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Disinfecting activity of some diphenyltin(IV) benzoate derivative compounds

  • Sutopo Hadi EMAIL logo , Tati Suhartati , Noviany Noviany , Kamisah D. Pandiangan , Yandri Yandri , Wasinton Simanjuntak and Junaidi Junaidi
Published/Copyright: March 17, 2022

Abstract

Disinfecting activity test of four diphenyltin(IV) benzoate derivative compounds has been carried out. The four compounds investigated were diphenyltin (IV) di 4 aminobenzoate (DPDA) (2), diphenyltin (IV) di 4 chlorobenzoate (DPDC) (3), diphenyltin(IV) di-4-hydroxybenzoate (DPDH) (4), and diphenyltin(IV) di-4-nitrobenzoate (DPDN) (5), and they were prepared by reacting diphenyltin(IV) oxide (DPO) (1) with benzoic acid derivatives of 4-aminobenzoic acid (4-HABz), 4-chlorobenzoic acid (4-HCBz), 4-hydroxybenzoic acid (4-HHBz) and 4-nitrobenzoic acid (4-HNBz), respectively. The compounds were well characterized by 1H, 13C NMR, IR, UV spectroscopies, and their pieces were defined using microanalytical data. The disinfectant test was carried out on two bacteria, Gram-negative Salmonella sp., and Gram-positive Staphylococus aureus. The result showed that all of the compounds were active as a disinfectant (disinfecting agent) with a minimum inhibitory concentration of 5 × 10−4 M. Compound 5 was found to be most active compared to others which exhibited the ability to reduce the concentration of the S. aureus bacteria within 5 min.


Article note:

A collection of invited papers based on presentations at the Virtual Conference on Chemistry and its Applications (VCCA-2021) held on-line, 9–13 August 2021.



Corresponding author: Sutopo Hadi, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Lampung, Bandar Lampung 35145, Indonesia, E-mail:

Acknowledgments

We would like to thank some people who have to help us in the experimental part, including our students Anggit A. Putri, Dini Aulia, Ahmad Farisi, Olivia Margareta, and also Liza Aprilia and Tri Kiswantari for their help and for allowing us to use some spaces in the laboratory.

  1. Research funding: The authors’ gratitude to the Institute of Research and Community Services, Universitas Lampung as well as Directorate of Research and Community Services, The Ministry of Education, Cultural. Research and Technology, Indonesia that gave access to funding the assignment carried out through Penelitian Dasar (Basic Research Grant Scheme) 2021 with Agreement Numbers of 120/E4.1/AK.04.PT/2021 and 3972/UN26.21/PN/2021.

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Published Online: 2022-03-17
Published in Print: 2022-07-26

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