Startseite Initial neutrophil/lymphocyte and lymphocyte/monocyte ratios can predict future insulin need in newly diagnosed type 1 diabetes mellitus
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Initial neutrophil/lymphocyte and lymphocyte/monocyte ratios can predict future insulin need in newly diagnosed type 1 diabetes mellitus

  • İbrahim Mert Erbaş ORCID logo , Aygün Hajikhanova , Özge Besci ORCID logo , Kübra Yüksek Acinikli , Korcan Demir ORCID logo , Ece Böber ORCID logo und Ayhan Abacı ORCID logo EMAIL logo
Veröffentlicht/Copyright: 18. März 2022
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 35 Heft 5

Abstract

Objectives

The exact mechanism of partial clinical remission in type 1 diabetes mellitus (T1DM) has not been elucidated yet. The severity of the inflammation at the time of diagnosis may affect the occurrence or duration of this phase. We aimed to investigate the relationship between hematological inflammatory parameters at the time of diagnosis in T1DM and (i) daily insulin requirement during the follow-up and (ii) the presence of partial clinical remission period, which was determined according to insulin dose-adjusted HbA1c levels.

Methods

A single-center retrospective study was conducted, including children who were diagnosed with T1DM, were positive for at least one autoantibody, and were followed up for one year in our clinic between 2010 and 2020.

Results

Sixty-eight patients (55.9% female, 64.7% prepubertal) were included in the study, whose mean age was 8.4 ± 4.2 years. A total of 38 patients (55.9%) had partial clinical remission. None of the initial hematological indices were associated with the occurrence of partial remission. Initial neutrophil/lymphocyte ratio (NLR) and derived-NLR (d-NLR) levels were significantly lower (p=0.011 and 0.033, respectively) and lymphocyte/monocyte ratio (LMR) levels were significantly higher (p=0.005) in patients who showed an insulin requirement of <0.5 IU/kg/day at the 3rd month after diagnosis.

Conclusions

Initial hematological parameters were not found as a predictor of partial clinical remission period in T1DM in children. However, a lower NLR and d-NLR, or a higher LMR at the time of diagnosis can be used as an indicator of a low daily insulin need at the 3rd month of T1DM.

Keywords: honeymoon phase; inflammatory markers; insulin-dependent diabetes mellitus; pediatrics
Corresponding author: Prof. Dr. Ayhan Abacı, Division of Pediatric Endocrinology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey, Phone: +902324126076, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: This study was approved by the local Ethics Committee (Approval number: 2021/14-01) and performed in line with the principles of the Declaration of Helsinki.

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Received: 2021-08-28
Accepted: 2022-02-19
Published Online: 2022-03-18
Published in Print: 2022-05-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Impact of Obesity on Bone Metabolism in Children
  4. Mini Review
  5. Late sequelae of drug reaction with eosinophilia and systemic symptoms (DRESS) cause thyroid dysfunction and thyroiditis: review of literature
  6. Original Articles
  7. Moderating effect of bone maturation on the relationship between body fat and insulin resistance
  8. Prevalence of nephropathy in Indian children and youth with type 1 diabetes mellitus
  9. Initial neutrophil/lymphocyte and lymphocyte/monocyte ratios can predict future insulin need in newly diagnosed type 1 diabetes mellitus
  10. Subcutaneous adipose tissue is a positive predictor for bone mineral density in prepubertal children with Prader–Willi syndrome independent of lean mass
  11. The attitudes, experiences, and self-competencies of pediatric endocrinology fellows and attending physicians regarding diabetes technology: the Turkey experience
  12. Adiposity measures in screening for metabolic syndrome among Chinese children and adolescents
  13. Increased anxiety symptoms in pediatric type 1 diabetes during the acute phase of COVID-19 lockdown
  14. Pediatric adrenal insufficiency: thirty years experience at a Portuguese hospital
  15. Spectrum of PAH gene mutations and genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Turkey
  16. Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term
  17. Familial early-onset obesity in Turkish children: variants and polymorphisms in the melanocortin-4 receptor (MC4R) gene
  18. An update of the mutation spectrum of phenylalanine hydroxylase (PAH) gene in the population of Turkey
  19. Primary hypertriglyceridemia induced pancreatitis in a cohort of Pakistani children
  20. Investigation of the relationship between serum sclerostin and dickkopf-1 protein levels with bone turnover in children and adolescents with type-1 diabetes mellitus
  21. Case Reports
  22. Diagnostic value of plasma lysosphingolipids levels in a Niemann–Pick disease type C patient with transient neonatal cholestasis
  23. A 7-year-old boy with central diabetes insipidus presenting with thickened pituitary stalk and anti-rabphilin-3A antibody positivity
  24. Homozygous missense variant of PTH (c.166C>T, p.(Arg56Cys)) as the cause of familial isolated hypoparathyroidism in a three-year-old child
  25. Long-term follow-up of transient neonatal diabetes mellitus due to a novel homozygous c.7734C>T (p.R228C) mutation in ZFP57 gene: relapse at prepubertal age
https://doi.org/10.1515/jpem-2021-0564
Schlagwörter für diesen Artikel
honeymoon phase; inflammatory markers; insulin-dependent diabetes mellitus; pediatrics

Artikel in diesem Heft

  1. Frontmatter
  2. Review Article
  3. Impact of Obesity on Bone Metabolism in Children
  4. Mini Review
  5. Late sequelae of drug reaction with eosinophilia and systemic symptoms (DRESS) cause thyroid dysfunction and thyroiditis: review of literature
  6. Original Articles
  7. Moderating effect of bone maturation on the relationship between body fat and insulin resistance
  8. Prevalence of nephropathy in Indian children and youth with type 1 diabetes mellitus
  9. Initial neutrophil/lymphocyte and lymphocyte/monocyte ratios can predict future insulin need in newly diagnosed type 1 diabetes mellitus
  10. Subcutaneous adipose tissue is a positive predictor for bone mineral density in prepubertal children with Prader–Willi syndrome independent of lean mass
  11. The attitudes, experiences, and self-competencies of pediatric endocrinology fellows and attending physicians regarding diabetes technology: the Turkey experience
  12. Adiposity measures in screening for metabolic syndrome among Chinese children and adolescents
  13. Increased anxiety symptoms in pediatric type 1 diabetes during the acute phase of COVID-19 lockdown
  14. Pediatric adrenal insufficiency: thirty years experience at a Portuguese hospital
  15. Spectrum of PAH gene mutations and genotype–phenotype correlation in patients with phenylalanine hydroxylase deficiency from Turkey
  16. Serum spexin levels are not associated with size at birth but are associated with metabolic syndrome components in prepubertal children born at term
  17. Familial early-onset obesity in Turkish children: variants and polymorphisms in the melanocortin-4 receptor (MC4R) gene
  18. An update of the mutation spectrum of phenylalanine hydroxylase (PAH) gene in the population of Turkey
  19. Primary hypertriglyceridemia induced pancreatitis in a cohort of Pakistani children
  20. Investigation of the relationship between serum sclerostin and dickkopf-1 protein levels with bone turnover in children and adolescents with type-1 diabetes mellitus
  21. Case Reports
  22. Diagnostic value of plasma lysosphingolipids levels in a Niemann–Pick disease type C patient with transient neonatal cholestasis
  23. A 7-year-old boy with central diabetes insipidus presenting with thickened pituitary stalk and anti-rabphilin-3A antibody positivity
  24. Homozygous missense variant of PTH (c.166C>T, p.(Arg56Cys)) as the cause of familial isolated hypoparathyroidism in a three-year-old child
  25. Long-term follow-up of transient neonatal diabetes mellitus due to a novel homozygous c.7734C>T (p.R228C) mutation in ZFP57 gene: relapse at prepubertal age
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