Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome
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Guanghui Li
Abstract
Aims: To investigate metabolic characteristics and perinatal outcomes of gestational diabetes mellitus (GDM) in women with polycystic ovary syndrome (PCOS).
Methods: We evaluated 34 GDM in women with PCOS and 70 GDM in women without PCOS in this prospective study. All GDM women were treated with medical nutrition therapy (MNT). Pre-pregnancy clinical data, fasting glucose, fasting insulin (FINS), blood lipid, homeostasis model assessment index of insulin resistance (HOMA-IR) and perinatal outcomes were investigated.
Results: GDM in women with PCOS had higher pre-pregnancy body mass index (BMI), higher incidence of overweight than in the non-PCOS group (each P<0.001). Incidence of history of infertility was also significantly higher in the PCOS group than in the non-PCOS group (20.6% vs. 2.9%, P<0.01). A higher incidence of early pregnancy loss (EPL) was found in the PCOS group than in the non-PCOS group (20.6% vs. 7.1%, P<0.05). Significantly higher in vitro fertilization and embryo transfer (IVF-ET) rate and insulin administration was also observed in the PCOS group than in the controls. No significant difference was found in the prevalence of preeclampsia, premature delivery, macrosomia, fetal death and neonatal congenital anomaly between GDM in women with and without PCOS (all P<0.05).
Conclusions: Compared with the controls, no significant increase in the incidence of adverse perinatal outcomes was detected in GDM in women with PCOS by appropriate management.
©2010 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Expert panel recommendation
- A template for defining the perinatal care of monochorionic twins: the Istanbul international ad hoc committee
- Recommendations and guidelines for perinatal practice
- Guidelines for the management of postterm pregnancy
- Review article
- Unequal but monozygous: a history of twin-twin transfusion syndrome
- Original articles – Obstetrics
- Retinol binding protein 4 – a novel association with early-onset preeclampsia
- Metabolic parameters and perinatal outcomes of gestational diabetes mellitus in women with polycystic ovary syndrome
- Retinol-binding protein 4: a novel adipokine implicated in the genesis of LGA in the absence of gestational diabetes mellitus
- Preferences of caregiver when experiencing nausea and vomiting during pregnancy
- Original articles – Fetus
- Pentraxin 3 in amniotic fluid: a novel association with intra-amniotic infection and inflammation
- Puerperal symphysis fundus distance: normal values
- Comparison of non-invasive fetal electrocardiogram to Doppler cardiotocogram during the 1st stage of labor
- Acceptability of the fetal electrocardiographic (STAN®) monitoring system by staff at a high risk maternity unit
- Comparison of a computer system evaluation of intrapartum cardiotocographic events and a consensus of clinicians
- Loss of FHR variability diagnosed by frequency analysis
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- Original articles – Newborn
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- Letters to the Editor
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