Correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes
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Lin Liang
Abstract
Objective
To investigate the correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes and to provide a scientific basis for improving ovulation induction programs.
Methods
In total, we collected 277 follicular fluid specimens from patients undergoing in vitro fertilization (IVF) treatment in our hospital. Eighteen cases of aneuploidy embryos were identified. The follicular fluid of these aneuploidy embryos was used for the study. According to the case and control 1:5 paired design, we selected five age-matched controls with healthy births following IVF for each aneuploidy case. Concentrations of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2) and vascular endothelial growth factor (VEGF) in the follicular fluid were measured. Conditional logistic regression was used to analyze the relationship between aneuploidy pregnancy and the concentrations of various hormones and VEGF in the follicular fluid as well as the number of acquired oocytes.
Results
Multivariate conditional logistic regression showed that of all the factors analyzed, only FSH [odds ratio (OR) = 1.300, 95% confidence interval (CI), 1.091–1.548, P = 0.003] level in the follicular fluid and the number of acquired oocytes (OR = 1.179, 95% CI, 1.070–1.299, P = 0.001) were closely related to aneuploidy pregnancy. No other factors were found to be associated with aneuploidy pregnancy.
Conclusion
FSH concentrations in the follicular fluid are risk factors for aneuploidy pregnancies. The higher the number of eggs, the higher the risk of aneuploidy. These findings may help improve ovulation induction programs.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: This work was supported by the Natural Science Foundation of China (81660542) and the Inner Mongolia Natural Science Fund (2018MS08091).
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- 10.1515/jpm-2020-frontmatter1
- Review
- Delivery room handling of the newborn
- Original Articles – Obstetrics
- Examining the validity of a predictive model for vaginal birth after cesarean
- Correlation between endometrial thickness and perinatal outcome for pregnancies achieved through assisted reproduction technology
- Significance of the routine first-trimester antenatal screening program for aneuploidy in the assessment of the risk of placenta accreta spectrum disorders
- A decade’s experience in primipara, term, singleton, vertex parturients with a sustained low rate of CD
- Survey of alongside midwifery-led care in North Rhine-Westfalia, Germany
- Correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes
- Bacteriuria in pregnancy varies with the ambiance: a retrospective observational study at a tertiary hospital in Doha, Qatar
- Microarray findings in pregnancies with oligohydramnios – a retrospective cohort study and literature review
- Lifestyle characteristics of parental electronic cigarette and marijuana users: healthy or not?
- Influence of maternal HIV infection on fetal thymus size
- Original Articles – Fetus
- Clinical outcome of prenatally suspected cardiac rhabdomyomas of the fetus
- Original Articles – Newborns
- Prolonged ventilation and postnatal growth of preterm infants
- Letter to the Editor
- Neonatal sepsis associated with Lactobacillus supplementation
Articles in the same Issue
- 10.1515/jpm-2020-frontmatter1
- Review
- Delivery room handling of the newborn
- Original Articles – Obstetrics
- Examining the validity of a predictive model for vaginal birth after cesarean
- Correlation between endometrial thickness and perinatal outcome for pregnancies achieved through assisted reproduction technology
- Significance of the routine first-trimester antenatal screening program for aneuploidy in the assessment of the risk of placenta accreta spectrum disorders
- A decade’s experience in primipara, term, singleton, vertex parturients with a sustained low rate of CD
- Survey of alongside midwifery-led care in North Rhine-Westfalia, Germany
- Correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes
- Bacteriuria in pregnancy varies with the ambiance: a retrospective observational study at a tertiary hospital in Doha, Qatar
- Microarray findings in pregnancies with oligohydramnios – a retrospective cohort study and literature review
- Lifestyle characteristics of parental electronic cigarette and marijuana users: healthy or not?
- Influence of maternal HIV infection on fetal thymus size
- Original Articles – Fetus
- Clinical outcome of prenatally suspected cardiac rhabdomyomas of the fetus
- Original Articles – Newborns
- Prolonged ventilation and postnatal growth of preterm infants
- Letter to the Editor
- Neonatal sepsis associated with Lactobacillus supplementation
