Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial
-
Stephen Wood
,
Sue Ross
Abstract
Aim: We sought to assess the effect of progesterone in increasing or decreasing duration of pregnancy for mothers with twins and triplets.
Methods: Women with multiple pregnancy were randomized at 16+0 to 20+6 weeks’ gestation to receive daily doses of either 90 mg progesterone vaginal gel or placebo until 35+6 weeks or delivery. Primary outcome was gestational age (GA) at delivery. Secondary outcomes included preterm birth, infant morbidity and mortality, and adverse events up to 28 days after delivery. A sample size of 40 per group was required to detect a 2-week difference in GA at delivery.
Results: Eighty-four women were randomized (42 to progesterone, 42 to placebo). Median GA at delivery was 36+3 and 36+2, respectively (difference, 1 day; 95% confidence interval, 4 to –1 days, P=0.585). There were no clinically or statistically significant differences between groups for risk of delivery before 35 or 37 weeks’ GA, rates of infant morbidity and mortality, treatment compliance, or adverse events.
Conclusions: Daily treatment with progesterone gel did not prolong multiple pregnancy compared with placebo. Effective prevention strategies are needed to reduce preterm deliveries among women with multiple gestations.
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Original Articles – Obstetrics
- Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial
- Association of high-sensitivity C-reactive protein serum levels in early pregnancy with the severity of preeclampsia and fetal birth weight
- High-fidelity simulation increases obstetric self-assurance and skills in undergraduate medical students
- Resident consultant presence in labour ward after midnight – a retrospective cohort study of 5318 deliveries
- Carboxyhemoglobin levels in umbilical cord blood of women with pre-eclampsia and intrauterine growth restriction
- Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis
- What about ST waveform analysis signal quality in the second stage of labor? A case-control study
- A curriculum to teach and evaluate resident skills in the management of postpartum hemorrhage
- Placental transfer of clarithromycin in human pregnancies with preterm premature rupture of membranes
- Stepwise sequential screening for Down’s syndrome (combined test associated with modified genetic sonography) in pregnant women with low risk for chromosomal disorders
- Original Articles – Fetus
- Mode of anaesthesia on fetal acid-base status at caesarean section
- Development of integrative autonomic nervous system function: an investigation based on time correlation in fetal heart rate patterns
- Original Articles – Newborn
- Guttus, tiralatte and téterelle: a history of breast pumps
- Does docosahexaenoic acid (DHA) status in pregnancy have any impact on postnatal growth? Six-year follow-up of a prospective randomized double-blind monocenter study on low-dose DHA supplements
- The evolution of risk factors for respiratory syncytial virus-related hospitalisation in infants born at 32–35 weeks’ gestational age: time-based analysis using data from the FLIP-2 study
- Short Communications
- Low placental weight and risk for fetal distress at birth
- Electrical pacemaker as a safe and feasible method for decreasing the uterine contractions of human preterm labor
- Congress Calendar
- Congress Calendar
- WAPM Newsletter
- WAPM Newsletter
Articles in the same Issue
- Masthead
- Masthead
- Original Articles – Obstetrics
- Vaginal progesterone to prevent preterm birth in multiple pregnancy: a randomized controlled trial
- Association of high-sensitivity C-reactive protein serum levels in early pregnancy with the severity of preeclampsia and fetal birth weight
- High-fidelity simulation increases obstetric self-assurance and skills in undergraduate medical students
- Resident consultant presence in labour ward after midnight – a retrospective cohort study of 5318 deliveries
- Carboxyhemoglobin levels in umbilical cord blood of women with pre-eclampsia and intrauterine growth restriction
- Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis
- What about ST waveform analysis signal quality in the second stage of labor? A case-control study
- A curriculum to teach and evaluate resident skills in the management of postpartum hemorrhage
- Placental transfer of clarithromycin in human pregnancies with preterm premature rupture of membranes
- Stepwise sequential screening for Down’s syndrome (combined test associated with modified genetic sonography) in pregnant women with low risk for chromosomal disorders
- Original Articles – Fetus
- Mode of anaesthesia on fetal acid-base status at caesarean section
- Development of integrative autonomic nervous system function: an investigation based on time correlation in fetal heart rate patterns
- Original Articles – Newborn
- Guttus, tiralatte and téterelle: a history of breast pumps
- Does docosahexaenoic acid (DHA) status in pregnancy have any impact on postnatal growth? Six-year follow-up of a prospective randomized double-blind monocenter study on low-dose DHA supplements
- The evolution of risk factors for respiratory syncytial virus-related hospitalisation in infants born at 32–35 weeks’ gestational age: time-based analysis using data from the FLIP-2 study
- Short Communications
- Low placental weight and risk for fetal distress at birth
- Electrical pacemaker as a safe and feasible method for decreasing the uterine contractions of human preterm labor
- Congress Calendar
- Congress Calendar
- WAPM Newsletter
- WAPM Newsletter
