Abstract
Objective: The aim of this study was to investigate the levels of different isoforms of soluble human leukocyte antigen-G (sHLA-G) in maternal plasma during early and late pregnancy, and to investigate the expression of sHLA-G isoforms in women with early or late-onset severe preeclampsia.
Methods: This prospective, nested, case-control study was performed in 24 early-onset severe preeclamptic, 34 late-onset severe preeclamptic, and 74 uncomplicated pregnant women. Plasma levels of sHLA-G1/5 were measured using ELISA.
Results: Plasma sHLA-G1 levels in women with late-onset severe preeclampsia were markedly lower compared with normal controls (median: 0 vs. 1.22 ng/mL) at the first trimester, and plasma sHLA-G1 levels in women with early-onset severe preeclampsia were markedly lower compared with normal controls at the second (median: 0 vs. 1.24 ng/mL) and third (median: 0 vs. 1.34 ng/mL) trimesters. There was no difference between the late-onset and early-onset groups at three trimesters. As for sHLA-G5, there was no difference in concentrations among the three groups at any time point. However, compared with controls, more women with early- or late-onset severe preeclampsia had undetectable sHLA-G5 levels in the first (71.4% and 76.2% vs. 14.1%), second (75.0% and 73.3% vs. 19.0%), and third (100.0% and 70.4% vs. 14.8%, respectively) trimester (all P<0.05). sHLA-G1 levels in the first (odds ratio [OR]=0.254, 95% confidence interval [CI]=0.109–0.591, P=0.010), second (OR=0.315, 95% CI=0.158–0.627, P=0.001), and third (OR=0.170, 95% CI=0.054–0.533, P=0.002) trimester was a risk factor for severe preeclampsia.
Conclusion: Severe preeclampsia was associated with low/undetectable maternal plasma levels of sHLA-G. Low sHLA-G1 levels might be a risk marker for severe preeclampsia.
Acknowledgments
This work was supported by grants from the National Natural Science Foundation of China (No. 81070509).
References
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The authors stated that there are no conflicts of interest regarding the publication of this article.
©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- The emergence of obstetric medicine
- Mini review
- Folate status and health: challenges and opportunities
- Original articles - Obstetrics
- Increased levels of serum clusterin is associated with intrauterine growth restriction and adverse pregnancy outcomes in preeclampsia
- The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy
- Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia
- Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia
- The prognostic value of first-trimester cystatin C levels for gestational complications
- Experiences of 6 years quality assurance in obstetrics in Nigeria – a critical review of results and obstacles
- Are there anamnestic risk factors for iron deficiency in pregnancy? Results from a feasibility study
- Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
- Pregnancy outcomes among renal transplant recipients and patients with end-stage renal disease on dialysis
- Are pregnant women safer in motor vehicle accidents?
- Amniotic fluid as a source of multipotent cells for clinical use
- Original articles - Newborn
- Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection
- Effects of preeclampsia on the amplitude integrated electroencephalography activity in preterm infants
- Short communication
- The impact of uterine curettage postpartum on maternal sFlt-1 concentration
- Letter to the Editor
- Fetal cerebroplacental ratio and adverse perinatal outcome
- Letter to the Editor – Reply
- Reply to: Fetal cerebroplacental ratio and adverse perinatal outcome
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- The emergence of obstetric medicine
- Mini review
- Folate status and health: challenges and opportunities
- Original articles - Obstetrics
- Increased levels of serum clusterin is associated with intrauterine growth restriction and adverse pregnancy outcomes in preeclampsia
- The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy
- Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia
- Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia
- The prognostic value of first-trimester cystatin C levels for gestational complications
- Experiences of 6 years quality assurance in obstetrics in Nigeria – a critical review of results and obstacles
- Are there anamnestic risk factors for iron deficiency in pregnancy? Results from a feasibility study
- Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
- Pregnancy outcomes among renal transplant recipients and patients with end-stage renal disease on dialysis
- Are pregnant women safer in motor vehicle accidents?
- Amniotic fluid as a source of multipotent cells for clinical use
- Original articles - Newborn
- Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection
- Effects of preeclampsia on the amplitude integrated electroencephalography activity in preterm infants
- Short communication
- The impact of uterine curettage postpartum on maternal sFlt-1 concentration
- Letter to the Editor
- Fetal cerebroplacental ratio and adverse perinatal outcome
- Letter to the Editor – Reply
- Reply to: Fetal cerebroplacental ratio and adverse perinatal outcome
- Congress Calendar
- Congress Calendar