuclear waste water treatment
Artikel in diesem Heft
- Frontmatter
- Reviews
- Modern analytical approach in biopolymer characterization
- Development of nanocellulose fiber reinforced starch biopolymer composites: a review
- Recent developments in sago starch thermoplastic bio-composites
- Mechanical degradation of sugar palm crystalline nanocellulose reinforced thermoplastic sugar palm starch (TPS)/poly (lactic acid) (PLA) blend bionanocomposites in aqueous environments
- Computational design of the novel building blocks for the metal-organic frameworks based on the organic ligand protected Cu4 cluster
- Highly functional nanocellulose-reinforced thermoplastic starch-based nanocomposites
- Spectral peak areas do not vary according to spectral averaging scheme used in functional MRS experiments at 3 T with interleaved visual stimulation
- Triterpenoids of antibacterial extracts from the leaves of Bersama abyssinica Fresen (Francoaceae)
- Immediate effects of atrazine application on soil organic carbon and selected macronutrients and amelioration by sawdust biochar pretreatment
- Process configuration of combined ozonolysis and anaerobic digestion for wastewater treatment
- Concentration levels and risk assessment of organochlorine and organophosphate pesticide residue in selected cereals and legumes sold in Anambra State, south-eastern Nigeria
- XRD and cytotoxicity assay of submitted nanomaterial industrial samples in the Philippines
- Comparative study of the photocatalytic degradation of tetracycline under visible light irradiation using Bi24O31Br11-anchored carbonaceous and silicates catalyst support
- Xanthoangelol, geranilated chalcone compound, isolation from pudau leaves (Artocarpus kemando Miq.) as antibacterial and anticancer
- Barley thermoplastic starch nanocomposite films reinforced with nanocellulose
- Integration of chemo- and bio-catalysis to intensify bioprocesses
- Fabrication of starch-based packaging materials
- Potato thermoplastic starch nanocomposite films reinforced with nanocellulose
- Review on sago thermoplastic starch composite films reinforced with nanocellulose
- Wheat thermoplastic starch composite films reinforced with nanocellulose
- Synergistic effect in bimetallic gold catalysts: recent trends and prospects
- Simultaneous removal of methylene blue, copper Cu(II), and cadmium Cd(II) from synthetic wastewater using fennel-based adsorbents
- The investigation of the physical properties of an electrical porcelain insulator manufactured from locally sourced materials
- Concentration evaluation and risk assessment of pesticide residues in selected vegetables sold in major markets of Port Harcourt South-South Nigeria
- Detection of iodine in aqueous extract of plants through modified Mohr’s method
- Exploration of bioactive compounds from Mangifera indica (Mango) as probable inhibitors of thymidylate synthase and nuclear factor kappa-B (NF-Κb) in colorectal cancer management
- A new sphingoid derivative from Acacia hockii De Wild (Fabaceae) with antimicrobial and insecticidal properties
- Protection of wood against bio-attack and research of new effective and environmental friendly fungicides
- Computational investigation of Arbutus serratifolia Salisb molecules as new potential SARS-CoV-2 inhibitors
- Exploring the solvation of water molecules around radioactive elements in nuclear waste water treatment
