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Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia

  • Hyun Ju Lee , Chang Won Choi , Beyong Il Kim , Ee-Kyung Kim , Han-Suk Kim , Jung-Hwan Choi , Myong Jin Lee and Eun Gyeong Yang
Published/Copyright: August 13, 2010
Journal of Perinatal Medicine
From the journal Volume 38 Issue 6

Abstract

Aim: To investigate serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia (BPD) induced by intra-amniotic lipopolysaccharide (LPS) administration and postnatal hyperoxia (85%).

Methods: We evaluated histological changes of the lungs and compared the levels of interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), and protein carbonyl in lung tissue on days 1, 7, and 14 after birth in a rat model of BPD.

Results: The inhibition of alveolarization was sustained in the LPS plus hyperoxia group from day 7 to 14, whereas alveolarization resumed in the hyperoxia group after oxygen exposure was withdrawn at day 7. Administration of LPS alone did not adversely affect lung morphometry. IL-6 levels showed transient overexpression at day 1 in the LPS-treated groups, but decreased at days 7 and 14. VEGF protein levels were elevated in the LPS-treated groups, but not in the hyper-oxia and control groups at days 1, 7, and 14. Exposure to hyperoxia affected protein carbonyl levels in the hyperoxia group at days 7 and 14.

Conclusion: Lung injury induced by intra-amniotic inflammation and postnatal hyperoxia may be due to inhibition of alveolarization without recovery even after withdrawal of oxygen.

Keywords: Bronchopulmonary dysplasia; chorioamnionitis; interleukin-6; protein carbonyl; vascular endothelial growth factor
Corresponding author: Chang Won Choi, MD Department of Pediatrics Seoul National University Bundang Hospital 166 Gumiro Bundang-gu Seongnam-si Gyeonggi-do 463-707 Korea Tel.: +82-31-787-7286 Fax: +82-31-787-4054
Received: 2010-2-21
Revised: 2010-4-12
Accepted: 2010-4-28
Published Online: 2010-08-13
Published Online: 2010-08-13
Published in Print: 2010-11-01

©2010 by Walter de Gruyter Berlin New York

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  4. Oxygen and oxidative stress in bronchopulmonary dysplasia
  5. A statement of the World Association of Perinatal Medicine
  6. Ethical dimensions of periviability
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  24. Effect of prenatal tobacco smoke exposure on fetal growth potential
  25. Prenatal tobacco exposure and cortisol levels in infants of teen mothers
  26. Letter to the editor
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https://doi.org/10.1515/jpm.2010.091
Keywords for this article
Bronchopulmonary dysplasia; chorioamnionitis; interleukin-6; protein carbonyl; vascular endothelial growth factor

Articles in the same Issue

  1. Editorial
  2. Late motherhood and cesarean delivery
  3. Review article
  4. Oxygen and oxidative stress in bronchopulmonary dysplasia
  5. A statement of the World Association of Perinatal Medicine
  6. Ethical dimensions of periviability
  7. Opinion Paper
  8. The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
  9. Original articles – Obstetrics
  10. Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
  11. Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
  12. Genome profiles in maternal blood during early onset preeclampsia and towards term
  13. Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
  14. Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
  15. Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
  16. Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
  17. A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
  18. Long chain polyunsaturated fatty acids in mothers of preterm babies
  19. Original articles – Fetus
  20. The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes
  21. The source of error in the estimation of intertwin birth weight discordance
  22. Original articles – Newborn
  23. Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia
  24. Effect of prenatal tobacco smoke exposure on fetal growth potential
  25. Prenatal tobacco exposure and cortisol levels in infants of teen mothers
  26. Letter to the editor
  27. Mediastinal tumor during pregnancy: a multidisciplinary approach
  28. Neonatal abstinence syndrome (NAS) after intrauterine exposure to tramadol
  29. Fetoscopic laser photocoagulation and uterine wall defects
  30. Congress Calendar
  31. Congress Calendar
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