Subclinical cardiac impairments in fetuses conceived through assisted reproductive technology by speckle tracking echocardiography
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Yipeng Gao
Abstract
Objectives
To evaluate the changes of cardiac morphology and function in fetuses conceived through assisted reproductive technologies (ART) by speckle tracking echocardiography.
Methods
A retrospective study was conducted in 101 spontaneously conceived (SC) fetuses and 99 ART-conceived ones. Fetal echocardiography was performed, fetal cardiac morphology and function were analyzed using two-dimensional speckle tracking software, including global sphericity index (GSI), global longitudinal strain (GLS), fractional area change (FAC) of the left and right ventricles, as well as segmental sphericity index (SI), end-diastolic diameter (ED), and fractional shortening (FS) in 24 segments.
Results
Compared to the SC fetuses, the ART-conceived fetuses exhibited decreased GSI (median [interquartile range], 1.22 [1.16–1.27] vs. 1.18 [1.11–1.24], p=0.007), decreased right ventricular GLS (24.9 [21.5–27.6] vs. 23.2 [20.4–26.8], p=0.026), and decreased right ventricular FAC (mean ± standard deviation, 39.7 ± 6.4 vs. 37.2 ± 7.1, p=0.003). Analysis of the 24 segments showed that ART-conceived fetuses had reduced SI in the apical segments of right ventricle and increased ED in several segments of the right ventricle.
Conclusions
Fetuses conceived through ART had a more spherical shape of the global heart and predominantly right-sided cardiac remodeling and systolic function impairment.
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Research ethics: The study protocol was approved by the Medical Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (No. TJ-IRB20230825).
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Informed consent: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The raw data can be obtained on request from the corresponding author.
References
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/jpm-2023-0470).
© 2024 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Opinion Paper
- The importance of professional responsibility and fetal viability in the management of abortion
- Corner of Academy
- Multifetal pregnancy reductions and selective fetocide in a tertiary referral center – a retrospective cohort study
- Original Articles – Obstetrics
- Cervical length as a screening tool for preterm birth in twin pregnancies: a systematic review and critical evaluation of quality clinical practice guidelines
- Determinants of prematurity in urban Indonesia: a meta-analysis
- Predictors of planned home birth before and during the COVID-19 pandemic
- Sensitivity of antenatal ultrasound in diagnosing posterior placenta accreta spectrum disorders
- The prognostic role of CRL discordance in first trimester ultrasound
- Evaluation of postpartum shock index in hypertensive diseases of pregnancy: a case-control study from a tertiary reference center
- Original Articles – Fetus
- Prenatal diagnosis of right aortic arch: associated anomalies and fetal prognosis according to different subtypes
- Fetal brain development in pregnancies complicated by gestational diabetes mellitus
- The association between parental SARS-CoV-2 infection in pregnancy and fetal growth restriction
- Subclinical cardiac impairments in fetuses conceived through assisted reproductive technology by speckle tracking echocardiography
- Original Articles – Neonates
- Coagulation assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infected pregnant women and their offspring by using rotational thromboelastometry (ROTEM)
- Comprehensive appraisal of pregnancy and neonatal outcomes in singleton pregnancies conceived via in vitro fertilization in the USA (2016–2021)
- Influence of donor characteristics on the milk donation volume and microbiological quality of donated human milk in first 3 years of work of the Croatian human milk bank-retrospective observational study
Artikel in diesem Heft
- Frontmatter
- Opinion Paper
- The importance of professional responsibility and fetal viability in the management of abortion
- Corner of Academy
- Multifetal pregnancy reductions and selective fetocide in a tertiary referral center – a retrospective cohort study
- Original Articles – Obstetrics
- Cervical length as a screening tool for preterm birth in twin pregnancies: a systematic review and critical evaluation of quality clinical practice guidelines
- Determinants of prematurity in urban Indonesia: a meta-analysis
- Predictors of planned home birth before and during the COVID-19 pandemic
- Sensitivity of antenatal ultrasound in diagnosing posterior placenta accreta spectrum disorders
- The prognostic role of CRL discordance in first trimester ultrasound
- Evaluation of postpartum shock index in hypertensive diseases of pregnancy: a case-control study from a tertiary reference center
- Original Articles – Fetus
- Prenatal diagnosis of right aortic arch: associated anomalies and fetal prognosis according to different subtypes
- Fetal brain development in pregnancies complicated by gestational diabetes mellitus
- The association between parental SARS-CoV-2 infection in pregnancy and fetal growth restriction
- Subclinical cardiac impairments in fetuses conceived through assisted reproductive technology by speckle tracking echocardiography
- Original Articles – Neonates
- Coagulation assessment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infected pregnant women and their offspring by using rotational thromboelastometry (ROTEM)
- Comprehensive appraisal of pregnancy and neonatal outcomes in singleton pregnancies conceived via in vitro fertilization in the USA (2016–2021)
- Influence of donor characteristics on the milk donation volume and microbiological quality of donated human milk in first 3 years of work of the Croatian human milk bank-retrospective observational study
