Placental transfer of clarithromycin in human pregnancies with preterm premature rupture of membranes
-
Hyun Soo Park
Abstract
Aim: The aim of this study was to evaluate the transplacental transfer of clarithromycin, which was used in the treatment of preterm premature rupture of membranes (PPROM) in human pregnancies, by comparing umbilical cord and maternal serum clarithromycin concentrations.
Methods: Singleton pregnant women with PPROM (<34 weeks) were prospectively enrolled between April 2009 and January 2011. The diagnosis of PPROM was made with vaginal pooling, leakage, nitrazine, and Amnisure tests. The women were managed expectantly with bed rest, corticosteroids, and a triple antibiotic combination including ceftriaxone, clindamycin, and clarithromycin. Amniocentesis was offered, and culture for aerobe/anaerobe and mycoplasma was performed. After delivery, blood was drawn from the mother’s antecubital and umbilical cord veins. Clarithromycin concentrations were measured using liquid chromatography-tandem mass spectrometry. The percentage and correlation between cord and maternal serum clarithromycin concentrations were calculated. Logistic regression analysis was performed to investigate the factors related to the cord and maternal serum clarithromycin concentration percentage.
Results: A total of 34 cord-maternal serum pairs were included in the final analysis. The mean cord-maternal serum clarithromycin concentration percentage was 7.93±0.9%. There was a good correlation between cord serum and maternal serum clarithromycin concentration (r=0.795, P<0.001). The cord-maternal serum clarithromycin concentration percentage significantly increased according to advancing gestation (P<0.001).
Conclusions: Our data showed that the mean placental transfer of clarithromycin is approximately 8% and dependent on gestational age.
©2012 by Walter de Gruyter Berlin Boston
Artikel in diesem Heft
- Masthead
- Masthead
- Original Articles – Obstetrics
- Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial
- Association of high-sensitivity C-reactive protein serum levels in early pregnancy with the severity of preeclampsia and fetal birth weight
- High-fidelity simulation increases obstetric self-assurance and skills in undergraduate medical students
- Resident consultant presence in labour ward after midnight – a retrospective cohort study of 5318 deliveries
- Carboxyhemoglobin levels in umbilical cord blood of women with pre-eclampsia and intrauterine growth restriction
- Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis
- What about ST waveform analysis signal quality in the second stage of labor? A case-control study
- A curriculum to teach and evaluate resident skills in the management of postpartum hemorrhage
- Placental transfer of clarithromycin in human pregnancies with preterm premature rupture of membranes
- Stepwise sequential screening for Down’s syndrome (combined test associated with modified genetic sonography) in pregnant women with low risk for chromosomal disorders
- Original Articles – Fetus
- Mode of anaesthesia on fetal acid-base status at caesarean section
- Development of integrative autonomic nervous system function: an investigation based on time correlation in fetal heart rate patterns
- Original Articles – Newborn
- Guttus, tiralatte and téterelle: a history of breast pumps
- Does docosahexaenoic acid (DHA) status in pregnancy have any impact on postnatal growth? Six-year follow-up of a prospective randomized double-blind monocenter study on low-dose DHA supplements
- The evolution of risk factors for respiratory syncytial virus-related hospitalisation in infants born at 32–35 weeks’ gestational age: time-based analysis using data from the FLIP-2 study
- Short Communications
- Low placental weight and risk for fetal distress at birth
- Electrical pacemaker as a safe and feasible method for decreasing the uterine contractions of human preterm labor
- Congress Calendar
- Congress Calendar
- WAPM Newsletter
- WAPM Newsletter
Artikel in diesem Heft
- Masthead
- Masthead
- Original Articles – Obstetrics
- Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial
- Association of high-sensitivity C-reactive protein serum levels in early pregnancy with the severity of preeclampsia and fetal birth weight
- High-fidelity simulation increases obstetric self-assurance and skills in undergraduate medical students
- Resident consultant presence in labour ward after midnight – a retrospective cohort study of 5318 deliveries
- Carboxyhemoglobin levels in umbilical cord blood of women with pre-eclampsia and intrauterine growth restriction
- Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis
- What about ST waveform analysis signal quality in the second stage of labor? A case-control study
- A curriculum to teach and evaluate resident skills in the management of postpartum hemorrhage
- Placental transfer of clarithromycin in human pregnancies with preterm premature rupture of membranes
- Stepwise sequential screening for Down’s syndrome (combined test associated with modified genetic sonography) in pregnant women with low risk for chromosomal disorders
- Original Articles – Fetus
- Mode of anaesthesia on fetal acid-base status at caesarean section
- Development of integrative autonomic nervous system function: an investigation based on time correlation in fetal heart rate patterns
- Original Articles – Newborn
- Guttus, tiralatte and téterelle: a history of breast pumps
- Does docosahexaenoic acid (DHA) status in pregnancy have any impact on postnatal growth? Six-year follow-up of a prospective randomized double-blind monocenter study on low-dose DHA supplements
- The evolution of risk factors for respiratory syncytial virus-related hospitalisation in infants born at 32–35 weeks’ gestational age: time-based analysis using data from the FLIP-2 study
- Short Communications
- Low placental weight and risk for fetal distress at birth
- Electrical pacemaker as a safe and feasible method for decreasing the uterine contractions of human preterm labor
- Congress Calendar
- Congress Calendar
- WAPM Newsletter
- WAPM Newsletter
