Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
-
Emel Kiyak Caglayan
, Yaprak Engin-Ustun
Abstract
Aim: The aim of this study was to evaluate the relationship between serum sirtuin-1 (SIRT1) level and neutrophil-lymphocyte ratio (NLR) with hyperemesis gravidarum (HG).
Methods: Overall, 90 patients who presented with pregnancy between August 2013 and November 2014 were included in the study. The patients were divided into two groups: patients with HG (n=45) and patients without HG (control group [C]; n=45). The patients with comorbid conditions other than pregnancy (disease or medication) were excluded. In all patients, demographic data including age, body mass index (BMI), gestational week, and smoking status were recorded. Blood samples were drawn for complete blood count and measurements of blood lipid, liver enzymes, serum SIRT1, and insulin levels. NLR was calculated from CBC.
Results: No significant differences were detected in age, BMI, or GA between groups (P>0.05). Serum SIRT1 and NLR were found to be significantly higher in patients with HG compared with those in the control group (P=0.001 and 0.006, respectively).
Conclusion: In HG, both SIRT1 level and NLR increased. In HG, this occurred as a response to metabolic alterations and potential inflammation.
Acknowledgments
The authors have no conflicts of interest relevant to this article. This research has been no financial supported.
References
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©2016 by De Gruyter
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- Congress Calendar
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Articles in the same Issue
- Frontmatter
- Editorial
- The emergence of obstetric medicine
- Mini review
- Folate status and health: challenges and opportunities
- Original articles - Obstetrics
- Increased levels of serum clusterin is associated with intrauterine growth restriction and adverse pregnancy outcomes in preeclampsia
- The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy
- Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia
- Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia
- The prognostic value of first-trimester cystatin C levels for gestational complications
- Experiences of 6 years quality assurance in obstetrics in Nigeria – a critical review of results and obstacles
- Are there anamnestic risk factors for iron deficiency in pregnancy? Results from a feasibility study
- Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
- Pregnancy outcomes among renal transplant recipients and patients with end-stage renal disease on dialysis
- Are pregnant women safer in motor vehicle accidents?
- Amniotic fluid as a source of multipotent cells for clinical use
- Original articles - Newborn
- Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection
- Effects of preeclampsia on the amplitude integrated electroencephalography activity in preterm infants
- Short communication
- The impact of uterine curettage postpartum on maternal sFlt-1 concentration
- Letter to the Editor
- Fetal cerebroplacental ratio and adverse perinatal outcome
- Letter to the Editor – Reply
- Reply to: Fetal cerebroplacental ratio and adverse perinatal outcome
- Congress Calendar
- Congress Calendar