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Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
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Alon Shrim
Veröffentlicht/Copyright:
13. August 2010
Abstract
Objective: To assess complications of very advanced maternal age (VAMA) pregnancies ≥45 years with and without egg donation (ED).
Study design: Obstetric and neonatal complications were studied in 20,659 singleton pregnancies according to three maternal age groups: 20–39, 40–44 [advanced maternal age (AMA)] and ≥45 years (VAMA). Twenty pregnancies within the AMA/LAMA group that were achieved with ED were compared with age-matched controls.
Results: AMA mothers were more likely to have higher rates of preterm deliveries (OR 1.25), cesarean sections (OR 1.84) hypertension (OR 1.71) and diabetes (OR 2.45). Their newborns were more frequently small for gestational age (OR 1.30), and were more likely to have high rates of respiratory distress syndrome (OR 1.66), neonatal intensive care admission (OR 1.40) and perinatal/neonatal mortality (OR 1.83). VAMA pregnancies had >50% cesarean section rate and a high rate of diabetes (OR 2.29), hypertension (OR 1.54) and postpartum hemorrhage (OR 5.38). Congenital anomalies were more common among ED pregnancies.
Conclusions: The higher rate of pregnancy complications for women ≥40 years is not further increased after 45 years of age.
Received: 2010-3-25
Revised: 2010-4-23
Accepted: 2010-4-26
Published Online: 2010-08-13
Published Online: 2010-08-13
Published in Print: 2010-11-01
©2010 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Editorial
- Late motherhood and cesarean delivery
- Review article
- Oxygen and oxidative stress in bronchopulmonary dysplasia
- A statement of the World Association of Perinatal Medicine
- Ethical dimensions of periviability
- Opinion Paper
- The role of melatonin in post-partum psychosis and depression associated with bipolar disorder
- Original articles – Obstetrics
- Low maternal serum matrix metalloproteinase (MMP)-2 concentrations are associated with preterm labor and fetal inflammatory response
- Comparison of complications in second trimester amniocentesis performed with 20G, 21G and 22G needles
- Genome profiles in maternal blood during early onset preeclampsia and towards term
- Comparative analysis of insulin-like growth factor binding protein-1 (IGFBP-1), placental alpha-microglobulin-1 (PAMG-1) and nitrazine test to diagnose premature rupture of membranes in pregnancy
- Evidence of the escape of antithrombin from the blood into the interstitial space in pregnant women
- Characterization of the myometrial transcriptome and biological pathways of spontaneous human labor at term
- Does very advanced maternal age, with or without egg donation, really increase obstetric risk in a large tertiary center?
- A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
- Long chain polyunsaturated fatty acids in mothers of preterm babies
- Original articles – Fetus
- The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranes
- The source of error in the estimation of intertwin birth weight discordance
- Original articles – Newborn
- Serial changes of lung morphology and biochemical profiles in a rat model of bronchopulmonary dysplasia induced by intra-amniotic lipopolysaccharide and postnatal hyperoxia
- Effect of prenatal tobacco smoke exposure on fetal growth potential
- Prenatal tobacco exposure and cortisol levels in infants of teen mothers
- Letter to the editor
- Mediastinal tumor during pregnancy: a multidisciplinary approach
- Neonatal abstinence syndrome (NAS) after intrauterine exposure to tramadol
- Fetoscopic laser photocoagulation and uterine wall defects
- Congress Calendar
- Congress Calendar
