Startseite MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among north Indian women
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MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among north Indian women

  • Manju Puri , Lovejeet Kaur , Gagandeep Kaur Walia , Rupak Mukhopadhhyay , Mohinder Pal Sachdeva , Shubha Sagar Trivedi , Pradeep Kumar Ghosh und Kallur Nava Saraswathy EMAIL logo
Veröffentlicht/Copyright: 16. April 2013

Abstract

Aim: The present study attempts to understand the role of methylenetetrahydrofolate reductase C677T (MTHFR C677T) in recurrent pregnancy losses in North Indian women because of hyperhomocysteinemia in light of serum folate and vitamin B12.

Methods: One hundred and seven women with three or more consecutive unexplained recurrent pregnancy losses and 343 women with two or more successful and uncomplicated pregnancies were recruited. Plasma homocysteine, serum folate and vitamin B12 were analyzed using chemiluminescence. MTHFR C677T detection was completed in all subjects.

Results:MTHFR genotypic distribution among cases and controls showed no significant difference (P=0.409). However, MTHFR C677T polymorphism was found to be significantly associated with increased homocysteine in the case group (P=0.031). Hyperhomocysteinemia and vitamin B12 deficiency were found to be significant risk factors for recurrent pregnancy loss (RPL) (OR=7.02 and 16.39, respectively). Folate deficiency was more common in controls (63.47%) as compared to the case group (2.56%).

Conclusion: Low vitamin B12 increases homocysteine, specifically among T allele carrying case mothers, suggesting T allele is detrimental with B12 deficiency. The study emphasizes the importance of vitamin B12 in the prevention of RPL in North Indian women.


Corresponding author: Dr. Kallur Nava Saraswathy, Department of Anthropology, University of Delhi, Delhi-7, India, Tel.: +91-011-64586216

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2012-10-26
Accepted: 2013-3-18
Published Online: 2013-04-16
Published in Print: 2013-09-01

©2013 by Walter de Gruyter Berlin Boston

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