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The prognostic value of first-trimester cystatin C levels for gestational complications

  • Aslı Yarcı Gursoy EMAIL logo , Yasemin Tasci , Hatice Celik , Gamze S. Caglar , Mine Kiseli , Tuba Candar , Selda Demirtas and Salim Erkaya
Published/Copyright: September 10, 2015

Abstract

Aims: This study is designed to evaluate predictive value of first-trimester cystatin C levels for long-term pregnancy complications.

Methods: The cross-sectional study population consisted of patients who admitted to outpatient clinic of a Maternity Hospital between September 2013 and December 2014. Among the 203 participants who accepted to participate in the study, 174 subjects who continued antenatal follow-up in the same clinic were included in the final analyses. Cystatin C, blood urea nitrogen, Creatinine levels and estimated glomerular filtration rates were evaluated in the first-trimester routine antenatal visit. Mode of delivery and gestational complications were noted.

Results: First-trimester cystatin C levels were significantly higher in cases complicated with preterm delivery and premature rupture of membrane (PROM) compared to uncomplicated ones (0.58±0.07 vs. 0.55±0.07, P=0.041, and 0.58±0.07 vs. 0.55±0.07, P=0.036). With a cutoff value of 0.505 mg/L, sensitivity of cystatin C for preterm delivery and PROM was 91.9% and specificity was 27.7% with a negative predictive value of 92.3% and a positive predictive value of 26.6%.

Conclusion: Detection of cystatin C levels in the first trimester of pregnancy for the prediction of preterm/PROM seems as a promising preliminary data. The relatively higher first-trimester cystatin C levels in complicated pregnancies are conspicuous. The results imply that in pregnancy cystatin C might be more than a marker for renal function.

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2015-2-10
Accepted: 2015-8-13
Published Online: 2015-9-10
Published in Print: 2016-4-1

©2016 by De Gruyter

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