A polymorphism in an autophagy-related gene, ATG16L1, influences time to delivery in women with an unfavorable cervix who require labor induction
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Georgios Doulaveris
Abstract
Autophagy is an intracellular process that maintains homeostasis by the removal of damaged organelles and proteins. A single nucleotide polymorphism (SNP) in the autophagy-related 16-like 1 (ATG16L1) gene results in decreased autophagy. We evaluated whether the ATG16L1 polymorphism influenced the time to delivery during labor induction in pregnant women with an unfavorable cervix. DNA from 69 women with an unfavorable cervix who required labor induction due to post-term (>294 days) (n=26), oligohydramnios (n=17), hypertension or pre-eclampsia (n=10), abnormal fetal heart rate (n=8), diabetes (n=3) or other reasons (n=5) was tested by gene amplification and endonuclease digestion for a SNP in ATG16L1 (rs2241880). The mean hours (SD) from induction to delivery was 20.8 (9.7) for women who were A,A homozygotes, 19.2 (8.8) for A,G heterozygotes and 14.3 (6.6) for homozygote carriers of the G,G variant (P=0.03 A,A vs. G,G, P=0.04 A,A/A,G vs. G,G). The G,G prevalence was 24.4% and 4.2% for those who delivered in ≤24 and >24 h, respectively (P=0.04). There was no difference in genotype distribution by indication for induction. A decreased genetic capacity for autophagy may be beneficial in women with an unfavorable cervix whose labor has to be induced.
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The authors stated that there are no conflicts of interest regarding the publication of this article.
©2013 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Review article
- Anxious and depressive components of Edinburgh Postnatal Depression Scale in maternal postpartum psychological problems1)
- Original Articles – Obstetrics
- Isolated low-normal amniotic fluid volume in the early third trimester: association with adverse perinatal outcomesa
- Trends in twin pregnancies and mode of delivery during the last 30 years: inconsistency between guidelines and clinical practice
- Prenatal care in adult women exposed to childhood sexual abuse
- Maternal and fetal adropin levels in gestational diabetes mellitus
- Ethnic disparities in perinatal mortality at 40 and 41 weeks of gestation
- Polymorphisms in the activin A receptor type 2A gene affect the onset time and severity of preeclampsia in the Turkish population
- Outcome of isolated fetal renal pyelectasis diagnosed during midtrimester screening ultrasound and cut-off value to predict a persistent or progressive pyelectasis in utero
- A polymorphism in an autophagy-related gene, ATG16L1, influences time to delivery in women with an unfavorable cervix who require labor induction
- Management of gestational hypertension – the impact of HYPITATa
- Reliability of quantitative elastography of the uterine cervix in at-term pregnancies
- Congenital anomalies, prematurity, and low birth weight rates in relation to nuclear power plant proximity1)
- Original Articles – Fetus
- Fetal magnetic resonance imaging of lymphangiomas
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