Clinical significance of oligohydramnios in patients with preterm labor and intact membranes*,**
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Byoung Jae Kim
Abstract
Objective: To determine the frequency and clinical significance of oligohydramnios in patients with preterm labor and intact membranes.
Study design: An amniotic fluid index (AFI) was determined before amniocentesis (<24 h) in 272 patients with preterm labor and intact membranes (<35 weeks of gestation). Amniotic fluid (AF) was cultured for aerobic and anaerobic bacteria and genital mycoplasmas, and assayed for matrix metalloproteinase-8 (MMP-8). Non-parametric statistical techniques and survival analysis were used.
Results: 1) The overall prevalence of oligohydramnios (AFI of ≤5 cm) in patients with preterm labor and intact membranes was 2.6% (7/272); 2) patients with oligohydramnios had a higher frequency of AF infection and/or inflammation than those without oligohydramnios [85.7% (6/7) vs. 32.8% (87/265); P<0.01]; 3) patients with oligohydramnios had a higher median AF MMP-8 concentration than those without oligohydramnios [median 664.2 (range 16.6–3424.7) ng/mL vs. median 2.3 (range <0.3–6142.6) ng/mL; P<0.01]; 4) women with preterm labor and oligohydramnios had a shorter interval to delivery than those without oligohydramnios [median 18 h (range 0–74 h) vs. median 311 h (range 0–3228 h); P<0.01], and this difference remained significant after adjusting for gestational age and the presence or absence of AF infection/inflammation.
Conclusion: Patients with preterm labor and oligohydramnios are at increased risk for impending preterm delivery and intra-amniotic inflammation and, therefore, may benefit from careful surveillance.
©2011 by Walter de Gruyter Berlin New York
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- Letters to the Editor
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- Congress Calendar
Articles in the same Issue
- Recommendations and guidelines for perinatal practice
- Twin-to-twin transfusion syndrome (TTTS)*
- Expert panel recommendation
- Expert recommendations for the diagnosis and treatment of iron-deficiency anemia during pregnancy and the postpartum period in the Asia-Pacific region
- Review article
- Weight gain and dietary intake during pregnancy in industrialized countries – a systematic review of observational studies
- Original articles – Obstetrics
- Clinical significance of oligohydramnios in patients with preterm labor and intact membranes*,**
- Placental volume and vascularization flow indices by 3D power Doppler US using VOCAL technique and correlation with IGF-1, free beta-hCG, PAPP-A, and uterine artery Doppler at 11–14 weeks of pregnancy
- The impact of umbilical and uterine artery Doppler indices on antenatal course, labor and delivery in a low-risk primigravid population
- C-reactive protein levels at pre-/post-indicated cervical cerclage predict very preterm birth
- Role of the vascular endothelial growth factor in the inverse relationship between increased nuchal translucency thickness and fetomaternal transfusion
- Birth defects among a cohort of infants born to HIV-infected women on antiretroviral medication
- Original articles – Fetus
- Neurobehavioral continuity from fetus to neonate
- Obstetrical risk factors for focal intestinal perforation in very low birth weight infants
- Assessment of nuchal translucency thickness and the fetal anatomy in the first trimester of pregnancy by two- and three-dimensional ultrasonography: a pilot study
- Why are monozygotic twins different?
- Original article – Newborn
- The impact of clinical maternal chorioamnionitis on neurological and psychological sequelae in very-low-birth weight infants: a case-control study
- Short communication
- Normal fasting plasma glucose levels during pregnancy: a hospital-based study
- Letters to the Editor
- Syndrome of inappropriate antidiuretic hormone secretion after cesarean section complicated with hemorrhage
- Acceptability of the fetal electrocardiographic (STAN®) monitoring system by staff at a high-risk maternity unit
- Reply: A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
- Congress calendar
- Congress Calendar
