The evolution of risk factors for respiratory syncytial virus-related hospitalisation in infants born at 32–35 weeks’ gestational age: time-based analysis using data from the FLIP-2 study
-
Xavier Carbonell
,
Katherine L. Gooch
Abstract
Aim: The aim of this study was to examine whether the risk for respiratory syncytial virus (RSV)-related hospitalisation changes through the first year of life in infants of 32–35 weeks’ gestational age (wGA).
Methods: Risk factors from the FLIP-2 study (190 cases/4566 age-matched controls) were included in a Cox regression analysis wherein time slices were taken at 1-month intervals from birth.
Results: Half of all RSV hospitalisations occurred in the first 68 days after birth, with 56% occurring within 90 days. The time taken for 50% of hospitalisations to occur was 148 days for those born outside the RSV season and 58 days for those born within the season. By 90 days old, 84% of infants born in the season and 20% of those born outside the season were hospitalised. In both groups, hospitalisations occurred ≥5 months after birth. Male sex, smoking whilst pregnant, month of birth, duration of breastfeeding, number of siblings at school, and number of smokers in household all contributed to the risk of RSV hospitalisation beyond the age of 90 days.
Conclusions: The risk of RSV hospitalisation appears to persist to at least 5–6 months old in 32–35 wGA infants, which has implications for the optimal management of disease prevention.
©2012 by Walter de Gruyter Berlin Boston
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- Masthead
- Masthead
- Original Articles – Obstetrics
- Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial
- Association of high-sensitivity C-reactive protein serum levels in early pregnancy with the severity of preeclampsia and fetal birth weight
- High-fidelity simulation increases obstetric self-assurance and skills in undergraduate medical students
- Resident consultant presence in labour ward after midnight – a retrospective cohort study of 5318 deliveries
- Carboxyhemoglobin levels in umbilical cord blood of women with pre-eclampsia and intrauterine growth restriction
- Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis
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- Original Articles – Fetus
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- Congress Calendar
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