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Colonization, serotypes and transmission rates of group B streptococci in pregnant women and their infants born at a single University Center in Germany
-
Mirjam Kunze
,
Anna Ziegler
Veröffentlicht/Copyright:
10. Mai 2011
Abstract
Objective: To evaluate colonization, transmission rate and serotype distribution of group B streptococci (GBS) in pregnant women and infants born in a single University Center in Germany.
Methods: In a prospective study we collected cultures from pregnant women and ear cultures from newborns. We performed serotyping and susceptibility testing. Obstetrical factors associated with mother to infant transmission were analyzed using logistic regression.
Results: We evaluated cultures of 869 pregnant women and 845 neonates including 657 paired maternal-neonatal cultures. Maternal colonization occurred in 21.1% (183/869), transmission from mother to newborn in 11.2% (17/152). Intrapartum antimicrobial prophylaxis (IAP) and cesarean delivery were associated with reduction of transmission rate (P=0.014 and 0.019, respectively). The incidence for early-onset disease (EOD) was 1.71 per 1000 live births. Of GBS positive women IAP was administered in only 39% (59/152). Serotype III was the most prevalent isolate (28% maternal; 52% neonatal) and transmission occurred more frequently compared to other serotypes.
Conclusions: The incidence of EOD and distribution of serotypes in Germany are similar to published data from the USA prior to 1996. Despite national guidelines with universal GBS screening, our study demonstrated a lack of adherence to this recommendation. There is a need for enhanced compliance.
Keywords: Colonization; early-onset GBS disease; group B streptococci; intrapartum prophylaxis; serotypes; transmission
Received: 2010-6-11
Revised: 2011-1-6
Accepted: 2011-2-4
Published Online: 2011-05-10
Published Online: 2011-05-11
Published in Print: 2011-07-01
©2011 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
Colonization;
early-onset GBS disease;
group B streptococci;
intrapartum prophylaxis;
serotypes;
transmission
Artikel in diesem Heft
- Review articles
- Bridging global gene expression candidates in first trimester placentas with susceptibility loci from linkage studies of preeclampsia
- Candidates for the determination of antithrombin activity in pregnant women
- Opinion paper
- Using prophylactic, but not tocolytic, magnesium sulfate to reduce cerebral palsy related to prematurity: what dose, and what about infant mortality?
- Original articles – Obstetrics
- Vaginal breech delivery in very low birth weight (VLBW) neonates: experience of a single center
- Fetal outcome for infants in breech by method of delivery: experiences with a stand-by service system of senior obstetricians and women's choices of mode of delivery
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- Expression of laminin receptor 1 in human placentas from normal and preeclamptic pregnancies and its relationship with the severity of preeclampsia
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- The placental factor in spontaneous preterm labor with and without premature rupture of membranes
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- Original articles – Newborn
- Ductus venosus flow at 11–13 weeks in the prediction of birth weight discordance in monochorionic twins
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- Short communication
- Supracervical cerclage with intracavitary balloon to control bleeding associated with placenta previa
- Letter to the Editor
- Two cases of Lowe syndrome presenting as increased fetal nuchal translucency
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- Congress Calendar
