Microarray findings in pregnancies with oligohydramnios – a retrospective cohort study and literature review
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Amihood Singer
Abstract
Objective
To explore the risk for abnormal chromosomal microarray analysis (CMA) findings in pregnancies with oligohydramnios.
Methods
Data from all CMA analyses performed due to oligohydramnios between 2013 and 2017 were retrospectively obtained from the Israeli Ministry of Health database. The rate of clinically significant (pathogenic and likely pathogenic) findings was compared to a local cohort of pregnancies with normal ultrasound, yielding a 1.4% rate of abnormal CMA results. In addition, a search was conducted through the PubMed database addressing the issue.
Results
Fifty CMA analyses were performed due to oligohydramnios. The 2% risk for clinically significant CMA finding in pregnancies with oligohydramnios did not differ from the control population of 5541 pregnancies with normal ultrasound – relative risk (RR) 1.4 [95% confidence interval (CI) 0.2–10.2]. Literature search yielded 394 titles, of which four relevant articles were selected, all using fetal karyotyping.
Conclusion
There is yet insufficient evidence to support invasive prenatal testing in pregnancies with isolated oligohydramnios.
Acknowledgments
We are grateful to all Israeli genetic counselors and laboratory workers engaged in the prenatal evaluation of fetal malformations, who made this study possible.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2019-0228).
©2020 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- 10.1515/jpm-2020-frontmatter1
- Review
- Delivery room handling of the newborn
- Original Articles – Obstetrics
- Examining the validity of a predictive model for vaginal birth after cesarean
- Correlation between endometrial thickness and perinatal outcome for pregnancies achieved through assisted reproduction technology
- Significance of the routine first-trimester antenatal screening program for aneuploidy in the assessment of the risk of placenta accreta spectrum disorders
- A decade’s experience in primipara, term, singleton, vertex parturients with a sustained low rate of CD
- Survey of alongside midwifery-led care in North Rhine-Westfalia, Germany
- Correlation between aneuploidy pregnancy and the concentration of various hormones and vascular endothelial factor in follicular fluid as well as the number of acquired oocytes
- Bacteriuria in pregnancy varies with the ambiance: a retrospective observational study at a tertiary hospital in Doha, Qatar
- Microarray findings in pregnancies with oligohydramnios – a retrospective cohort study and literature review
- Lifestyle characteristics of parental electronic cigarette and marijuana users: healthy or not?
- Influence of maternal HIV infection on fetal thymus size
- Original Articles – Fetus
- Clinical outcome of prenatally suspected cardiac rhabdomyomas of the fetus
- Original Articles – Newborns
- Prolonged ventilation and postnatal growth of preterm infants
- Letter to the Editor
- Neonatal sepsis associated with Lactobacillus supplementation
