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Efficient synthesis of tricaproin: catalyst and reaction optimization

  • Lenar I. Musin EMAIL logo , Renat M. Akhmadullin , Karim R. Gizutdinov , Lilya Sh. Nigmatullina , Leonid V. Lopukhov , Anna N. Zaripova , Dinar D. Nigamatullin , Valerii V. Spiryagin , Huu Quynh Anh Le ORCID logo EMAIL logo , Thi Nam Pham , My Uyen Dao EMAIL logo , Hong Dung Lai and Hien Y Hoang EMAIL logo
Published/Copyright: March 29, 2024
Pure and Applied Chemistry
From the journal Pure and Applied Chemistry Volume 96 Issue 8

Abstract

This study presents a short communication on exploring, for the first time, a simple approach for the selective and highly effective synthesis of tricaproin by synergistically combining silicon tripolyphosphate and phosphoric acid in the catalytic esterification of glycerol with caproic acid. Results reveal that within the initial hour of the synthesis, the conversion in the presence of the proposed mixture achieved an efficiency of 62.99 %, whereas this figure for individual catalysts only modestly stopped at 27.50 and 11.74 %, respectively. Furthermore, the inherent shortcomings in the tricaprion synthesis, such as catalyst deactivation, resinification of the reaction solution, and generation of numerous by-products, were successfully addressed. The structure of the resultant tricaproin and the possible absence of undesired by-products were confirmed by NMR, mass spectrometry, FT-IR, and TLC. The optimal conditions for the synthesis were also investigated. The study not only contributes a practical and selective synthetic approach for tricaproin but also paves the way for exploring novel avenues to enhance the efficiency of the catalytic esterification.

Keywords: Advanced materials for environmental protection; catalytic esterification; phosphoric acid; silicon tripolyphosphate; tricaproin
Corresponding authors: Lenar I. Musin, LLC R&D Center “AhmadullinS”, Sibirskii trakt street 34, Building 10, Kazan, 420029, Russia, e-mail: ; Huu Quynh Anh Le, Ho Chi Minh City University of Natural Resources and Environment, Ho Chi Minh City, Vietnam, e-mail: ; and My Uyen Dao and Hien Y Hoang, Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, Da Nang, 550000, Vietnam; and Faculty of Environmental and Chemical Engineering, Duy Tan University, Danang, 550000, Vietnam, e-mail: (U. M. Dao), (H. Y. Hoang)
Article note: A collection of invited papers on the advanced materials for environmental protection.

  1. Research funding: There is no funding for this study.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/pac-2024-0017).

Published Online: 2024-03-29
Published in Print: 2024-08-27

© 2024 IUPAC & De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Preface
  4. Special issue on “Advanced materials for environmental protection and sustainability in Asean countries”
  5. Special topic papers
  6. Nanocomposite nanofibrous membranes of graphene and graphene oxide: water remediation potential
  7. Selection of graphene as a conductive additive for biomass-based activated carbon electrode in capacitive deionization: acid-treated as a practical approach to reduce graphene content
  8. Biochar-based catalysts: a potential disposal of plant biomass from phytoremediation
  9. Bio-based aerogel composites of coconut pith-derived carbon and chitosan for efficient anionic dye-polluted water treatment
  10. Study on synthesizing the complex of sorafenib with 2-hydroxypropyl-β-cyclodextrin to enhance the anticancer activity of the drug substance
  11. An antimicrobial acrylic polyurethane coating with TiO2-Ag hybrid nanoparticles
  12. Efficient synthesis of tricaproin: catalyst and reaction optimization
  13. Enhanced photocatalytic and antibacterial properties of silver–zirconia nanoparticles for environmental pollution treatment
  14. Preparation of sulfur nanoparticles in chitosan-copper complex and investigation of its nematicidal activity against Pratylenchus pratensis in vitro
  15. Fabrication of cathode electrodes based on activated carbon, reduced-graphene for hybrid capacitive deionization technology
  16. Biodegradable thermochromic polylactic acid (PLA) sensor
  17. Effect of ground tyre rubber content on self-healing properties of natural rubber composites
  18. Preparation of composite based on MXene-Ti3C2 and coconutshell-derived activated carbon for desalination of brackish water
  19. Producing an antibacterial acrylic polyurethane coating with acylated mimosa tannins
  20. Effect of multi-walled carbon nanotubes reinforcement on self-healing performance of natural rubber
  21. Mechanical properties of web kapok/fiberglass-epoxy hybrid composites for marine structures
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https://doi.org/10.1515/pac-2024-0017
Keywords for this article
Advanced materials for environmental protection; catalytic esterification; phosphoric acid; silicon tripolyphosphate; tricaproin

Articles in the same Issue

  1. Frontmatter
  2. In this issue
  3. Preface
  4. Special issue on “Advanced materials for environmental protection and sustainability in Asean countries”
  5. Special topic papers
  6. Nanocomposite nanofibrous membranes of graphene and graphene oxide: water remediation potential
  7. Selection of graphene as a conductive additive for biomass-based activated carbon electrode in capacitive deionization: acid-treated as a practical approach to reduce graphene content
  8. Biochar-based catalysts: a potential disposal of plant biomass from phytoremediation
  9. Bio-based aerogel composites of coconut pith-derived carbon and chitosan for efficient anionic dye-polluted water treatment
  10. Study on synthesizing the complex of sorafenib with 2-hydroxypropyl-β-cyclodextrin to enhance the anticancer activity of the drug substance
  11. An antimicrobial acrylic polyurethane coating with TiO2-Ag hybrid nanoparticles
  12. Efficient synthesis of tricaproin: catalyst and reaction optimization
  13. Enhanced photocatalytic and antibacterial properties of silver–zirconia nanoparticles for environmental pollution treatment
  14. Preparation of sulfur nanoparticles in chitosan-copper complex and investigation of its nematicidal activity against Pratylenchus pratensis in vitro
  15. Fabrication of cathode electrodes based on activated carbon, reduced-graphene for hybrid capacitive deionization technology
  16. Biodegradable thermochromic polylactic acid (PLA) sensor
  17. Effect of ground tyre rubber content on self-healing properties of natural rubber composites
  18. Preparation of composite based on MXene-Ti3C2 and coconutshell-derived activated carbon for desalination of brackish water
  19. Producing an antibacterial acrylic polyurethane coating with acylated mimosa tannins
  20. Effect of multi-walled carbon nanotubes reinforcement on self-healing performance of natural rubber
  21. Mechanical properties of web kapok/fiberglass-epoxy hybrid composites for marine structures
  22. Investigation on recycling and reprocessing ability of self-healing natural rubber based on ionic crosslink network
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