Are there gender related differences in neonatal abstinence syndrome following exposure to buprenorphine during pregnancy?
-
Alane B. O’Connor
,
Liam O’Brien
Abstract
Aim: To determine whether infant gender influences the course of neonatal abstinence syndrome (NAS) following exposure to buprenorphine during pregnancy.
Methods: A retrospective cohort study was performed in which maternal and infant data were collected for 46 male and 44 female infants. All infants were born to women enrolled in a buprenorphine treatment program from December 2007 until October 2012. Maternal and infant characteristics and outcomes were compared by infant gender.
Results: Male infants had a significantly higher mean peak NAS score (10.04 vs. 7.98, P=0.028) and were more likely to require pharmacologic treatment for NAS (39.1% vs. 11.4%, P=0.005).
Conclusions: These data indicate that, following exposure to buprenorphine during pregnancy, male infants experience a more severe withdrawal syndrome and are more likely to require pharmacologic treatment for NAS.
References
[1] Bernardes J, Gonçalves H, Ayres-de-Campos D, Rocha AP. Sex differences in linear and complex fetal heart rate dynamics of normal and acidemic fetuses in the minutes preceding delivery. J Perinat Med. 2009;37:168–76.10.1515/JPM.2009.024Suche in Google Scholar PubMed
[2] Dysart K, Hsieh H, Kaltenbach K, Greenspan JS. Sequela of preterm versus term infants born to mothers on a methadone maintenance program: differential course of neonatal abstinence syndrome. J Perinat Med. 2007;35:344–6.10.1515/JPM.2007.063Suche in Google Scholar PubMed
[3] Holbrook A, Kaltenbach K. Gender and NAS: does sex matter? Drug Alcohol Depend. 2010;112:156–9.10.1016/j.drugalcdep.2010.05.015Suche in Google Scholar PubMed
[4] Hudak ML, Tan RC, Committee on Drugs, Committee on Fetus and Newborn. Neonatal drug withdrawal. Pediatrics. 2012;129:e540–60.10.1542/peds.2011-3212Suche in Google Scholar PubMed
[5] Jansson LM, DiPietro JA, Elko A, Velez M. Infant autonomic functioning and neonatal abstinence syndrome. Drug Alcohol Depend. 2010;109:198–204.10.1016/j.drugalcdep.2010.01.004Suche in Google Scholar PubMed PubMed Central
[6] Jansson LM, DiPietro JA, Elko A, Velez M. Maternal vagal tone change in response to methadone is associated with neonatal abstinence syndrome severity in exposed neonates. J Matern Fetal Neonat Med. 2007;20:677–85.10.1080/14767050701490327Suche in Google Scholar PubMed
[7] Jones HE, Kaltenbach K, Heil SH, Stine SM, Coyle MG, Arria AM, et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med. 2010;363:2320–31.10.1056/NEJMoa1005359Suche in Google Scholar PubMed PubMed Central
[8] Lejeune C, Simmat-Durrand L, Gourarier L, Aubisson S, Groupe d’Etudes Grossesse et Addictions (GEGA). Prospective multicenter observational study of 260 infants born to 259 opiate-dependent mothers on methadone or high-dose buprenorphine substitution. Drug Alcohol Depend. 2006;82:250–7.10.1016/j.drugalcdep.2005.10.001Suche in Google Scholar PubMed
[9] Unger A, Jagsch R, Bawert A, Winklbaur B, Rohrmeister K, Martin PR, et al. Are male neonates more vulnerable to neonatal abstinence syndrome than female neonates? Gend Med. 2011;8:355–64.10.1016/j.genm.2011.10.001Suche in Google Scholar PubMed PubMed Central
[10] Weinberg M, Tronick EZ, Cohn JF, Olson KL. Gender differences in emotional expressivity and self-regulation during early infancy. Dev Psychol. 1999;35:175–88.10.1037/0012-1649.35.1.175Suche in Google Scholar
The authors stated that there are no conflicts of interest regarding the publication of this article.
©2013 by Walter de Gruyter Berlin Boston
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