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Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
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Mamoru Morikawa
Veröffentlicht/Copyright:
13. August 2010
Abstract
Objective: We investigated whether ascites samples obtained from pregnant women during cesarean sections contained antithrombin because it is unknown whether antithrombin escapes from the blood and passes into the interstitial space during pregnancy.
Methods: The concentration and activity levels of antithrombin were determined in six ascites samples obtained from six consecutive women who exhibited generalized edema, ascites, and a gradual decline in antithrombin activity.
Results: All six ascites samples contained antithrombin (mean±SD, 4.9±2.2 mg/dL; range, 2.7–8.8 mg/dL) and exhibited an antithrombin activity level of 15.5±6.0% (range, 10–24%).
Conclusions: Antithrombin escapes from the blood into the interstitial space in pregnant women. This phenomenon partially explains the gradual decline in antithrombin activity observed in these six pregnant women with generalized edema and large volumes of ascites.
Received: 2010-3-14
Revised: 2010-6-1
Accepted: 2010-6-7
Published Online: 2010-08-13
Published Online: 2010-08-13
Published in Print: 2010-11-01
©2010 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Editorial
- Late motherhood and cesarean delivery
- Review article
- Oxygen and oxidative stress in bronchopulmonary dysplasia
- A statement of the World Association of Perinatal Medicine
- Ethical dimensions of periviability
- Opinion Paper
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
- Original articles – Obstetrics
- Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
- Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
- Genome profiles in maternal blood during early onset preeclampsia and towards term
- Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
- Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
- Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
- A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
- Long chain polyunsaturated fatty acids in mothers of preterm babies
- Original articles – Fetus
- The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes
- The source of error in the estimation of intertwin birth weight discordance
- Original articles – Newborn
- Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia
- Effect of prenatal tobacco smoke exposure on fetal growth potential
- Prenatal tobacco exposure and cortisol levels in infants of teen mothers
- Letter to the editor
- Mediastinal tumor during pregnancy: a multidisciplinary approach
- Neonatal abstinence syndrome (NAS) after intrauterine exposure to tramadol
- Fetoscopic laser photocoagulation and uterine wall defects
- Congress Calendar
- Congress Calendar
Schlagwörter für diesen Artikel
Antithrombin;
ascites;
gestational edema;
pre-eclampsia;
vascular permeability
Artikel in diesem Heft
- Editorial
- Late motherhood and cesarean delivery
- Review article
- Oxygen and oxidative stress in bronchopulmonary dysplasia
- A statement of the World Association of Perinatal Medicine
- Ethical dimensions of periviability
- Opinion Paper
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
- Original articles – Obstetrics
- Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
- Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
- Genome profiles in maternal blood during early onset preeclampsia and towards term
- Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
- Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
- Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
- A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
- Long chain polyunsaturated fatty acids in mothers of preterm babies
- Original articles – Fetus
- The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes
- The source of error in the estimation of intertwin birth weight discordance
- Original articles – Newborn
- Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia
- Effect of prenatal tobacco smoke exposure on fetal growth potential
- Prenatal tobacco exposure and cortisol levels in infants of teen mothers
- Letter to the editor
- Mediastinal tumor during pregnancy: a multidisciplinary approach
- Neonatal abstinence syndrome (NAS) after intrauterine exposure to tramadol
- Fetoscopic laser photocoagulation and uterine wall defects
- Congress Calendar
- Congress Calendar
