Ionic gelated β-cyclodextrin-biotin-carboxymethyl chitosan nanoparticles prepared as carrier for oral delivery of protein drugs
-
Kuanmin Chen
and
Renmin Gong
Abstract
In this paper, the β-cyclodextrin (β-CD) and biotin (Bi) were successfully grafted onto carboxymethyl chitosan (CMCS). And then the β-CD-Bi-CMCS nanoparticles (NPs) were prepared as oral nano-delivery carrier of protein drugs by ionic gelation method. The morphological feature of fabricated drug carrier was determined by dynamic light scattering and transmission electron microscopy. The result showed that the prepared NPs presented spherical structure with an average diameter of 138 nm. Bovine serum albumin (BSA) was selected as model protein drug that was entrapped in prepared drug carrier with satisfactory entrapment efficiency (79.18%) and loading content (3.96%). The drug release profiles of BSA/β-CD-Bi-CMCS NPs were studied at different pH environment for simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). It was found that the BSA/β-CD-Bi-CMCS NPs displayed a pH dependent drug release profiles. After 72 h, the cumulative release amount of BSA in SGF, SIF, and SCF was about 20.57, 74.46, and 91%, respectively. Furthermore, the enzymatic degradation and cytotoxicity studies showed the synthesized β-CD-Bi-CMCS NPs had high chemical stability and biocompatibility. This work indicated that the β-CD-Bi-CMCS NPs had the potentiality as promising nanocarriers for oral delivery of protein drugs.
Funding source: The Innovation Team of Scientific Research Platform in Anhui Universities
Funding source: The Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, Anhui Normal University
Funding source: The Key Laboratory of Bioresource Protection and Utilization of Anhui Province
Funding source: The Key Laboratory of Biotic Environment and Ecological Safety of Anhui Province
Research funding: This work was financially supported by the Innovation Team of Scientific Research Platform in Anhui Universities, the Key Laboratory of Bioresource Protection and Utilization of Anhui Province, the Key Laboratory of Biotic Environment and Ecological Safety of Anhui Province, and the Key Laboratory of Biomedicine in Gene Diseases and Health of Anhui Higher Education Institutes, Anhui Normal University.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
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- Ionic gelated β-cyclodextrin-biotin-carboxymethyl chitosan nanoparticles prepared as carrier for oral delivery of protein drugs
Articles in the same Issue
- Frontmatter
- Material properties
- Structure-properties relationship for energy storage redox polymers: a review
- Effects of chain polarity of hindered phenol on the damping properties of polymer-based hybrid materials: insights into the molecular mechanism
- Effect of interfacial modification on the thermo-mechanical properties of flax reinforced polylactide stereocomplex composites
- Use of diisocyanate to enhance the flame-retardant, mechanical and crystalline properties of poly (butylene succinate-co-butylene 3-hydroxyphenylphosphinyl-propionate) (PBSH)
- Preparation and assembly
- Graphene oxide modified carbon fiber reinforced epoxy composites
- Fabrication and evaluation of polylactic acid/pectin composite scaffold via freeze extraction for tissue engineering
- Engineering and processing
- Study on the interface morphology in the induction welding joint of PEEK plate at low power
- Ionic gelated β-cyclodextrin-biotin-carboxymethyl chitosan nanoparticles prepared as carrier for oral delivery of protein drugs
