Novel method for trisomy 21 screening in the first trimester of pregnancy: fetal brain angle
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Mehmet Fatih Karslı
und
Cihat Şen
Abstract
Objectives
The present study was performed to examine the utility of a new first trimester marker called the “brain angle” (BA) in screening for trisomy 21. We postulate that differences in the midbrain anatomy between euploid fetuses and those that are affected by trisomy 21 are reflected in changes in BA measurements.
Methods
In fetuses at 11+0–13+6 weeks of gestations, which were at high risk for trisomy 21, the angle was measured between the line crossing the thalamus and mesencephalon cranial border tangentially and the line crossing the brainstem lower limit. This angle was compared between fetuses with trisomy 21 (based on karyotyping) and those with a normal karyotype.
Results
Trisomy 21 was detected in 45 (8%) of 560 fetuses. Receiver operating characteristic analysis showed that, at BA≥94°, the sensitivity and specificity for determining trisomy 21 were 97.8% (95% CI=88.2–99.9%) and 100% (95% CI=99.2–100%), respectively.
Conclusions
Fetal BA appears to be a promising new first trimester marker in screening for trisomy 21.
Acknowledgments
We would like to acknowledge the contribution of M. Yılmaz in drawing of the figure.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The Cerrahpasa School of Medicine Ethics Review Committee approved the trial (approval no. 17-A-39).
References
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Obituary
- Obituary ‒ Erich Saling (1925–2021)
- Editorial
- The journal Case Reports in Perinatal Medicine starts with Open Access
- Review
- Physical exercise in pregnancy: benefits, risks and prescription
- Corner of Academy
- Association between latency period and perinatal outcomes after preterm premature rupture of membranes at 32–37 weeks of gestation: a perinatal registry-based cohort study
- Original Articles – Obstetrics
- Dosage escalation of antenatal steroids in preterm twin pregnancies does not improve long-term outcome
- Fetoscopic laser ablation therapy in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome treated at a single centre over 10 years: a retrospective study
- Induced abortion and COVID-19 as contributing factors to declining fertility in Sardinia
- Cardiotocographic features in COVID-19 infected pregnant women
- The relation between cigarette smoking with delivery outcomes. An evaluation of a database of more than nine million deliveries
- Second trimester prediction of gestational diabetes: maternal analytes as an additional screening tool
- Perinatal outcomes in pregnancies complicated by acute pancreatitis
- The quality of intrapartum cardiotocography in preterm labour
- Novel method for trisomy 21 screening in the first trimester of pregnancy: fetal brain angle
- Assessment of intrahepatic cholestasis in pregnancy and the effect of disease severity on transient tachypnea in the newborn in uncomplicated fetuses
- Original Articles – Fetus
- The role of the brain-sparing effect of growth-restricted fetuses in newborn germinal matrix/intraventricular hemorrhage
- Original Articles – Neonates
- Postnatal diuretics, weight gain and home oxygen requirement in extremely preterm infants
- Letters to the Editor
- Anxiety and fear in pregnant women of being infected by COVID-19 in new Delta pandemic
- Peripheral and uterine blood viscoelastic testing parameters during postpartum hemorrhage
- Comment on “Clinical manifestation, outcomes in pregnant women with COVID-19 and the possibility of vertical transmission: a systematic review of the current data”
- Reply to a letter commenting on “Clinical manifestation, outcomes in pregnant women with COVID-19 and the possibility of vertical transmission: a systematic review of the current data”
- Book Review
- Michael Obladen: Oxford Textbook of The Newborn – A Cultural and Medical History
- Acknowledgment
- Acknowledgment
Artikel in diesem Heft
- Frontmatter
- Obituary
- Obituary ‒ Erich Saling (1925–2021)
- Editorial
- The journal Case Reports in Perinatal Medicine starts with Open Access
- Review
- Physical exercise in pregnancy: benefits, risks and prescription
- Corner of Academy
- Association between latency period and perinatal outcomes after preterm premature rupture of membranes at 32–37 weeks of gestation: a perinatal registry-based cohort study
- Original Articles – Obstetrics
- Dosage escalation of antenatal steroids in preterm twin pregnancies does not improve long-term outcome
- Fetoscopic laser ablation therapy in monochorionic diamniotic twin pregnancies with twin-to-twin transfusion syndrome treated at a single centre over 10 years: a retrospective study
- Induced abortion and COVID-19 as contributing factors to declining fertility in Sardinia
- Cardiotocographic features in COVID-19 infected pregnant women
- The relation between cigarette smoking with delivery outcomes. An evaluation of a database of more than nine million deliveries
- Second trimester prediction of gestational diabetes: maternal analytes as an additional screening tool
- Perinatal outcomes in pregnancies complicated by acute pancreatitis
- The quality of intrapartum cardiotocography in preterm labour
- Novel method for trisomy 21 screening in the first trimester of pregnancy: fetal brain angle
- Assessment of intrahepatic cholestasis in pregnancy and the effect of disease severity on transient tachypnea in the newborn in uncomplicated fetuses
- Original Articles – Fetus
- The role of the brain-sparing effect of growth-restricted fetuses in newborn germinal matrix/intraventricular hemorrhage
- Original Articles – Neonates
- Postnatal diuretics, weight gain and home oxygen requirement in extremely preterm infants
- Letters to the Editor
- Anxiety and fear in pregnant women of being infected by COVID-19 in new Delta pandemic
- Peripheral and uterine blood viscoelastic testing parameters during postpartum hemorrhage
- Comment on “Clinical manifestation, outcomes in pregnant women with COVID-19 and the possibility of vertical transmission: a systematic review of the current data”
- Reply to a letter commenting on “Clinical manifestation, outcomes in pregnant women with COVID-19 and the possibility of vertical transmission: a systematic review of the current data”
- Book Review
- Michael Obladen: Oxford Textbook of The Newborn – A Cultural and Medical History
- Acknowledgment
- Acknowledgment
