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Study on synthesizing the complex of sorafenib with 2-hydroxypropyl-β-cyclodextrin to enhance the anticancer activity of the drug substance

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Published/Copyright: March 25, 2024
Pure and Applied Chemistry
From the journal Pure and Applied Chemistry Volume 96 Issue 8

Abstract

This study aims to synthesize inclusion complex derived from sorafenib (Sor) and hydroxypropyl-β-cyclodextrin (HPβCD) (denoted as [Sor-HPβCD]). The complex of Sor with HPβCD has been synthesized in a mixed solvent of H2O-DMSO, with a DMSO volume fraction of 80 %. The results of FTIR, DSC, and UV–Vis analysis have demonstrated the success of complex formation: the intensity of some characteristic peaks for the Sor binding decreased after complex formation, indicating that a part of the guest molecule has entered the cavity of the HPβCD molecule. This is further supported by the DSC analysis results, showing the transformation of the complex’s crystalline form to an amorphous form. The phase solubility diagram study also indicates that the solubility of Sor significantly increases, approximately 7 times higher than pure Sor, after complex formation. The results of the cell growth inhibition activity test in a water environment show that the complex inhibits the growth of Hep-G2 cells with an IC50 value of 62.4 μg/mL, while pure Sor does not exhibit activity as it is practically insoluble in water.

Keywords: Advanced materials for environmental protection; anti-cancer; cyclodextrin; drug carrier; inclusion complex; solubility; sorafenib
Corresponding author: Pham Thi Lan, Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam; and Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam, e-mail:
Article note: A collection of invited papers on the advanced materials for environmental protection.

Funding source: Vietnam Academy of Science and Technology

Award Identifier / Grant number: THTETN.07/22-24

  1. Research funding: This research was funded by Vietnam Academy of Science and Technology (VAST) in the project with grant number: THTETN.07/22-24.

References

[1] H. S. Tuli, V. K. Gara, S. Bhushan, V. Uttam, U. Sharma, A. Jain. Transl. Oncol. 27, 101596 (2023), https://doi.org/10.1016/j.tranon.2022.101596, https://pubmed.ncbi.nlm.nih.gov/?term=Sak+K&cauthor_id=36473401.Search in Google Scholar PubMed PubMed Central

[2] K. P. Yeshi, P. Yangdon, S. Khashyap, P. Wangchuk. J. Biol. Act. Products Nat. 7(1), 18–26 (2017), https://doi.org/10.1080/22311866.2017.1287593.Search in Google Scholar

[3] S. M. Wilhelm, L. Adnane, P. Newell, A. Villanueva, J. M. Lloovet, M. Lynch. Mol. Cancer Ther. 7, 3129–3140 (2008), https://doi.org/10.1158/1535-7163.mct-08-0013.Search in Google Scholar

[4] R. C. P. Alves, D. Alves, B. Guz, C. Matos, M Viana, M. Harriz, D. Terrabuio, M. Kondo, O. Gampel. Ann. Hepatol. 10(1), 21–27 (2016).Search in Google Scholar

[5] Y. Zhang, D. Xu, X. Wang, M. Lu, B. Gao, X. Qiao. Mol. Med. Rep. 9(1), 83–90 (2014), https://doi.org/10.3892/mmr.2013.1781.Search in Google Scholar PubMed

[6] O. Rosmorduc, C. Desbois-Mouthon. J. Hepatol. 55(5), 957–959 (2011), https://doi.org/10.1016/j.jhep.2011.06.005.Search in Google Scholar PubMed

[7] M. M. Doherty, K. S. Pang. Drug Chem. Toxicol. 20(4), 329–344 (2008), https://doi.org/10.3109/01480549709003891.Search in Google Scholar PubMed

[8] L. Wang, M. Chen, X. Ran, H. Tang, D. Cao. Polymer 15, 2638 (2023), https://doi.org/10.3390/polym15122638.Search in Google Scholar PubMed PubMed Central

[9] M. A. Khan, A. Raza, M. Ovais, M. F. Sohail, A. Raza. Int. J. Pharm. 67, 1–11 (2018).10.1080/00914037.2018.1429434Search in Google Scholar

[10] A. Bartos, I. Iancu, L. Ciobanu, A. Onaciu, C. Moldovan, A. Moldovan. Nanomaterials 12, 2833 (2022), https://doi.org/10.3390/nano12162833.Search in Google Scholar PubMed PubMed Central

[11] R. Challa, A. Ahuja, J. Ali, R. K. Khar. AAPS PharmSciTech 6(2), E329–E357 (2005), https://doi.org/10.1208/pt060243.Search in Google Scholar PubMed PubMed Central

[12] J. Li, X. J. Loh. Adv. Drug Delivery Rev. 60(9), 1000–1017 (2008), https://doi.org/10.1016/j.addr.2008.02.011.Search in Google Scholar PubMed

[13] L. Wang, D. Wu, J. Chen, J. Wu. Food Chem. 141(3), 3072–3076 (2013), https://doi.org/10.1016/j.foodchem.2013.05.149.Search in Google Scholar PubMed

[14] B. Tian, D. Xiao, T. Hei, R. Ping, S. Hua, J. Liu. Polymer 69, 597–603 (2020), https://doi.org/10.1002/pi.5992.Search in Google Scholar

[15] T. Higuchi. Adv. Anal. Chem. Instrum. 4, 117–212 (1965).Search in Google Scholar

[16] A. Waugh, A. Grant. Anatomy and Physiology in Health and Illness, Churchill Livingstone Elsevier, Philadelphia, PA, USA, 10th ed. (2007).Search in Google Scholar

[17] K. Likhitayawuid, C. K. Angerhofer. J. Nat. Products 56(1) 30–38 (1993).10.1021/np50091a005Search in Google Scholar PubMed

[18] B. Cheirsilp, J. Rakmai. Biol. Eng. Med. 2, 1000108 (2016).10.15761/BEM.1000108Search in Google Scholar

[19] T. R. Usacheva, T. L. Pham, T. D. Nguyen, D. Kabirov, D. Alister, X. M. Vu, T. M. H. Le, V. Sharnin, C. Giancola. J. Thermal Anal. Calorimetry 142, 2015–2024 (2020), https://doi.org/10.1007/s10973-020-09807-4.Search in Google Scholar

[20] A. Aman, S. Ali, P. Mahalapbutr, K. Krusong, P. Wolschann, T. Rungrotmongkol. RSC Adv. 13, 27244–27254 (2023), https://doi.org/10.1039/d3ra03867j.Search in Google Scholar PubMed PubMed Central

[21] M. V. Papezhuk, V. A. Volynkin, T. A. Stroganova, G. D. Krapivin, T. R. Usacheva, T. L. Pham. Macroheterocycles 13, 64–73 (2020), https://doi.org/10.6060/mhc191281v.Search in Google Scholar

[22] T. L. Pham, X. M. Vu, H. K. Le, D. N. Kabirov, T. N. Nguyen, T. R. Usacheva. Russian J. Phys. Chem. 95(5), 887–893 (2021).10.1134/S0036024421050113Search in Google Scholar

[23] M. L. Bondì, A. Scala, G. Sortino, E. Amore, C. Botto, A. Azzolina. Biomacromolecules 16, 3784–3791 (2015), https://doi.org/10.1021/acs.biomac.5b01082.Search in Google Scholar PubMed

[24] F. Laneri, A. C. E. Graziano, M. Seggio, A Fraix, M. Malanga, S. Béni. G. Longobardi, C. Conte, F. Quaglia, S. Sortino. Molecules 27, 1918 (2022), https://doi.org/10.3390/molecules27061918.Search in Google Scholar PubMed PubMed Central

Published Online: 2024-03-25
Published in Print: 2024-08-27

© 2024 IUPAC & De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Preface
  4. Special issue on “Advanced materials for environmental protection and sustainability in Asean countries”
  5. Special topic papers
  6. Nanocomposite nanofibrous membranes of graphene and graphene oxide: water remediation potential
  7. Selection of graphene as a conductive additive for biomass-based activated carbon electrode in capacitive deionization: acid-treated as a practical approach to reduce graphene content
  8. Biochar-based catalysts: a potential disposal of plant biomass from phytoremediation
  9. Bio-based aerogel composites of coconut pith-derived carbon and chitosan for efficient anionic dye-polluted water treatment
  10. Study on synthesizing the complex of sorafenib with 2-hydroxypropyl-β-cyclodextrin to enhance the anticancer activity of the drug substance
  11. An antimicrobial acrylic polyurethane coating with TiO2-Ag hybrid nanoparticles
  12. Efficient synthesis of tricaproin: catalyst and reaction optimization
  13. Enhanced photocatalytic and antibacterial properties of silver–zirconia nanoparticles for environmental pollution treatment
  14. Preparation of sulfur nanoparticles in chitosan-copper complex and investigation of its nematicidal activity against Pratylenchus pratensis in vitro
  15. Fabrication of cathode electrodes based on activated carbon, reduced-graphene for hybrid capacitive deionization technology
  16. Biodegradable thermochromic polylactic acid (PLA) sensor
  17. Effect of ground tyre rubber content on self-healing properties of natural rubber composites
  18. Preparation of composite based on MXene-Ti3C2 and coconutshell-derived activated carbon for desalination of brackish water
  19. Producing an antibacterial acrylic polyurethane coating with acylated mimosa tannins
  20. Effect of multi-walled carbon nanotubes reinforcement on self-healing performance of natural rubber
  21. Mechanical properties of web kapok/fiberglass-epoxy hybrid composites for marine structures
  22. Investigation on recycling and reprocessing ability of self-healing natural rubber based on ionic crosslink network
https://doi.org/10.1515/pac-2024-0024
Keywords for this article
Advanced materials for environmental protection; anti-cancer; cyclodextrin; drug carrier; inclusion complex; solubility; sorafenib

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Preface
  4. Special issue on “Advanced materials for environmental protection and sustainability in Asean countries”
  5. Special topic papers
  6. Nanocomposite nanofibrous membranes of graphene and graphene oxide: water remediation potential
  7. Selection of graphene as a conductive additive for biomass-based activated carbon electrode in capacitive deionization: acid-treated as a practical approach to reduce graphene content
  8. Biochar-based catalysts: a potential disposal of plant biomass from phytoremediation
  9. Bio-based aerogel composites of coconut pith-derived carbon and chitosan for efficient anionic dye-polluted water treatment
  10. Study on synthesizing the complex of sorafenib with 2-hydroxypropyl-β-cyclodextrin to enhance the anticancer activity of the drug substance
  11. An antimicrobial acrylic polyurethane coating with TiO2-Ag hybrid nanoparticles
  12. Efficient synthesis of tricaproin: catalyst and reaction optimization
  13. Enhanced photocatalytic and antibacterial properties of silver–zirconia nanoparticles for environmental pollution treatment
  14. Preparation of sulfur nanoparticles in chitosan-copper complex and investigation of its nematicidal activity against Pratylenchus pratensis in vitro
  15. Fabrication of cathode electrodes based on activated carbon, reduced-graphene for hybrid capacitive deionization technology
  16. Biodegradable thermochromic polylactic acid (PLA) sensor
  17. Effect of ground tyre rubber content on self-healing properties of natural rubber composites
  18. Preparation of composite based on MXene-Ti3C2 and coconutshell-derived activated carbon for desalination of brackish water
  19. Producing an antibacterial acrylic polyurethane coating with acylated mimosa tannins
  20. Effect of multi-walled carbon nanotubes reinforcement on self-healing performance of natural rubber
  21. Mechanical properties of web kapok/fiberglass-epoxy hybrid composites for marine structures
  22. Investigation on recycling and reprocessing ability of self-healing natural rubber based on ionic crosslink network
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