Androgens and cardiovascular risk1)
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Elisabeth Lerchbaum
Abstract
Testosterone concentrations in men gradually decrease with age. Whether this reduction in androgen levels is a pathological process or a physiological event remains to be determined. The age-related decrease in testosterone levels is, however, frequently accompanied by adverse health consequences including low bone and muscle mass, increased fat mass, type 2 diabetes mellitus and the metabolic syndrome. Moreover, low androgen levels are associated with increased mortality. Testosterone treatment should be performed in men with low androgen levels as well as clinical signs and symptoms of hypogonadism. In premenopausal women, hyperandrogenemia is associated with several cardiovascular risk factors. The most common cause of hyperandrogenemia in women is polycystic ovary syndrome (PCOS). PCOS women are affected by hyperandrogenism, infertility and metabolic disturbances, such as insulin resistance, central obesity and dyslipidemia. Androgen levels decrease with menopausal transition in women. Hyperandrogenemia is associated with insulin resistance and type 2 diabetes in postmenopausal women. Whether this hyperandrogenemia results in increased mortality is, however, less clear. Moreover, the impact of androgen supplementation in postmenopausal women with hypoandrogenemia is open.
©2012 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Infektiologie und Mikrobiologie (Schwerpunkt Bakteriologie)/Infectiology and Microbiology (Focus Bacteriology)
- Diagnostik invasiver Pilzinfektionen/Diagnosis of invasive fungal infections
- Blutkulturdiagnostik – Standards und aktuelle Entwicklungen/Blood culture diagnostics: standards and recent developments
- Blood culture diagnostics – standards and recent developments1)
- Fallbericht Meningokokken-Meningitis/Meningococcal meningitis: a case study
- Klinische Chemie und Stoffwechsel/Clinical Chemistry and Metabolism
- Cystatin C – ein endogener Nierenfunktions- und Prognosemarker/Cystatin C: an endogenous GFR marker and prognosis factor
- Cystatin C – an endogenous GFR marker and prognosis factor1)
- Androgene und kardiovaskuläres Risiko/Androgens and cardiovascular risk
- Androgens and cardiovascular risk1)
- Molekulargenetische und Zytogenetische Diagnostik/Molecular-Genetic and Cytogenetic Diagnostics
- Diagnostic applications of next generation sequencing: working towards quality standards/Diagnostische Anwendung von Next Generation Sequencing: Auf dem Weg zu Qualitätsstandards
- Bericht zur 11. Jahrestagung der Sektion Molekulare Diagnostik der DGKL
- Report on the 11th Annual Meeting of the Section of Molecular Diagnostics of DGKL1)
- Buchbesprechung/Book Reviews
- Immunodiagnostics and Patient Safety
- Ascites Hyponatriemia and Hepatorenal Syndrome
- Erratum
- Point-of-Care Testing
- Effektive Glykolyse-Inhibierung im Citrat-gepufferten venösen Vollblut und Plasma/Effective inhibition of glycolysis in venous whole blood and plasma samples
