Electrosprayed low toxicity polycaprolactone microspheres from low concentration solutions
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Sharifah Nabihah Syed Jaafar
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Izzah Farhah Zambari
Abstract
This work describes the successful tunable production of polycaprolactone (PCL) microspheres using very low-concentration solutions. The PCL solutions (1, 3, and 5 w/v%) were prepared with different solvents (dichloromethane (DCM) and chloroform (CHL)) and electrosprayed at different distances (5, 10, and 15 cm). The solubility and viscosity of PCL solutions were in accordance with the polymer concentrations, demonstrating PCL-DCM gave a higher solubility of PCL, but PCL-CHL solutions had a higher viscosity. Optical microscopy (OM) and field emission-scanning electron microscopy (FE-SEM) revealed that the PCL-DCM preparations produced a smaller and more uniform microsphere size and pore size compared to PCL-CHL microspheres. The linear regression analysis showed that the solubility and viscosity of PCL concentration influence the size of microspheres more greatly than the pore size. The toxicity results indicated that PCL-CHL and PCL-DCM are well-tolerated by zebrafish embryos that were able to follow a normal growth pathway and can thus be deemed safe.
Funding source: Geran Universiti Penyelidikan
Award Identifier / Grant number: GUP-2017-114
Award Identifier / Grant number: GUP-2021-041
Acknowledgments
The authors would like to acknowledge Prof. Mohd Firdaus Mohd Raih and the Bioresource & Biorefinery Laboratory for the technical and infrastructural support.
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Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
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Research funding: The authors would like to acknowledge the Universiti Kebangsaan Malaysia for funding (grants GUP-2021-041 and GUP-2017-114).
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Conflict of interest statement: The authors declare that they have no conflicts of interest regarding this article.
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Research ethics: The Universiti Putra Malaysia’s Institutional Animal Care and Use Committee (IACUC) has approved this in vivo study (UPM/IACUC/AUP-R044/2022), which was conducted in compliance with said committee’s regulations.
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Artikel in diesem Heft
- Frontmatter
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- Structural characters of biaxially stretched polypropylene films and the relevant electrical insulating properties
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- The consequences of removing fluorinated compounds from rigid contact lenses
- Electrosprayed low toxicity polycaprolactone microspheres from low concentration solutions
- Engineering and Processing
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Artikel in diesem Heft
- Frontmatter
- Material Properties
- A fundamental approach to determine the impact of aramid and carbon fibers on durability and tribological performance of different polymer composites demonstrated in gear transmission process
- Structural characters of biaxially stretched polypropylene films and the relevant electrical insulating properties
- Preparation and Assembly
- The consequences of removing fluorinated compounds from rigid contact lenses
- Electrosprayed low toxicity polycaprolactone microspheres from low concentration solutions
- Engineering and Processing
- Molecular dynamics simulation of stretch-induced crystallization of star polymers as compared to their linear counterparts
- Additive manufactured parts produced by selective laser sintering technology: porosity formation mechanisms
- The efficient removal of low concentration hexavalent chromium via combining charged microporous membrane and micellar adsorption filtration
