The prognostic value of first-trimester cystatin C levels for gestational complications
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Aslı Yarcı Gursoy
, Yasemin Tasci
Abstract
Aims: This study is designed to evaluate predictive value of first-trimester cystatin C levels for long-term pregnancy complications.
Methods: The cross-sectional study population consisted of patients who admitted to outpatient clinic of a Maternity Hospital between September 2013 and December 2014. Among the 203 participants who accepted to participate in the study, 174 subjects who continued antenatal follow-up in the same clinic were included in the final analyses. Cystatin C, blood urea nitrogen, Creatinine levels and estimated glomerular filtration rates were evaluated in the first-trimester routine antenatal visit. Mode of delivery and gestational complications were noted.
Results: First-trimester cystatin C levels were significantly higher in cases complicated with preterm delivery and premature rupture of membrane (PROM) compared to uncomplicated ones (0.58±0.07 vs. 0.55±0.07, P=0.041, and 0.58±0.07 vs. 0.55±0.07, P=0.036). With a cutoff value of 0.505 mg/L, sensitivity of cystatin C for preterm delivery and PROM was 91.9% and specificity was 27.7% with a negative predictive value of 92.3% and a positive predictive value of 26.6%.
Conclusion: Detection of cystatin C levels in the first trimester of pregnancy for the prediction of preterm/PROM seems as a promising preliminary data. The relatively higher first-trimester cystatin C levels in complicated pregnancies are conspicuous. The results imply that in pregnancy cystatin C might be more than a marker for renal function.
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©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- The emergence of obstetric medicine
- Mini review
- Folate status and health: challenges and opportunities
- Original articles - Obstetrics
- Increased levels of serum clusterin is associated with intrauterine growth restriction and adverse pregnancy outcomes in preeclampsia
- The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy
- Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia
- Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia
- The prognostic value of first-trimester cystatin C levels for gestational complications
- Experiences of 6 years quality assurance in obstetrics in Nigeria – a critical review of results and obstacles
- Are there anamnestic risk factors for iron deficiency in pregnancy? Results from a feasibility study
- Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
- Pregnancy outcomes among renal transplant recipients and patients with end-stage renal disease on dialysis
- Are pregnant women safer in motor vehicle accidents?
- Amniotic fluid as a source of multipotent cells for clinical use
- Original articles - Newborn
- Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection
- Effects of preeclampsia on the amplitude integrated electroencephalography activity in preterm infants
- Short communication
- The impact of uterine curettage postpartum on maternal sFlt-1 concentration
- Letter to the Editor
- Fetal cerebroplacental ratio and adverse perinatal outcome
- Letter to the Editor – Reply
- Reply to: Fetal cerebroplacental ratio and adverse perinatal outcome
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- The emergence of obstetric medicine
- Mini review
- Folate status and health: challenges and opportunities
- Original articles - Obstetrics
- Increased levels of serum clusterin is associated with intrauterine growth restriction and adverse pregnancy outcomes in preeclampsia
- The utility of clinical findings to predict laboratory values in hypertensive disorders of pregnancy
- Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia
- Umbilical cord plasma interferon-induced protein 10 (IP-10) and interferon-induced T-cell alpha chemoattractant (ITAC) levels are lower in women with severe preeclampsia
- The prognostic value of first-trimester cystatin C levels for gestational complications
- Experiences of 6 years quality assurance in obstetrics in Nigeria – a critical review of results and obstacles
- Are there anamnestic risk factors for iron deficiency in pregnancy? Results from a feasibility study
- Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum?
- Pregnancy outcomes among renal transplant recipients and patients with end-stage renal disease on dialysis
- Are pregnant women safer in motor vehicle accidents?
- Amniotic fluid as a source of multipotent cells for clinical use
- Original articles - Newborn
- Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection
- Effects of preeclampsia on the amplitude integrated electroencephalography activity in preterm infants
- Short communication
- The impact of uterine curettage postpartum on maternal sFlt-1 concentration
- Letter to the Editor
- Fetal cerebroplacental ratio and adverse perinatal outcome
- Letter to the Editor – Reply
- Reply to: Fetal cerebroplacental ratio and adverse perinatal outcome
- Congress Calendar
- Congress Calendar