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The pros and cons of sex steroid priming in growth hormone stimulation testing
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Lawrence A. Wetterau
Veröffentlicht/Copyright:
12. Oktober 2012
Abstract
Diagnosing growth hormone deficiency (GHD) remains a challenge, and the role of sex steroid priming in the diagnosis of GHD continues to be debated. This review examines existing data on sex steroid priming during GHD diagnosis. Primary literature was reviewed in the area of sex steroid priming and growth hormone stimulation tests. Studies supporting sex steroid priming suggest improved diagnostic efficiency with reduced false diagnosis of GHD in peripubertal children. Those that do not support sex steroid priming note the potential for underdiagnosis of GHD and the lack of standardization in sex steroid priming procedures. To date, there is no consensus on the use of sex steroid priming prior to performing growth hormone stimulation tests in the evaluation of GHD. A more targeted approach to using sex steroid priming may be reasonable; however, the decision of whether or not to use sex steroid priming should remain with the individual clinician.
Received: 2011-6-27
Accepted: 2011-11-15
Published Online: 2012-10-12
Published in Print: 2012-12-01
©2012 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Review article
- The pros and cons of sex steroid priming in growth hormone stimulation testing
- Images in pediatric endocrinology
- Tuber sinerium hamartoma causing precocious puberty in a child
- Original articles
- Clinical features suggestive of non-classical 21-hydroxylase deficiency in children presenting with precocious pubarche
- Disorders of sex development among Sudanese children: 5-year experience of a pediatric endocrinology clinic
- Anti-Müllerian hormone levels in serum 1 year after unilateral orchiopexy
- Clinical and genetic analysis of three Chinese patients with steroid 5α-reductase type 2 deficiency
- Apparent mineralocorticoid excess syndrome: report of one family with three affected children
- A decrease in fasting FGF19 levels is associated with the development of non-alcoholic fatty liver disease in obese adolescents
- Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children
- Nutritional and metabolic findings in patients with Prader-Willi syndrome diagnosed in early infancy
- Increased endothelial microparticles in obese and overweight children
- The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism
- Hyperprolactinemia in children: clinical features and long-term results
- Oxidant/antioxidant system markers and trace element levels in children with nutritional rickets
- Single-nucleotide polymorphism of the osteoprotegerin gene and its association with bone mineral density in Chinese postmenopausal women
- A case of complete androgen insensitivity syndrome with a novel androgen receptor mutation
- Patient reports
- Mild and severe congenital primary hypothyroidism in two patients by thyrotropin receptor (TSHR) gene mutation
- An unusual cause of delayed puberty: Berardinelli-Seip syndrome
- Primary hypogonadism in a case with XLAG syndrome
- Precocious puberty produced by an osteolipoma of the tuber cinereum
- A case of Mayer-Rokitansky-Küster-Hauser syndrome presenting as Graves disease
- Priapism in teenage boys following depot testosterone
- Spontaneous resolution of pituitary apoplexy in a giant boy under 10 years old
- Congenital craniopharyngioma: a case report and literature review
- Growth and hormonal profile from birth to adolescence of a girl with aromatase deficiency
- Chylomicron retention disease: report of two cases from a Greek Island
- Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease
- Hepatic subcapsular steatosis: a rare complication of high dose insulin therapy
- Infantile malignant osteopetrosis: a rare cause of neonatal hypocalcemia
- Unusual presentations of a girl with Down syndrome: Van Wyk-Grumbach syndrome
- Short communications
- Cortisol response to the Trier Social Stress Test among Chinese adolescents
- Inhaled fluticasone propionate does not influence salivary cortisol when measured with tandem mass spectrometry
Schlagwörter für diesen Artikel
growth hormone deficiency;
growth hormone stimulation tests;
sex steroid priming
Artikel in diesem Heft
- Masthead
- Masthead
- Review article
- The pros and cons of sex steroid priming in growth hormone stimulation testing
- Images in pediatric endocrinology
- Tuber sinerium hamartoma causing precocious puberty in a child
- Original articles
- Clinical features suggestive of non-classical 21-hydroxylase deficiency in children presenting with precocious pubarche
- Disorders of sex development among Sudanese children: 5-year experience of a pediatric endocrinology clinic
- Anti-Müllerian hormone levels in serum 1 year after unilateral orchiopexy
- Clinical and genetic analysis of three Chinese patients with steroid 5α-reductase type 2 deficiency
- Apparent mineralocorticoid excess syndrome: report of one family with three affected children
- A decrease in fasting FGF19 levels is associated with the development of non-alcoholic fatty liver disease in obese adolescents
- Acanthosis nigricans predicts the clustering of metabolic syndrome components in Hispanic elementary school-aged children
- Nutritional and metabolic findings in patients with Prader-Willi syndrome diagnosed in early infancy
- Increased endothelial microparticles in obese and overweight children
- The treatment effect of diazoxide on 44 patients with congenital hyperinsulinism
- Hyperprolactinemia in children: clinical features and long-term results
- Oxidant/antioxidant system markers and trace element levels in children with nutritional rickets
- Single-nucleotide polymorphism of the osteoprotegerin gene and its association with bone mineral density in Chinese postmenopausal women
- A case of complete androgen insensitivity syndrome with a novel androgen receptor mutation
- Patient reports
- Mild and severe congenital primary hypothyroidism in two patients by thyrotropin receptor (TSHR) gene mutation
- An unusual cause of delayed puberty: Berardinelli-Seip syndrome
- Primary hypogonadism in a case with XLAG syndrome
- Precocious puberty produced by an osteolipoma of the tuber cinereum
- A case of Mayer-Rokitansky-Küster-Hauser syndrome presenting as Graves disease
- Priapism in teenage boys following depot testosterone
- Spontaneous resolution of pituitary apoplexy in a giant boy under 10 years old
- Congenital craniopharyngioma: a case report and literature review
- Growth and hormonal profile from birth to adolescence of a girl with aromatase deficiency
- Chylomicron retention disease: report of two cases from a Greek Island
- Cerebellar metastatic papillary thyroid carcinoma in a pediatric patient with complex congenital heart disease
- Hepatic subcapsular steatosis: a rare complication of high dose insulin therapy
- Infantile malignant osteopetrosis: a rare cause of neonatal hypocalcemia
- Unusual presentations of a girl with Down syndrome: Van Wyk-Grumbach syndrome
- Short communications
- Cortisol response to the Trier Social Stress Test among Chinese adolescents
- Inhaled fluticasone propionate does not influence salivary cortisol when measured with tandem mass spectrometry
