Perinatal outcomes in pregnancies complicated by acute pancreatitis

Emmy Cai; Nicholas Czuzoj-Shulman; Haim A. Abenhaim

doi:10.1515/jpm-2020-0580

Article

Perinatal outcomes in pregnancies complicated by acute pancreatitis

Emmy Cai , Nicholas Czuzoj-Shulman and Haim A. Abenhaim

Published/Copyright: September 15, 2021

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From the journal Journal of Perinatal Medicine Volume 50 Issue 1

Abstract

Objectives

Acute pancreatitis is a rare condition that can be associated with significant complications. The objective of this study is to evaluate the maternal and newborn outcomes associated with acute pancreatitis in pregnancy.

Methods

A retrospective cohort study using the Healthcare Cost and Utilization Project-Nationwide Inpatient Sample from the United States was performed. All pregnant patients with acute pancreatitis were identified using International Classification of Disease-9 coding from 1999 to 2015. The effect of acute pancreatitis on maternal and neonatal outcomes in pregnancy was evaluated using multivariate logistic regression, while adjusting for baseline maternal characteristics.

Results

From 1999 to 2015, there were a total of 13,815,919 women who gave birth. There were a total of 14,258 admissions of women diagnosed with acute pancreatitis, including 1,756 who delivered during their admission and 12,502 women who were admitted in the antepartum period and did not deliver during the same admission. Acute pancreatitis was associated with increased risk of prematurity, OR 3.78 (95% CI 3.38–4.22), preeclampsia, 3.81(3.33–4.36), postpartum hemorrhage, 1.90(1.55–2.33), maternal death, 9.15(6.05–13.85), and fetal demise, 2.60(1.86–3.62) among women diagnosed with acute pancreatitis. Among women with acute pancreatitis, delivery was associated with increased risk of requiring transfusions, 6.06(4.87–7.54), developing venous thromboembolisms, 2.77(1.83–4.18), acute respiratory failure, 3.66(2.73–4.91), and disseminated intravascular coagulation, 8.12(4.12–16.03).

Conclusions

Acute pancreatitis in pregnancy is associated with severe complications, such as maternal and fetal death. Understanding the risk factors that may lead to these complications can help prevent or minimize them through close fetal and maternal monitoring.

Keywords: acute pancreatitis; maternal outcomes; neonatal outcomes; pancreatitis

Corresponding author: Haim A. Abenhaim, MD, MPH, Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, 3755 Chemin de la Côte-Sainte-Catherine, Montreal, QC H3T 1E2, Canada; and Centre for Clinical Epidemiology, Jewish General Hospital, Montreal, QC, Canada, Phone: +1 514 340 8222 x 24187, Fax: +1 514 340 7564, E-mail: haim.abenhaim@gmail.com

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: This study was based on data from a pre-existing administrative database (Healthcare Cost and Utilization Project-Nationwide Inpatient Sample).
Ethical approval: Data used to perform the analyses were publicly available, thus Institutional Review Board approval was not required, according to the 2010 Tri-Council Policy Statement.

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Received: 2020-12-07

Accepted: 2021-08-11

Published Online: 2021-09-15

Published in Print: 2022-01-27

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Articles in the same Issue

https://doi.org/10.1515/jpm-2020-0580

Keywords for this article

acute pancreatitis; maternal outcomes; neonatal outcomes; pancreatitis